Page last updated: 2024-09-02

sr 95531 and propofol

sr 95531 has been researched along with propofol in 11 studies

Compound Research Comparison

Studies
(sr 95531)
Trials
(sr 95531)
Recent Studies (post-2010)
(sr 95531)
Studies
(propofol)
Trials
(propofol)
Recent Studies (post-2010) (propofol)
610020916,8275,1886,805

Protein Interaction Comparison

ProteinTaxonomysr 95531 (IC50)propofol (IC50)
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)8.1667
Aldo-keto reductase family 1 member B1Rattus norvegicus (Norway rat)9.393
Polyunsaturated fatty acid lipoxygenase ALOX15Oryctolagus cuniculus (rabbit)7.596
Gamma-aminobutyric acid receptor subunit alpha-1Homo sapiens (human)8
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit gamma-2Homo sapiens (human)8
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)8.1667
Prostaglandin G/H synthase 1Homo sapiens (human)3.832
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)8.1667
Sodium-dependent noradrenaline transporter Homo sapiens (human)9.393
Sodium- and chloride-dependent GABA transporter 1Rattus norvegicus (Norway rat)8.3
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit beta-3Homo sapiens (human)8
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)8.1667
Sodium- and chloride-dependent GABA transporter 2Rattus norvegicus (Norway rat)8.3
Sodium- and chloride-dependent GABA transporter 3Rattus norvegicus (Norway rat)8.3
5-hydroxytryptamine receptor 2BHomo sapiens (human)5.499
Sodium- and chloride-dependent betaine transporterRattus norvegicus (Norway rat)8.3
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)8.1667
GABA theta subunitRattus norvegicus (Norway rat)8.1667
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)8.1667

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's7 (63.64)29.6817
2010's3 (27.27)24.3611
2020's1 (9.09)2.80

Authors

AuthorsStudies
Bai, D; Jackson, MF; MacDonald, JF; Orser, BA; Pennefather, P; Zhu, G1
Abaigar, W; Bovill, JG; Laster, MJ; Sonner, JM; Stabernack, C; Xing, Y; Zhang, Y1
Andreeva, N; Garret, M; Haas, HL; Scherer, A; Sergeeva, OA1
daGraca, RL; Delphin, E; Li, KY; Nguyen, HT; Xiong, M; Ye, JH1
Emala, CW; Gallos, G; Gleason, NR; Mizuta, K; Virag, L; Whittington, RA; Zhang, Y1
Basson, MD; Kouatli, Y; Marsh, HM; Shiratsuchi, H; Yu, GX1
Andresen, MC; Jin, YH; Mendelowitz, D; Zhang, Z1
Bjornstrom, K; Eintrei, C; Sundqvist, T; Turina, D1
Aiba, I; Shuttleworth, CW1
Chu, CP; He, YY; Jin, R; Jin, WZ; Liu, H; Qiu, DL1
Jiao, Y; Li, K; Li, Z; Xing, Y1

Other Studies

11 other study(ies) available for sr 95531 and propofol

ArticleYear
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.
    Molecular pharmacology, 2001, Volume: 59, Issue:4

    Topics: Animals; Bicuculline; Cells, Cultured; Dose-Response Relationship, Drug; Drug Synergism; Excitatory Postsynaptic Potentials; GABA Antagonists; GABA-A Receptor Antagonists; Hippocampus; Hypnotics and Sedatives; In Vitro Techniques; Mice; Midazolam; Models, Neurological; Neural Inhibition; Neurons; Patch-Clamp Techniques; Picrotoxin; Propofol; Pyridazines; Receptors, GABA-A

2001
GABA(A) receptor blockade antagonizes the immobilizing action of propofol but not ketamine or isoflurane in a dose-related manner.
    Anesthesia and analgesia, 2003, Volume: 96, Issue:3

    Topics: Anesthetics, Dissociative; Anesthetics, Inhalation; Anesthetics, Intravenous; Animals; Bicuculline; Dose-Response Relationship, Drug; Excitatory Amino Acid Antagonists; GABA Antagonists; GABA-A Receptor Antagonists; Glycine Agents; Infusions, Intravenous; Injections, Intraperitoneal; Isoflurane; Ketamine; Male; Picrotoxin; Propofol; Pulmonary Alveoli; Pyridazines; Rats; Rats, Sprague-Dawley; Strychnine

2003
Pharmacological properties of GABAA receptors in rat hypothalamic neurons expressing the epsilon-subunit.
    The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005, Jan-05, Volume: 25, Issue:1

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Diazepam; Electrophysiology; Fluorescent Antibody Technique; gamma-Aminobutyric Acid; Hypothalamic Area, Lateral; Hypothalamus; Intracellular Signaling Peptides and Proteins; Male; Neurons; Neuropeptides; Orexin Receptors; Orexins; Propofol; Pyridazines; Rats; Rats, Wistar; Receptors, G-Protein-Coupled; Receptors, GABA-A; Receptors, Neuropeptide

2005
Behavior and cellular evidence for propofol-induced hypnosis involving brain glycine receptors.
    Anesthesiology, 2009, Volume: 110, Issue:2

    Topics: Anesthetics, Intravenous; Animals; Behavior, Animal; Brain Chemistry; Catheterization; Dose-Response Relationship, Drug; Electrophysiology; Excitatory Amino Acid Antagonists; Female; GABA Antagonists; GABA-A Receptor Antagonists; Glycine Agents; Hypothalamus, Posterior; Ketamine; Neurons; Patch-Clamp Techniques; Postural Balance; Propofol; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, Glycine; Reflex; Strychnine

2009
Endogenous gamma-aminobutyric acid modulates tonic guinea pig airway tone and propofol-induced airway smooth muscle relaxation.
    Anesthesiology, 2009, Volume: 110, Issue:4

    Topics: Acetylcholine; Anesthetics, Intravenous; Animals; Chromatography, High Pressure Liquid; Dose-Response Relationship, Drug; GABA Agonists; GABA Antagonists; gamma-Aminobutyric Acid; Guinea Pigs; Immunohistochemistry; Male; Models, Animal; Muscimol; Muscle Relaxation; Muscle, Smooth; Propofol; Pyridazines; Random Allocation; Substance P; Trachea

2009
Propofol inhibits pressure-stimulated macrophage phagocytosis via the GABAA receptor and dysregulation of p130cas phosphorylation.
    American journal of physiology. Cell physiology, 2009, Volume: 296, Issue:6

    Topics: Anesthetics, Intravenous; Cell Line; Crk-Associated Substrate Protein; Dose-Response Relationship, Drug; GABA Antagonists; Humans; Macrophages; Phagocytosis; Phosphorylation; Picrotoxin; Pressure; Propofol; Pyridazines; Receptors, GABA-A; RNA Interference; RNA, Small Interfering; Signal Transduction; Stress, Mechanical; Time Factors

2009
Presynaptic actions of propofol enhance inhibitory synaptic transmission in isolated solitary tract nucleus neurons.
    Brain research, 2009, Aug-25, Volume: 1286

    Topics: Anesthetics, Intravenous; Animals; Bicuculline; Cells, Cultured; Furosemide; GABA Antagonists; Inhibitory Postsynaptic Potentials; Male; Neurons; Organ Culture Techniques; Patch-Clamp Techniques; Presynaptic Terminals; Propofol; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Sodium Potassium Chloride Symporter Inhibitors; Solitary Nucleus; Synaptic Transmission

2009
Propofol alters vesicular transport in rat cortical neuronal cultures.
    Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, 2011, Volume: 62, Issue:1

    Topics: Animals; Cells, Cultured; Cerebral Cortex; Molecular Motor Proteins; Neurites; Neuroglia; Neurons; Propofol; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A; Transport Vesicles

2011
Characterization of inhibitory GABA-A receptor activation during spreading depolarization in brain slice.
    PloS one, 2014, Volume: 9, Issue:10

    Topics: Animals; CA1 Region, Hippocampal; GABA Agonists; GABA Antagonists; Membrane Potentials; Mice, Inbred C57BL; Neurons; Patch-Clamp Techniques; Propofol; Pyridazines; Receptors, GABA-A

2014
Propofol facilitates excitatory inputs of cerebellar Purkinje cells by depressing molecular layer interneuron activity during sensory information processing in vivo in mice.
    Neuroreport, 2015, Oct-21, Volume: 26, Issue:15

    Topics: Action Potentials; Afferent Pathways; Animals; Cerebellum; Female; GABA Antagonists; Hypnotics and Sedatives; Interneurons; Male; Mice; Mice, Inbred ICR; Patch-Clamp Techniques; Physical Stimulation; Propofol; Purkinje Cells; Pyridazines

2015
Propofol Causes Consciousness Loss by Affecting GABA-A Receptor in the Nucleus Basalis of Rats.
    Behavioural neurology, 2020, Volume: 2020

    Topics: Animals; Basal Nucleus of Meynert; Consciousness; Electroencephalography; Male; Muscimol; Propofol; Pyridazines; Rats; Rats, Sprague-Dawley; Receptors, GABA-A

2020