Page last updated: 2024-09-03

piperaquine and quinine

piperaquine has been researched along with quinine in 31 studies

Compound Research Comparison

Studies
(piperaquine)
Trials
(piperaquine)
Recent Studies (post-2010)
(piperaquine)
Studies
(quinine)
Trials
(quinine)
Recent Studies (post-2010) (quinine)
6382274976,8593981,099

Protein Interaction Comparison

ProteinTaxonomypiperaquine (IC50)quinine (IC50)
Solute carrier family 22 member 1Mus musculus (house mouse)0.28
Solute carrier family 22 member 2Mus musculus (house mouse)2.8
Potassium channel subfamily K member 2Homo sapiens (human)3.85
ATP-dependent translocase ABCB1Homo sapiens (human)1.7
Cytochrome P450 2D26Rattus norvegicus (Norway rat)0.094
Cytochrome P450 2D6Homo sapiens (human)0.6285
Solute carrier family 22 member 1Rattus norvegicus (Norway rat)2.0333
Cytochrome P450 2D4Rattus norvegicus (Norway rat)1.7

Research

Studies (31)

TimeframeStudies, this research(%)All Research%
pre-19902 (6.45)18.7374
1990's1 (3.23)18.2507
2000's5 (16.13)29.6817
2010's19 (61.29)24.3611
2020's4 (12.90)2.80

Authors

AuthorsStudies
Masseno, V; Muriithi, S; Nzila, A1
Greenhouse, B; Joloba, M; Kiggundu, M; Nanyunja, S; Nsobya, SL; Rosenthal, PJ1
Borrmann, S; Kiara, SM; Mwai, L; Nzila, A; Ochola, LI; Ohuma, E; Okombo, J; Pole, L; Rono, J1
Amalvict, R; Baret, E; Briolant, S; Didillon, E; Henry, M; Oeuvray, C; Pradines, B; Rogier, C1
Fidock, DA; Flannery, EL; Winzeler, EA1
Bane, CE; Black, C; Butler, K; Caridha, D; Cooper, RA; Dodean, RA; Gaona, H; Gaynor-Ohnstad, L; Huezo, SJ; Kancharla, P; Kelly, JX; Kreishman-Deitrick, M; Leed, SE; Li, Q; Li, Y; Lin, H; Luong, TL; Marcsisin, S; Melendez, V; Nolan, C; Olmeda, R; Potter, B; Pou, S; Rasmussen, SA; Read, L; Riscoe, MK; Roncal, N; Sciotti, RJ; Smilkstein, MJ; Sousa, J; Stephens, MT; Tan, JC; Vesely, B; Vuong, C; Winter, RW; Xie, L; Zeng, Q; Zhang, J; Zhang, P1
Cheong, SL; Ng, CH; Tibon, NS1
Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA1
Biaud, JM; Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA1
Huang, K; Liao, M; Liu, D; Yang, H; Yang, P; Yang, Y; Zhang, C1
Diallo, TO; Doui-Doumgba, K; Flori, P; Garraud, O; Gbagba, FE; Nambei, WS; Ndadjimbaye, V; Ndémanga, J; Perraut, R1
Brzostowski, JA; Kimmel, AR; Naudé, B; Wellems, TE1
Huang, CZ; Li, YF; Zhang, Q1
Brun, R; Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, MK; Smilkstein, MJ; Winter, R; Wittlin, S1
Ariey, F; Beck, HP; Decosterd, LA; Duong, S; Genton, B; Hodel, EM; Mercier, T; Olliaro, P; Zanolari, B1
Chaisri, U; Chotivanich, K; Day, NP; Ferguson, DJ; Pongponratn, E; Sachanonta, N; Turner, GD1
Chaisri, U; Day, NP; Dondorp, A; Silamut, K; Wongtanachai, J1
Baird, JK; Basri, H; Ekawati, LL; Elyazar, I; Farrar, J; Meilia, RA; Nurleila, S; Putri, FA; Setiabudy, R; Sudoyo, H; Sutanto, I; Taylor, WR; Tjahjono, B1
Beeson, JG; Goodman, CD; Langer, C; McFadden, GI; Wilson, DW1
Achan, J; D'Alessandro, U; Talisuna, AO; Tibenderana, J; Yeka, A1
Bigira, V; Bloome, J; Byaruhanga, O; Conrad, MD; Cooper, RA; Dorsey, G; Greenhouse, B; Gut, J; Havlir, DV; Kakuru, A; Kamya, MR; Kapisi, J; Kozak, B; LeClair, N; Legac, J; Nakazibwe, C; Nsobya, SL; Okiring, J; Rosenthal, PJ; Tumwebaze, P; Walakira, A1
Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA1
Clark, RL1
Agarwal, P; Anvikar, AR; Pillai, CR; Srivastava, K1
Aol, G; Bigogo, GM; Desai, M; Hill, J; Laserson, KF; Phillips-Howard, PA; Taegtmeyer, M; Ter Kuile, F; Young, N1
Garrido Jareño, M; Otero Reigada, MDC; Peman García, J; Ramírez Cuentas, JH; Roselló Guijarro, M; Urtasun Erburu, A1
Blessborn, D; Byakika-Kibwika, P; Lamorde, M; Ssenyonga, R; Tarning, J1
Ahmad, RA; Kenangalem, E; Laksono, IS; Lampah, DA; Murhandarwati, EEH; Poespoprodjo, JR; Sikora, SA; Sugiarto, P1
Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J1
Bah, S; Dabitao, D; Dama, S; Diakité, M; Diakité, SAS; Doumbia, S; Doumbouya, M; Guindo, MA; Keita, B; Konaté, DS; Sangaré, M; Sanogo, I; Traoré, K1

Reviews

4 review(s) available for piperaquine and quinine

ArticleYear
Using genetic methods to define the targets of compounds with antimalarial activity.
    Journal of medicinal chemistry, 2013, Oct-24, Volume: 56, Issue:20

    Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum

2013
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
    European journal of medicinal chemistry, 2020, Feb-15, Volume: 188

    Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines

2020
Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester.
    Birth defects research, 2017, Aug-15, Volume: 109, Issue:14

    Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Combinations; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pregnancy; Pregnancy Trimester, First; Pyrimethamine; Quinine; Quinolines; Rabbits; Rats; Sulfadoxine; Teratogens

2017
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
    The Lancet. Infectious diseases, 2020, Volume: 20, Issue:8

    Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine

2020

Trials

5 trial(s) available for piperaquine and quinine

ArticleYear
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:3

    Topics: Antimalarials; Child; Child, Preschool; Cohort Studies; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Treatment Outcome; Uganda

2010
Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.
    Parasite (Paris, France), 2005, Volume: 12, Issue:1

    Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Central African Republic; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Parasitemia; Parasitic Sensitivity Tests; Patient Compliance; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Sesquiterpenes; Sulfadoxine; Treatment Outcome; Trimethoprim

2005
Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:3

    Topics: Adult; Antimalarials; Artemisinins; Artesunate; Drug Administration Schedule; Drug Dosage Calculations; Drug Resistance; Drug Therapy, Combination; Humans; Indonesia; Malaria; Malaria, Vivax; Male; Military Personnel; Plasmodium vivax; Primaquine; Quinine; Quinolines; Secondary Prevention

2013
Efficacy of quinine, artemether-lumefantrine and dihydroartemisinin-piperaquine as rescue treatment for uncomplicated malaria in Ugandan children.
    PloS one, 2013, Volume: 8, Issue:1

    Topics: Antimalarials; Artemether; Artemisinins; Child, Preschool; Ethanolamines; Fluorenes; Humans; Infant; Lumefantrine; Malaria, Falciparum; Male; Quinine; Quinolines; Safety; Treatment Outcome; Uganda

2013
Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine.
    BMC infectious diseases, 2019, Dec-03, Volume: 19, Issue:1

    Topics: Administration, Intravenous; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Malaria, Falciparum; Male; Osmolar Concentration; Plasmodium falciparum; Quinine; Quinolines; Recurrence; Treatment Outcome; Uganda

2019

Other Studies

22 other study(ies) available for piperaquine and quinine

ArticleYear
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
    Antimicrobial agents and chemotherapy, 2009, Volume: 53, Issue:7

    Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil

2009
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:8

    Topics: Amino Acid Sequence; Animals; Antimalarials; Drug Resistance; Humans; Kenya; Mefloquine; Membrane Transport Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Sequence Analysis, DNA; Sodium-Hydrogen Exchangers

2010
Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2010, Volume: 54, Issue:9

    Topics: Animals; Antimalarials; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Protozoan Proteins; Quinolines

2010
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
    Journal of medicinal chemistry, 2019, 04-11, Volume: 62, Issue:7

    Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Malaria; Mice; Plasmodium; Species Specificity; Structure-Activity Relationship

2019
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs.
    Annals of tropical medicine and parasitology, 1985, Volume: 79, Issue:4

    Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Madagascar; Malaria; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines

1985
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of 2 years' study].
    Bulletin de la Societe de pathologie exotique et de ses filiales, 1985, Volume: 78, Issue:5

    Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; In Vitro Techniques; Madagascar; Malaria; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines

1985
[Assay of sensitivity of Plasmodium falciparum to chloroquine, amodiaquine, piperaquine, mefloquine and quinine in Yunnan province].
    Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases, 1999, Volume: 17, Issue:1

    Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

1999
Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.
    The Journal of biological chemistry, 2005, Jul-08, Volume: 280, Issue:27

    Topics: Acids; Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Cytoplasmic Vesicles; Dictyostelium; Drug Resistance, Bacterial; Gene Expression; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Phenotype; Phylogeny; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinidine; Quinine; Quinolines; Transfection

2005
Quality control of piperaquine in pharmaceutical formulations by capillary zone electrophoresis.
    Talanta, 2008, Jun-30, Volume: 76, Issue:1

    Topics: Adsorption; Antimalarials; Buffers; Electrophoresis, Capillary; Linear Models; Pharmaceutical Preparations; Pressure; Quality Control; Quinine; Quinolines; Reproducibility of Results; Sensitivity and Specificity; Temperature

2008
Discovery of dual function acridones as a new antimalarial chemotype.
    Nature, 2009, May-14, Volume: 459, Issue:7244

    Topics: Acridones; Animals; Antimalarials; Drug Discovery; Drug Resistance; Drug Synergism; Heme; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Plasmodium yoelii; Protozoan Proteins; Quinine; Quinolines; Trophozoites; Verapamil

2009
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.
    The Journal of infectious diseases, 2010, Oct-01, Volume: 202, Issue:7

    Topics: Adolescent; Adult; Antimalarials; Cambodia; Child; Child, Preschool; Chloroquine; Chromatography, Liquid; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinine; Quinolines; Selection, Genetic; Serum; Tandem Mass Spectrometry; Young Adult

2010
Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs.
    Ultrastructural pathology, 2011, Volume: 35, Issue:5

    Topics: Antimalarials; Artemisinins; Artesunate; Cells, Cultured; Erythrocytes; Host-Parasite Interactions; Malaria, Falciparum; Microscopy, Electron, Transmission; Plasmodium falciparum; Quinine; Quinolines; Ribosomes; Trophozoites

2011
Effects of antimalarial drugs on movement of Plasmodium falciparum.
    The Southeast Asian journal of tropical medicine and public health, 2012, Volume: 43, Issue:1

    Topics: Animals; Antimalarials; Artemisinins; Artesunate; In Vitro Techniques; Inhibitory Concentration 50; Microscopy; Movement; Plasmodium falciparum; Quinine; Quinolines; Trophozoites

2012
Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
    Antimicrobial agents and chemotherapy, 2013, Volume: 57, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Erythrocytes; Flow Cytometry; High-Throughput Screening Assays; Hydroxamic Acids; Inhibitory Concentration 50; Mefloquine; Merozoites; Plasmodium falciparum; Quinine; Quinolines; Schizonts; Time Factors

2013
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
    Antimicrobial agents and chemotherapy, 2015, Volume: 59, Issue:6

    Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Chloroquine; Clinical Trials as Topic; Ethanolamines; Fluorenes; Humans; Infant; Lumefantrine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Quinolines; Uganda

2015
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.
    Antimicrobial agents and chemotherapy, 2016, Volume: 60, Issue:8

    Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases

2016
Association between Polymorphisms in the Pf
    Antimicrobial agents and chemotherapy, 2017, Volume: 61, Issue:3

    Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal

2017
    The Indian journal of medical research, 2017, Volume: 146, Issue:5

    Topics: Anti-Bacterial Agents; Antimalarials; Artemether; Artemisinins; Atovaquone; Azithromycin; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Humans; India; Lumefantrine; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

2017
Integrated point-of-care testing (POCT) of HIV, syphilis, malaria and anaemia in antenatal clinics in western Kenya: A longitudinal implementation study.
    PloS one, 2018, Volume: 13, Issue:7

    Topics: Adult; Anemia; Anti-Bacterial Agents; Anti-HIV Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Dietary Supplements; Erythromycin; Female; Folic Acid; Guideline Adherence; Health Personnel; HIV Infections; Humans; Iron, Dietary; Kenya; Laboratory Proficiency Testing; Longitudinal Studies; Malaria; Penicillins; Point-of-Care Testing; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Complications, Infectious; Prenatal Care; Quinine; Quinolines; Syphilis; Trimethoprim, Sulfamethoxazole Drug Combination

2018
[Descriptive study of malaria cases in the paediatric population in a reference hospital in Valencia, Spain, between 1993 and 2015].
    Anales de pediatria, 2020, Volume: 92, Issue:1

    Topics: Adolescent; Age Distribution; Antimalarials; Artemisinins; Artesunate; Atovaquone; Child; Child, Preschool; Drug Combinations; Equatorial Guinea; Female; Hospitals, Community; Humans; Infant; Malaria; Male; Proguanil; Quinine; Quinolines; Retrospective Studies; Sex Distribution; Spain; Symptom Assessment

2020
Intravenous artesunate plus oral dihydroartemisinin-piperaquine or intravenous quinine plus oral quinine for optimum treatment of severe malaria: lesson learnt from a field hospital in Timika, Papua, Indonesia.
    Malaria journal, 2019, Dec-30, Volume: 18, Issue:1

    Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Female; Humans; Indonesia; Infant; Infant, Newborn; Malaria; Male; Middle Aged; Quinine; Quinolines; Retrospective Studies; Young Adult

2019
Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali.
    Drugs in R&D, 2020, Volume: 20, Issue:3

    Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mali; Mefloquine; Plasmodium falciparum; Quinine; Quinolines

2020