piperaquine and quinine
piperaquine has been researched along with quinine in 31 studies
Compound Research Comparison
| Studies (piperaquine) | Trials (piperaquine) | Recent Studies (post-2010) (piperaquine) | Studies (quinine) | Trials (quinine) | Recent Studies (post-2010) (quinine) |
|---|---|---|---|---|---|
| 638 | 227 | 497 | 6,859 | 398 | 1,099 |
Protein Interaction Comparison
| Protein | Taxonomy | piperaquine (IC50) | quinine (IC50) |
|---|---|---|---|
| Solute carrier family 22 member 1 | Mus musculus (house mouse) | 0.28 | |
| Solute carrier family 22 member 2 | Mus musculus (house mouse) | 2.8 | |
| Potassium channel subfamily K member 2 | Homo sapiens (human) | 3.85 | |
| ATP-dependent translocase ABCB1 | Homo sapiens (human) | 1.7 | |
| Cytochrome P450 2D26 | Rattus norvegicus (Norway rat) | 0.094 | |
| Cytochrome P450 2D6 | Homo sapiens (human) | 0.6285 | |
| Solute carrier family 22 member 1 | Rattus norvegicus (Norway rat) | 2.0333 | |
| Cytochrome P450 2D4 | Rattus norvegicus (Norway rat) | 1.7 |
Research
Studies (31)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (6.45) | 18.7374 |
| 1990's | 1 (3.23) | 18.2507 |
| 2000's | 5 (16.13) | 29.6817 |
| 2010's | 19 (61.29) | 24.3611 |
| 2020's | 4 (12.90) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Masseno, V; Muriithi, S; Nzila, A | 1 |
| Greenhouse, B; Joloba, M; Kiggundu, M; Nanyunja, S; Nsobya, SL; Rosenthal, PJ | 1 |
| Borrmann, S; Kiara, SM; Mwai, L; Nzila, A; Ochola, LI; Ohuma, E; Okombo, J; Pole, L; Rono, J | 1 |
| Amalvict, R; Baret, E; Briolant, S; Didillon, E; Henry, M; Oeuvray, C; Pradines, B; Rogier, C | 1 |
| Fidock, DA; Flannery, EL; Winzeler, EA | 1 |
| Bane, CE; Black, C; Butler, K; Caridha, D; Cooper, RA; Dodean, RA; Gaona, H; Gaynor-Ohnstad, L; Huezo, SJ; Kancharla, P; Kelly, JX; Kreishman-Deitrick, M; Leed, SE; Li, Q; Li, Y; Lin, H; Luong, TL; Marcsisin, S; Melendez, V; Nolan, C; Olmeda, R; Potter, B; Pou, S; Rasmussen, SA; Read, L; Riscoe, MK; Roncal, N; Sciotti, RJ; Smilkstein, MJ; Sousa, J; Stephens, MT; Tan, JC; Vesely, B; Vuong, C; Winter, RW; Xie, L; Zeng, Q; Zhang, J; Zhang, P | 1 |
| Cheong, SL; Ng, CH; Tibon, NS | 1 |
| Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA | 1 |
| Biaud, JM; Coulanges, P; Deloron, P; Le Bras, J; Ramanamirija, JA | 1 |
| Huang, K; Liao, M; Liu, D; Yang, H; Yang, P; Yang, Y; Zhang, C | 1 |
| Diallo, TO; Doui-Doumgba, K; Flori, P; Garraud, O; Gbagba, FE; Nambei, WS; Ndadjimbaye, V; Ndémanga, J; Perraut, R | 1 |
| Brzostowski, JA; Kimmel, AR; Naudé, B; Wellems, TE | 1 |
| Huang, CZ; Li, YF; Zhang, Q | 1 |
| Brun, R; Cooper, RA; Dodean, RA; Hinrichs, DJ; Janowsky, A; Johnson, RA; Kelly, JX; Lane, KD; Riscoe, MK; Smilkstein, MJ; Winter, R; Wittlin, S | 1 |
| Ariey, F; Beck, HP; Decosterd, LA; Duong, S; Genton, B; Hodel, EM; Mercier, T; Olliaro, P; Zanolari, B | 1 |
| Chaisri, U; Chotivanich, K; Day, NP; Ferguson, DJ; Pongponratn, E; Sachanonta, N; Turner, GD | 1 |
| Chaisri, U; Day, NP; Dondorp, A; Silamut, K; Wongtanachai, J | 1 |
| Baird, JK; Basri, H; Ekawati, LL; Elyazar, I; Farrar, J; Meilia, RA; Nurleila, S; Putri, FA; Setiabudy, R; Sudoyo, H; Sutanto, I; Taylor, WR; Tjahjono, B | 1 |
| Beeson, JG; Goodman, CD; Langer, C; McFadden, GI; Wilson, DW | 1 |
| Achan, J; D'Alessandro, U; Talisuna, AO; Tibenderana, J; Yeka, A | 1 |
| Bigira, V; Bloome, J; Byaruhanga, O; Conrad, MD; Cooper, RA; Dorsey, G; Greenhouse, B; Gut, J; Havlir, DV; Kakuru, A; Kamya, MR; Kapisi, J; Kozak, B; LeClair, N; Legac, J; Nakazibwe, C; Nsobya, SL; Okiring, J; Rosenthal, PJ; Tumwebaze, P; Walakira, A | 1 |
| Amalvict, R; Benoit, N; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA | 1 |
| Amalvict, R; Benoit, N; Briolant, S; Diatta, B; Diawara, S; Diémé, Y; Fall, B; Fall, M; Gendrot, M; Kounta, MB; Madamet, M; Nakoulima, A; Pradines, B; Wade, B; Wade, KA | 1 |
| Clark, RL | 1 |
| Agarwal, P; Anvikar, AR; Pillai, CR; Srivastava, K | 1 |
| Aol, G; Bigogo, GM; Desai, M; Hill, J; Laserson, KF; Phillips-Howard, PA; Taegtmeyer, M; Ter Kuile, F; Young, N | 1 |
| Garrido Jareño, M; Otero Reigada, MDC; Peman García, J; Ramírez Cuentas, JH; Roselló Guijarro, M; Urtasun Erburu, A | 1 |
| Blessborn, D; Byakika-Kibwika, P; Lamorde, M; Ssenyonga, R; Tarning, J | 1 |
| Ahmad, RA; Kenangalem, E; Laksono, IS; Lampah, DA; Murhandarwati, EEH; Poespoprodjo, JR; Sikora, SA; Sugiarto, P | 1 |
| Anvikar, AR; Ashley, EA; Chandramohan, D; Cohee, LM; D'Alessandro, U; Genton, B; Gilder, ME; Guérin, PJ; Juma, E; Kalilani-Phiri, L; Kennon, K; Kuepfer, I; Laufer, MK; Lwin, KM; Mansoor, R; McGready, R; Meshnick, SR; Mosha, D; Mwapasa, V; Mwebaza, N; Nambozi, M; Ndiaye, JA; Nosten, F; Nyunt, M; Ogutu, B; Parikh, S; Paw, MK; Phyo, AP; Pimanpanarak, M; Piola, P; Rijken, MJ; Saito, M; Sriprawat, K; Stepniewska, K; Tagbor, HK; Tarning, J; Tinto, H; Valéa, I; Valecha, N; White, NJ; Wiladphaingern, J | 1 |
| Bah, S; Dabitao, D; Dama, S; Diakité, M; Diakité, SAS; Doumbia, S; Doumbouya, M; Guindo, MA; Keita, B; Konaté, DS; Sangaré, M; Sanogo, I; Traoré, K | 1 |
Reviews
4 review(s) available for piperaquine and quinine
| Article | Year |
|---|---|
Using genetic methods to define the targets of compounds with antimalarial activity.
Topics: Animals; Anopheles; Antimalarials; Drug Resistance; Genetic Association Studies; Genome, Protozoan; Humans; Malaria, Falciparum; Molecular Targeted Therapy; Plasmodium falciparum | 2013 |
Current progress in antimalarial pharmacotherapy and multi-target drug discovery.
Topics: Animals; Antimalarials; Artemisinins; Drug Discovery; Drug Resistance; Humans; Malaria; Molecular Structure; Paclitaxel; Quinolines | 2020 |
Animal Embryotoxicity Studies of Key Non-Artemisinin Antimalarials and Use in Women in the First Trimester.
Topics: Amodiaquine; Animals; Antimalarials; Artemisinins; Drug Combinations; Female; Humans; Malaria; Malaria, Falciparum; Naphthyridines; Pregnancy; Pregnancy Trimester, First; Pyrimethamine; Quinine; Quinolines; Rabbits; Rats; Sulfadoxine; Teratogens | 2017 |
Efficacy and tolerability of artemisinin-based and quinine-based treatments for uncomplicated falciparum malaria in pregnancy: a systematic review and individual patient data meta-analysis.
Topics: Amodiaquine; Anti-Bacterial Agents; Antimalarials; Artemisinins; Artesunate; Atovaquone; Clindamycin; Drug Combinations; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Mefloquine; Pregnancy; Pregnancy Complications, Parasitic; Proguanil; Pyrimethamine; Quinine; Quinolines; Sulfadoxine | 2020 |
Trials
5 trial(s) available for piperaquine and quinine
| Article | Year |
|---|---|
In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.
Topics: Antimalarials; Child; Child, Preschool; Cohort Studies; Drug Resistance; Humans; Malaria, Falciparum; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Treatment Outcome; Uganda | 2010 |
Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.
Topics: Adolescent; Adult; Animals; Antimalarials; Artemisinins; Central African Republic; Drug Combinations; Drug Resistance; Drug Therapy, Combination; Female; Humans; Malaria, Falciparum; Male; Parasitemia; Parasitic Sensitivity Tests; Patient Compliance; Plasmodium falciparum; Pyrimethamine; Quinine; Quinolines; Sesquiterpenes; Sulfadoxine; Treatment Outcome; Trimethoprim | 2005 |
Randomized, open-label trial of primaquine against vivax malaria relapse in Indonesia.
Topics: Adult; Antimalarials; Artemisinins; Artesunate; Drug Administration Schedule; Drug Dosage Calculations; Drug Resistance; Drug Therapy, Combination; Humans; Indonesia; Malaria; Malaria, Vivax; Male; Military Personnel; Plasmodium vivax; Primaquine; Quinine; Quinolines; Secondary Prevention | 2013 |
Efficacy of quinine, artemether-lumefantrine and dihydroartemisinin-piperaquine as rescue treatment for uncomplicated malaria in Ugandan children.
Topics: Antimalarials; Artemether; Artemisinins; Child, Preschool; Ethanolamines; Fluorenes; Humans; Infant; Lumefantrine; Malaria, Falciparum; Male; Quinine; Quinolines; Safety; Treatment Outcome; Uganda | 2013 |
Piperaquine concentration and malaria treatment outcomes in Ugandan children treated for severe malaria with intravenous Artesunate or quinine plus Dihydroartemisinin-Piperaquine.
Topics: Administration, Intravenous; Antimalarials; Artemisinins; Artesunate; Child, Preschool; Female; Follow-Up Studies; Humans; Infant; Malaria, Falciparum; Male; Osmolar Concentration; Plasmodium falciparum; Quinine; Quinolines; Recurrence; Treatment Outcome; Uganda | 2019 |
Other Studies
22 other study(ies) available for piperaquine and quinine
| Article | Year |
|---|---|
In vitro chemosensitization of Plasmodium falciparum to antimalarials by verapamil and probenecid.
Topics: Adjuvants, Pharmaceutic; Animals; Antimalarials; Parasitic Sensitivity Tests; Plasmodium falciparum; Probenecid; Verapamil | 2009 |
In vitro activities of quinine and other antimalarials and pfnhe polymorphisms in Plasmodium isolates from Kenya.
Topics: Amino Acid Sequence; Animals; Antimalarials; Drug Resistance; Humans; Kenya; Mefloquine; Membrane Transport Proteins; Molecular Sequence Data; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Phenanthrenes; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Sequence Analysis, DNA; Sodium-Hydrogen Exchangers | 2010 |
Absence of association between piperaquine in vitro responses and polymorphisms in the pfcrt, pfmdr1, pfmrp, and pfnhe genes in Plasmodium falciparum.
Topics: Animals; Antimalarials; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Plasmodium falciparum; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Protozoan Proteins; Quinolines | 2010 |
Discovery and Structural Optimization of Acridones as Broad-Spectrum Antimalarials.
Topics: Acridones; Animals; Antimalarials; Disease Models, Animal; Drug Discovery; Hep G2 Cells; Humans; Malaria; Mice; Plasmodium; Species Specificity; Structure-Activity Relationship | 2019 |
Plasmodium falciparum in Madagascar: in vivo and in vitro sensitivity to seven drugs.
Topics: Adolescent; Adult; Aged; Amodiaquine; Antimalarials; Child; Child, Preschool; Chloroquine; Humans; Infant; Madagascar; Malaria; Mefloquine; Microbial Sensitivity Tests; Middle Aged; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines | 1985 |
[In vivo and in vitro sensitivity to 4-aminoquinolines of Plasmodium falciparum in Madagascar: results of 2 years' study].
Topics: Aminoquinolines; Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance, Microbial; Humans; In Vitro Techniques; Madagascar; Malaria; Phenanthrenes; Piperazines; Plasmodium falciparum; Quinine; Quinolines | 1985 |
[Assay of sensitivity of Plasmodium falciparum to chloroquine, amodiaquine, piperaquine, mefloquine and quinine in Yunnan province].
Topics: Amodiaquine; Animals; Antimalarials; Chloroquine; Drug Resistance; Mefloquine; Plasmodium falciparum; Quinine; Quinolines | 1999 |
Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.
Topics: Acids; Amino Acid Sequence; Animals; Antimalarials; Chloroquine; Cytoplasmic Vesicles; Dictyostelium; Drug Resistance, Bacterial; Gene Expression; Membrane Proteins; Membrane Transport Proteins; Molecular Sequence Data; Phenotype; Phylogeny; Plasmodium falciparum; Point Mutation; Protozoan Proteins; Quinidine; Quinine; Quinolines; Transfection | 2005 |
Quality control of piperaquine in pharmaceutical formulations by capillary zone electrophoresis.
Topics: Adsorption; Antimalarials; Buffers; Electrophoresis, Capillary; Linear Models; Pharmaceutical Preparations; Pressure; Quality Control; Quinine; Quinolines; Reproducibility of Results; Sensitivity and Specificity; Temperature | 2008 |
Discovery of dual function acridones as a new antimalarial chemotype.
Topics: Acridones; Animals; Antimalarials; Drug Discovery; Drug Resistance; Drug Synergism; Heme; Membrane Transport Proteins; Mutation; Plasmodium falciparum; Plasmodium yoelii; Protozoan Proteins; Quinine; Quinolines; Trophozoites; Verapamil | 2009 |
Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.
Topics: Adolescent; Adult; Antimalarials; Cambodia; Child; Child, Preschool; Chloroquine; Chromatography, Liquid; Drug Resistance; Female; Humans; Malaria, Falciparum; Male; Mefloquine; Middle Aged; Quinine; Quinolines; Selection, Genetic; Serum; Tandem Mass Spectrometry; Young Adult | 2010 |
Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs.
Topics: Antimalarials; Artemisinins; Artesunate; Cells, Cultured; Erythrocytes; Host-Parasite Interactions; Malaria, Falciparum; Microscopy, Electron, Transmission; Plasmodium falciparum; Quinine; Quinolines; Ribosomes; Trophozoites | 2011 |
Effects of antimalarial drugs on movement of Plasmodium falciparum.
Topics: Animals; Antimalarials; Artemisinins; Artesunate; In Vitro Techniques; Inhibitory Concentration 50; Microscopy; Movement; Plasmodium falciparum; Quinine; Quinolines; Trophozoites | 2012 |
Defining the timing of action of antimalarial drugs against Plasmodium falciparum.
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Chloroquine; Erythrocytes; Flow Cytometry; High-Throughput Screening Assays; Hydroxamic Acids; Inhibitory Concentration 50; Mefloquine; Merozoites; Plasmodium falciparum; Quinine; Quinolines; Schizonts; Time Factors | 2013 |
Impact of antimalarial treatment and chemoprevention on the drug sensitivity of malaria parasites isolated from ugandan children.
Topics: Amodiaquine; Antimalarials; Artemisinins; Child, Preschool; Chloroquine; Clinical Trials as Topic; Ethanolamines; Fluorenes; Humans; Infant; Lumefantrine; Membrane Transport Proteins; Multidrug Resistance-Associated Proteins; Parasitic Sensitivity Tests; Plasmodium falciparum; Polymorphism, Genetic; Protozoan Proteins; Quinine; Quinolines; Uganda | 2015 |
Absence of Association between Polymorphisms in the RING E3 Ubiquitin Protein Ligase Gene and Ex Vivo Susceptibility to Conventional Antimalarial Drugs in Plasmodium falciparum Isolates from Dakar, Senegal.
Topics: Antimalarials; Artemisinins; Artesunate; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Lumefantrine; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Quinine; Quinolines; Senegal; Ubiquitin-Protein Ligases | 2016 |
Association between Polymorphisms in the Pf
Topics: Amodiaquine; Antimalarials; Artemisinins; Artesunate; Asparagine; ATP-Binding Cassette Transporters; Chloroquine; Doxycycline; Drug Resistance; Ethanolamines; Fluorenes; Gene Expression; Humans; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mefloquine; Naphthyridines; Plasmodium falciparum; Polymorphism, Genetic; Protein Isoforms; Protozoan Proteins; Quinine; Quinolines; Repetitive Sequences, Amino Acid; Senegal | 2017 |
Topics: Anti-Bacterial Agents; Antimalarials; Artemether; Artemisinins; Atovaquone; Azithromycin; Chloroquine; Doxycycline; Ethanolamines; Fluorenes; Humans; India; Lumefantrine; Malaria, Falciparum; Mefloquine; Plasmodium falciparum; Quinine; Quinolines | 2017 |
Integrated point-of-care testing (POCT) of HIV, syphilis, malaria and anaemia in antenatal clinics in western Kenya: A longitudinal implementation study.
Topics: Adult; Anemia; Anti-Bacterial Agents; Anti-HIV Agents; Antimalarials; Artemether, Lumefantrine Drug Combination; Artemisinins; Dietary Supplements; Erythromycin; Female; Folic Acid; Guideline Adherence; Health Personnel; HIV Infections; Humans; Iron, Dietary; Kenya; Laboratory Proficiency Testing; Longitudinal Studies; Malaria; Penicillins; Point-of-Care Testing; Pregnancy; Pregnancy Complications, Hematologic; Pregnancy Complications, Infectious; Prenatal Care; Quinine; Quinolines; Syphilis; Trimethoprim, Sulfamethoxazole Drug Combination | 2018 |
[Descriptive study of malaria cases in the paediatric population in a reference hospital in Valencia, Spain, between 1993 and 2015].
Topics: Adolescent; Age Distribution; Antimalarials; Artemisinins; Artesunate; Atovaquone; Child; Child, Preschool; Drug Combinations; Equatorial Guinea; Female; Hospitals, Community; Humans; Infant; Malaria; Male; Proguanil; Quinine; Quinolines; Retrospective Studies; Sex Distribution; Spain; Symptom Assessment | 2020 |
Intravenous artesunate plus oral dihydroartemisinin-piperaquine or intravenous quinine plus oral quinine for optimum treatment of severe malaria: lesson learnt from a field hospital in Timika, Papua, Indonesia.
Topics: Administration, Intravenous; Administration, Oral; Adolescent; Adult; Aged; Aged, 80 and over; Antimalarials; Artemisinins; Artesunate; Child; Child, Preschool; Drug Combinations; Female; Humans; Indonesia; Infant; Infant, Newborn; Malaria; Male; Middle Aged; Quinine; Quinolines; Retrospective Studies; Young Adult | 2019 |
Ex-vivo Sensitivity of Plasmodium falciparum to Common Anti-malarial Drugs: The Case of Kéniéroba, a Malaria Endemic Village in Mali.
Topics: Adolescent; Amodiaquine; Antimalarials; Artemisinins; Child; Child, Preschool; Chloroquine; Drug Resistance; Endemic Diseases; Humans; Infant; Inhibitory Concentration 50; Lumefantrine; Malaria, Falciparum; Mali; Mefloquine; Plasmodium falciparum; Quinine; Quinolines | 2020 |