mk 0663 has been researched along with trazodone in 3 studies
| Studies (mk 0663) | Trials (mk 0663) | Recent Studies (post-2010) (mk 0663) | Studies (trazodone) | Trials (trazodone) | Recent Studies (post-2010) (trazodone) |
|---|---|---|---|---|---|
| 549 | 173 | 265 | 1,466 | 295 | 312 |
| Protein | Taxonomy | mk 0663 (IC50) | trazodone (IC50) |
|---|---|---|---|
| 5-hydroxytryptamine receptor 4 | Cavia porcellus (domestic guinea pig) | 0.091 | |
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.909 | |
| D(2) dopamine receptor | Homo sapiens (human) | 4.485 | |
| 5-hydroxytryptamine receptor 2A | Rattus norvegicus (Norway rat) | 0.017 | |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.281 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.389 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 1.942 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 0.311 | |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | 0.281 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 0.265 | |
| 5-hydroxytryptamine receptor 2A | Homo sapiens (human) | 0.1315 | |
| 5-hydroxytryptamine receptor 2C | Homo sapiens (human) | 0.091 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 0.311 | |
| Sodium-dependent serotonin transporter | Homo sapiens (human) | 0.192 | |
| Histamine H1 receptor | Homo sapiens (human) | 0.361 | |
| D(3) dopamine receptor | Homo sapiens (human) | 3.743 | |
| 5-hydroxytryptamine receptor 2B | Homo sapiens (human) | 0.107 | |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.281 | |
| Sigma non-opioid intracellular receptor 1 | Homo sapiens (human) | 2.203 |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (33.33) | 29.6817 |
| 2010's | 2 (66.67) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Lombardo, F; Obach, RS; Waters, NJ | 1 |
| Afshari, CA; Eschenberg, M; Hamadeh, HK; Lee, PH; Lightfoot-Dunn, R; Morgan, RE; Qualls, CW; Ramachandran, B; Trauner, M; van Staden, CJ | 1 |
| Afshari, CA; Chen, Y; Dunn, RT; Hamadeh, HK; Kalanzi, J; Kalyanaraman, N; Morgan, RE; van Staden, CJ | 1 |
3 other study(ies) available for mk 0663 and trazodone
| Article | Year |
|---|---|
Trend analysis of a database of intravenous pharmacokinetic parameters in humans for 670 drug compounds.
Topics: Blood Proteins; Half-Life; Humans; Hydrogen Bonding; Infusions, Intravenous; Pharmacokinetics; Protein Binding | 2008 |
Interference with bile salt export pump function is a susceptibility factor for human liver injury in drug development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Assay; Biological Transport; Cell Line; Cell Membrane; Chemical and Drug Induced Liver Injury; Cytoplasmic Vesicles; Drug Evaluation, Preclinical; Humans; Liver; Rats; Reproducibility of Results; Spodoptera; Transfection; Xenobiotics | 2010 |
A multifactorial approach to hepatobiliary transporter assessment enables improved therapeutic compound development.
Topics: Animals; ATP Binding Cassette Transporter, Subfamily B; ATP Binding Cassette Transporter, Subfamily B, Member 11; ATP-Binding Cassette Transporters; Biological Transport; Chemical and Drug Induced Liver Injury; Cluster Analysis; Drug-Related Side Effects and Adverse Reactions; Humans; Liver; Male; Multidrug Resistance-Associated Proteins; Pharmacokinetics; Rats; Rats, Sprague-Dawley; Recombinant Proteins; Risk Assessment; Risk Factors; Toxicity Tests | 2013 |