l 659066 and clonidine
l 659066 has been researched along with clonidine in 4 studies
Compound Research Comparison
| Studies (l 659066) | Trials (l 659066) | Recent Studies (post-2010) (l 659066) | Studies (clonidine) | Trials (clonidine) | Recent Studies (post-2010) (clonidine) |
|---|---|---|---|---|---|
| 79 | 40 | 57 | 13,692 | 2,044 | 1,394 |
Protein Interaction Comparison
| Protein | Taxonomy | l 659066 (IC50) | clonidine (IC50) |
|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | 0.101 | |
| Alpha-2B adrenergic receptor | Homo sapiens (human) | 0.0353 | |
| Alpha-2C adrenergic receptor | Homo sapiens (human) | 0.0115 | |
| 5-hydroxytryptamine receptor 1A | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2B adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2C adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-2A adrenergic receptor | Rattus norvegicus (Norway rat) | 0.0173 | |
| Alpha-1D adrenergic receptor | Homo sapiens (human) | 1.21 | |
| 5-hydroxytryptamine receptor 1B | Rattus norvegicus (Norway rat) | 5.365 | |
| Alpha-2A adrenergic receptor | Bos taurus (cattle) | 0.002 | |
| Nischarin | Rattus norvegicus (Norway rat) | 0.3662 |
Research
Studies (4)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Dollery, CT; Goldberg, MR; Sciberras, D; Warren, JB | 1 |
| Clineschmidt, BV; Hucker, HB; Huff, JR; Lis, EV; Lotti, VJ; Pettibone, DJ; Reiss, DR; Sweeney, BM; Vacca, J | 1 |
| Alila-Johansson, A; Hätönen, T; Laakso, M; Mustanoja, SM | 1 |
| Bilge, SS; Bostanci, MO; Bozkurt, A; Ciftcioglu, E; Dilek, A; Güldogus, F; Ilkaya, F; Ulger, F | 1 |
Trials
1 trial(s) available for l 659066 and clonidine
| Article | Year |
|---|---|
Assessment of MK-467, a peripheral alpha 2-adrenergic receptor antagonist, with intravenous clonidine.
Topics: Administration, Oral; Adrenergic alpha-Antagonists; Adult; Blood Glucose; Blood Pressure; Clonidine; Dose-Response Relationship, Drug; Double-Blind Method; Humans; Insulin; Male; Norepinephrine; Quinolizines; Random Allocation; Salivation | 1991 |
Other Studies
3 other study(ies) available for l 659066 and clonidine
| Article | Year |
|---|---|
A peripherally acting alpha-2 adrenoceptor antagonist: L-659,066.
Topics: Adrenergic alpha-Antagonists; Animals; Binding, Competitive; Blood-Brain Barrier; Callitrichinae; Clonidine; Decerebrate State; Dihydroxyphenylalanine; Gastrointestinal Motility; Male; Muscle Contraction; Quinolizines; Rats; Rats, Inbred Strains; Receptors, Adrenergic, alpha; Vas Deferens; Yohimbine | 1988 |
Evidence for central alpha(2)-adrenergic modulation of rat pineal melatonin synthesis.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Animals; Circadian Rhythm; Clonidine; Male; Medetomidine; Melatonin; Pineal Gland; Quinolizines; Rats; Rats, Wistar; Receptors, Adrenergic, alpha-2; Yohimbine | 2000 |
The antinociceptive effects of intravenous dexmedetomidine in colorectal distension-induced visceral pain in rats: the role of opioid receptors.
Topics: Adrenergic alpha-Agonists; Adrenergic alpha-Antagonists; Analgesics, Non-Narcotic; Animals; Catheterization; Clonidine; Colon; Data Interpretation, Statistical; Dexmedetomidine; Dose-Response Relationship, Drug; Injections, Intravenous; Male; Naloxone; Narcotic Antagonists; Pain; Pain Measurement; Physical Stimulation; Quinolizines; Rats; Rats, Sprague-Dawley; Receptors, Opioid; Rectum; Yohimbine | 2009 |