Compounds > gw420867x
Page last updated: 2024-09-04

gw420867x and efavirenz

gw420867x has been researched along with efavirenz in 5 studies

Compound Research Comparison

Studies
(gw420867x)		Trials
(gw420867x)		Recent Studies (post-2010)
(gw420867x)		Studies
(efavirenz)		Trials
(efavirenz)		Recent Studies (post-2010) (efavirenz)
17523,1106311,611

Protein Interaction Comparison

ProteinTaxonomygw420867x (IC50)efavirenz (IC50)
Chain A, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain A, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain B, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain A, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain B, POL POLYPROTEINHuman immunodeficiency virus 10.2612
Chain A, Pol PolyproteinHuman immunodeficiency virus 10.2612
Chain B, Pol PolyproteinHuman immunodeficiency virus 10.2612
Prothrombin Bos taurus (cattle)0.022
Gag-Pol polyproteinHIV-1 M:B_HXB2R0.1852
Gag-Pol polyproteinHuman immunodeficiency virus type 1 (NEW YORK-5 ISOLATE)0.02
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.018
Microsomal triglyceride transfer protein large subunitHomo sapiens (human)0.054
Disintegrin and metalloproteinase domain-containing protein 17Homo sapiens (human)0.004
Envelope glycoprotein gp160 [Cleaved into: Surface protein gp120 Human immunodeficiency virus 10.0035
Reverse transcriptase/RNaseH Human immunodeficiency virus 10.1627
Reverse transcriptase Human immunodeficiency virus 10.0643

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (80.00)29.6817
2010's1 (20.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Cordova, BC; Erickson-Viitanen, S; Klabe, RM; McHugh, RJ; Patel, M; Rodgers, JD; Trainor, GL1
Jorgensen, WL; Kroeger Smith, MB; Rizzo, RC; Smith, RH; Tirado-Rives, J; Udier-Blagović, M; Wang, DP; Watkins, EK1
Bastos, MM; Bezerra, TC; Boechat, N; Costa, CCP; da Silva, FC1
Duval, X1
Balzarini, J; Burt, V; Carbonez, A; De Clercq, E; Kleim, JP1

Reviews

1 review(s) available for gw420867x and efavirenz

ArticleYear
Efavirenz a nonnucleoside reverse transcriptase inhibitor of first-generation: Approaches based on its medicinal chemistry.
    European journal of medicinal chemistry, 2016, Jan-27, Volume: 108

    Topics: Alkynes; Anti-HIV Agents; Benzoxazines; Chemistry, Pharmaceutical; Cyclopropanes; HIV Reverse Transcriptase; HIV-1; Humans; Molecular Conformation; Reverse Transcriptase Inhibitors; Structure-Activity Relationship

2016

Other Studies

4 other study(ies) available for gw420867x and efavirenz

ArticleYear
Synthesis and evaluation of quinoxalinones as HIV-1 reverse transcriptase inhibitors.
    Bioorganic & medicinal chemistry letters, 2000, Aug-07, Volume: 10, Issue:15

    Topics: Drug Evaluation; HIV Reverse Transcriptase; Quinoxalines; Reverse Transcriptase Inhibitors

2000
Prediction of activity for nonnucleoside inhibitors with HIV-1 reverse transcriptase based on Monte Carlo simulations.
    Journal of medicinal chemistry, 2002, Jul-04, Volume: 45, Issue:14

    Topics: Alkynes; Anilides; Benzoxazines; Computer Simulation; Cyclopropanes; HIV Reverse Transcriptase; Hydrogen Bonding; Models, Molecular; Monte Carlo Method; Nevirapine; Oxazines; Protein Binding; Quinoxalines; Regression Analysis; Reverse Transcriptase Inhibitors; Structure-Activity Relationship; Uracil

2002
[The 39th ICAAC (San Francisco) and the 7th European Conference on Clinical Aspects and Treatment of HIV-infection (Lisbon). HIV infection: antiretroviral agents in the development and trial stage].
    Presse medicale (Paris, France : 1983), 2000, Feb-12, Volume: 29, Issue:5

    Topics: Alkynes; Animals; Anti-HIV Agents; Antiviral Agents; Benzoxazines; Clinical Trials as Topic; Cyclopropanes; Drug Therapy, Combination; HIV; HIV Infections; HIV Protease Inhibitors; Humans; Oxazines; Quinoxalines; Reverse Transcriptase Inhibitors; Time Factors; Uracil; Viral Load

2000
Long-term exposure of HIV type 1-infected cell cultures to combinations of the novel quinoxaline GW420867X with lamivudine, abacavir, and a variety of nonnucleoside reverse transcriptase inhibitors.
    AIDS research and human retroviruses, 2000, Apr-10, Volume: 16, Issue:6

    Topics: Alkynes; Anilides; Anti-HIV Agents; Benzoxazines; Cell Line; Cyclopropanes; Delavirdine; Dideoxynucleosides; Dose-Response Relationship, Drug; Drug Combinations; Drug Resistance, Microbial; Furans; HIV Reverse Transcriptase; HIV-1; Humans; Lamivudine; Microbial Sensitivity Tests; Mutation; Nevirapine; Oxazines; Quinoxalines; Reverse Transcriptase Inhibitors; Thioamides; Uracil

2000