Compounds > enzastaurin
Page last updated: 2024-09-05

enzastaurin and vx-745

enzastaurin has been researched along with vx-745 in 2 studies

Compound Research Comparison

Studies
(enzastaurin)		Trials
(enzastaurin)		Recent Studies (post-2010)
(enzastaurin)		Studies
(vx-745)		Trials
(vx-745)		Recent Studies (post-2010) (vx-745)
188529958135

Protein Interaction Comparison

ProteinTaxonomyenzastaurin (IC50)vx-745 (IC50)
Mitogen-activated protein kinase 13Homo sapiens (human)0.0577
Bile salt export pumpHomo sapiens (human)10
Tyrosine-protein kinase ABL1Homo sapiens (human)1
Cytochrome P450 3A4Homo sapiens (human)0.0008
Platelet-derived growth factor receptor betaHomo sapiens (human)1
Adenosine receptor A3Homo sapiens (human)8.547
Proto-oncogene tyrosine-protein kinase SrcHomo sapiens (human)1
Alpha-1B adrenergic receptorRattus norvegicus (Norway rat)8.547
Amine oxidase [flavin-containing] BRattus norvegicus (Norway rat)0.029
Mu-type opioid receptorRattus norvegicus (Norway rat)0.0008
Tyrosine-protein kinase ABL2Homo sapiens (human)1
Alpha-1A adrenergic receptorRattus norvegicus (Norway rat)8.547
Mitogen-activated protein kinase 14 Mus musculus (house mouse)0.0442
Mitogen-activated protein kinase 12Homo sapiens (human)0.0577
Sodium-dependent dopamine transporter Homo sapiens (human)8.098
Mitogen-activated protein kinase 11Homo sapiens (human)0.2462
Mitogen-activated protein kinase 14Homo sapiens (human)0.4028

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's2 (100.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Ciceri, P; Davis, MI; Herrgard, S; Hocker, M; Hunt, JP; Pallares, G; Treiber, DK; Wodicka, LM; Zarrinkar, PP1
Davis, MI; Khan, J; Li, SQ; Patel, PR; Shen, M; Sun, H; Thomas, CJ1

Other Studies

2 other study(ies) available for enzastaurin and vx-745

ArticleYear
Comprehensive analysis of kinase inhibitor selectivity.
    Nature biotechnology, 2011, Oct-30, Volume: 29, Issue:11

    Topics: Catalysis; Drug Design; Enzyme Stability; High-Throughput Screening Assays; Humans; Protein Binding; Protein Kinase Inhibitors; Protein Kinases; Proteomics; Signal Transduction; Substrate Specificity

2011
Identification of potent Yes1 kinase inhibitors using a library screening approach.
    Bioorganic & medicinal chemistry letters, 2013, Aug-01, Volume: 23, Issue:15

    Topics: Binding Sites; Cell Line; Cell Survival; Drug Design; Humans; Hydrogen Bonding; Molecular Docking Simulation; Protein Kinase Inhibitors; Protein Structure, Tertiary; Proto-Oncogene Proteins c-yes; Small Molecule Libraries; Structure-Activity Relationship

2013