yuehchukene: anti-implantation indole alkaloid from roots of Murraya paniculata; RN given refers to (6alpha,6aalpha,10aalpha)-(+-)-isomer; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| Flora | Rank | Flora Definition | Family | Family Definition |
|---|---|---|---|---|
| Murraya | genus | A plant genus of the family RUTACEAE. Members contain murrayanine, koenine, isomahanine, kwangsine, siamenol, murrayafoline A, murrayaquinone A and other cytotoxic carbazolequinones.[MeSH] | Rutaceae | A plant family in the order Sapindales that grows in warmer regions and has conspicuous flowers.[MeSH] |
| ID Source | ID |
|---|---|
| PubMed CID | 126009 |
| MeSH ID | M0136928 |
| Synonym |
|---|
| yuehchukene |
| brn 5300108 |
| indeno(2,1-b)indole, 5,6,6a,7,8,10a-hexahydro-6-(1h-indol-3-yl)-7,7,9-trimethyl-, (6-alpha,6a-alpha,10a-alpha)-(+-)- |
| 96624-37-2 |
| DTXSID80914414 |
| (+/-)-yuehchukene |
| Q8060261 |
Yuehchukene (YCK) is a novel bis-indole alkaloid with weak estrogenic activity.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Yuehchukene (YCK) is a novel bis-indole alkaloid with weak estrogenic activity. " | ( Yuehchukene, a bis-indole alkaloid, and cyclophosphamide are active in breast cancer in vitro. Cheng, G; Cheng, KF; Chui, CH; Ho, SK; Kong, YC; Lau, FY; Leung, TW; Poon, TC; Tang, JC; Tjong, JK; Tse, WC, ) | 3.02 |
| Excerpt | Relevance | Reference |
|---|---|---|
| "Oral or subcutaneous administration of yuehchukene to female mice at the dosage of 2 or 4 mg/kg." | ( [Studies on anti-implantation and hormone activity of yuehchukene, an alkaloid isolated from the root of Murraya paniculata]. Guan, MZ; Lei, HP; Wang, NG, 1990) | 0.8 |
| " From the dose-response curve, we discovered that 10(-2) M cyclophosphamide, even in its so-called 'bio-inert' form, could inhibit MCF-7 cell growth." | ( Yuehchukene, a bis-indole alkaloid, and cyclophosphamide are active in breast cancer in vitro. Cheng, G; Cheng, KF; Chui, CH; Ho, SK; Kong, YC; Lau, FY; Leung, TW; Poon, TC; Tang, JC; Tjong, JK; Tse, WC, ) | 1.57 |
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 3 (42.86) | 18.7374 |
| 1990's | 4 (57.14) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||