Compounds > tridiphane
Page last updated: 2024-12-06

tridiphane

Cross-References

ID SourceID
PubMed CID73669
CHEBI ID82251
SCHEMBL ID54378
MeSH IDM0146454

Synonyms (25)

Synonym
tridiphane
(.+/-.)-2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane
oxirane, 2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)-
epa pesticide chemical code 123901
nelpon
tridiphane [ansi:bsi:iso]
dowco 356
(rs)-2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane
2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane
58138-08-2
C19130
z5677lqe6j ,
unii-z5677lqe6j
SCHEMBL54378
tridiphane [iso]
tridiphane [mi]
CHEBI:82251
IBZHOAONZVJLOB-UHFFFAOYSA-N
2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)oxirane #
DTXSID8024365
oxirane, 2-(3,5-dichlorophenyl)-2-(2,2,2-trichloroethyl)-; dowco 356; nelpon; tridiphane
tridiphane 10 microg/ml in isooctane
Q22809031
EN300-11790710
Z2050021249

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" An increased percentage of females given 250 mg/kg/day showed implantation sites only after staining of the uterus, suggesting a toxic effect on the embryo during the early stages of development, possibly secondary to maternal toxicity."( Embryotoxicity and fetotoxicity of orally administered tridiphane in mice and rats.
Hanley, TR; Hayes, WC; John-Greene, JA; Rao, KS, 1987)		0.52

Pharmacokinetics

ExcerptReferenceRelevance
" The 14C plasma time-course exhibited a mono-exponential decrease with an absorption and elimination half-life of approximately 3 h and 11 h, respectively for both treatment groups."( Determination of the effect of tridiphane on the pharmacokinetics of [14C]-atrazine following oral administration to male Fischer 344 rats.
Dryzga, MD; Kastl, PE; Langvardt, PW; Osborne, DW; Timchalk, C, 1990)		0.57

Dosage Studied

ExcerptRelevanceReference
" Maternal toxicity was also observed among these mice as manifested by significantly elevated (+50%) liver weight; however, there was a substantial increase in the number of females with full-term litters following this shorter dosing period."( Embryotoxicity and fetotoxicity of orally administered tridiphane in mice and rats.
Hanley, TR; Hayes, WC; John-Greene, JA; Rao, KS, 1987)		0.52
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
dichlorobenzeneAny member of the class of chlorobenzenes carrying two chloro groups at unspecified positions.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 21.89

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index21.89 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (21.89)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
atrazine
[no description available]		6.9710chloro-1,3,5-triazine;
diamino-1,3,5-triazine		environmental contaminant;
herbicide;
xenobiotic
clofibrate
angiokapsul: contains clofibrate & insoitolnicotinate		1.9710aromatic ether;
ethyl ester;
monochlorobenzenes		anticholesteremic drug;
antilipemic drug;
geroprotector;
PPARalpha agonist
haloxyfop
haloxyfop: RN given refers to parent cpd. haloxyfop : A racemate comprising equimolar amounts of haloxyfop-P (the more active, R enantiomer) and (S)-haloxyfop (the less active enantiomer). A post-emergence herbicide used to control annual and perennial grass weeds. Commercial use of the racemate was phased out in favour of the most active enantiomer, used as the proherbicide esters haloxyfop-P-methyl and haloxyfop-P-etotyl.. 2-(4-{[3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoic acid : A monocarboxylic acid that is 2-phenoxypropanoic acid in which the hydrogen at the para position of the phenyl ring has been replaced by a [3-chloro-5-(trifluoromethyl)pyridin-2-yl]oxy group.		1.9810aromatic ether;
monocarboxylic acid;
organochlorine compound;
organofluorine compound;
pyridines
sulfur
Sulfur: An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.		1.9810chalcogen;
nonmetal atom		macronutrient
ConditionIndicatedRelationship StrengthStudiesTrials
Body Weight
The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.		02.3720
Fetal Death
Death of the developing young in utero. BIRTH of a dead FETUS is STILLBIRTH.		01.9710
Fetal Resorption
The disintegration and assimilation of the dead FETUS in the UTERUS at any stage after the completion of organogenesis which, in humans, is after the 9th week of GESTATION. It does not include embryo resorption (see EMBRYO LOSS).		01.9710
Abnormalities, Drug-Induced
Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.		01.9710
Pregnancy
The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.		01.9710
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