rabdocoetsin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rabdocoetsin B: Antineoplastic from Isodon coetsa [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Isodon	genus	A plant genus of the family LAMIACEAE used in TRADITIONAL CHINESE MEDICINE.[MeSH]	Lamiaceae	The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]
Isodon coetsa	species	[no description available]	Lamiaceae	The mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID Source	ID
PubMed CID	10452999
CHEMBL ID	460653
MeSH ID	M0557194

Synonyms (3)

Synonym
rabdocoetsin b
CHEMBL460653
[(1r,2s,5s,8r,9s,11r,15s,18r)-9,18-dihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay ID	Title	Year	Journal	Article
AID1067478	Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay	2014	ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2	Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337648	Cytotoxicity against human Lu1 cells after 3 days by SRB assay	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID1067455	Downregulation of CIP2A protein expression in human A549 cells after 24 hrs by Western blot analysis	2014	ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2	Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337651	Cytotoxicity against human KBVIN cells after 3 days by SRB assay	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID337650	Cytotoxicity against human KBVIN cells in presence of 1 ug/ml vinblastine after 3 days by SRB assay	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID1067456	Downregulation of CIP2A protein expression in human NCI-H1975 cells after 24 hrs by Western blot analysis	2014	ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2	Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID1067454	Downregulation of CIP2A mRNA expression in human A549 cells after 24 hrs by RT-PCR analysis	2014	ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2	Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337654	Cytotoxicity against human ASK cells after 3 days by SRB assay	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID1067479	Cytotoxicity against human NCI-H1975 cells assessed as growth inhibition after 48 hrs by MTT assay	2014	ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2	Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337655	Antimalarial activity against Plasmodium falciparum by [3H]hypoxanthine uptake	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID337649	Cytotoxicity against human KB cells after 3 days by SRB assay	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID337653	Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID337652	Cytotoxicity against human LNCAP cells after 3 days by SRB assay	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
AID337656	Inhibition of HIV1 reverse transcriptase	1994	Journal of natural products, Oct, Volume: 57, Issue:10	Cytotoxic diterpenoids from Isodon megathyrsus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	1 (20.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	13.13 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.92 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
ellipticine ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.	1.98	1	0	indole alkaloid; organic heterotetracyclic compound; organonitrogen heterocyclic compound; polycyclic heteroarene	antineoplastic agent; plant metabolite
colchicine (S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.	1.98	1	0	alkaloid; colchicine	anti-inflammatory agent; gout suppressant; mutagen

Condition	Relationship Strength	Studies
Esophageal Squamous Cell Carcinoma A carcinoma that originates usually from cells on the surface of the middle and lower third of the ESOPHAGUS. Tumor cells exhibit typical squamous morphology and form large polypoid lesions. Mutations in RNF6, LZTS1, TGFBR2, DEC1, and WWOX1 genes are associated with this cancer.	2.17	1
Cancer of Esophagus [description not available]	2.17	1
Esophageal Neoplasms Tumors or cancer of the ESOPHAGUS.	2.17	1
Chromosomal Translocation [description not available]	2.05	1
Acute Myelogenous Leukemia [description not available]	2.05	1
Leukemia, Myeloid, Acute Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.	2.05	1
Cancer of Lung [description not available]	2.06	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.06	1

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