Page last updated: 2024-11-12

rabdocoetsin b

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

rabdocoetsin B: Antineoplastic from Isodon coetsa [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
IsodongenusA plant genus of the family LAMIACEAE used in TRADITIONAL CHINESE MEDICINE.[MeSH]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]
Isodon coetsaspecies[no description available]LamiaceaeThe mint plant family. They are characteristically aromatic, and many of them are cultivated for their oils. Most have square stems, opposite leaves, and two-lipped, open-mouthed, tubular corollas (united petals), with five-lobed, bell-like calyxes (united sepals).[MeSH]

Cross-References

ID SourceID
PubMed CID10452999
CHEMBL ID460653
MeSH IDM0557194

Synonyms (3)

Synonym
rabdocoetsin b
CHEMBL460653
[(1r,2s,5s,8r,9s,11r,15s,18r)-9,18-dihydroxy-12,12-dimethyl-6-methylidene-7-oxo-17-oxapentacyclo[7.6.2.15,8.01,11.02,8]octadecan-15-yl] acetate
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1067478Cytotoxicity against human A549 cells assessed as growth inhibition after 48 hrs by MTT assay2014ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2
Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337648Cytotoxicity against human Lu1 cells after 3 days by SRB assay1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID1067455Downregulation of CIP2A protein expression in human A549 cells after 24 hrs by Western blot analysis2014ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2
Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337651Cytotoxicity against human KBVIN cells after 3 days by SRB assay1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID337650Cytotoxicity against human KBVIN cells in presence of 1 ug/ml vinblastine after 3 days by SRB assay1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID1067456Downregulation of CIP2A protein expression in human NCI-H1975 cells after 24 hrs by Western blot analysis2014ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2
Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID1067454Downregulation of CIP2A mRNA expression in human A549 cells after 24 hrs by RT-PCR analysis2014ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2
Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337654Cytotoxicity against human ASK cells after 3 days by SRB assay1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID1067479Cytotoxicity against human NCI-H1975 cells assessed as growth inhibition after 48 hrs by MTT assay2014ACS medicinal chemistry letters, Feb-13, Volume: 5, Issue:2
Ethoxysanguinarine Induces Inhibitory Effects and Downregulates CIP2A in Lung Cancer Cells.
AID337655Antimalarial activity against Plasmodium falciparum by [3H]hypoxanthine uptake1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID337649Cytotoxicity against human KB cells after 3 days by SRB assay1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID337653Cytotoxicity against human ZR-75-1 cells after 3 days by SRB assay1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID337652Cytotoxicity against human LNCAP cells after 3 days by SRB assay1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
AID337656Inhibition of HIV1 reverse transcriptase1994Journal of natural products, Oct, Volume: 57, Issue:10
Cytotoxic diterpenoids from Isodon megathyrsus.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's1 (20.00)18.2507
2000's1 (20.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 13.13

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index13.13 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.92 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (13.13)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]