Compounds > profluralin
Page last updated: 2024-12-06

profluralin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Profluralin is a dinitroaniline herbicide used to control annual grasses and broadleaf weeds in a variety of crops, including cotton, soybeans, peanuts, and corn. It is a selective herbicide, meaning that it is more toxic to weeds than to crop plants. Profluralin works by inhibiting the formation of microtubules, which are essential for cell division. This disrupts the growth and development of weeds. The synthesis of profluralin involves several steps, including the reaction of 2,6-dinitro-4-trifluoromethyl aniline with 1,3-dichloro-2-propanol. Profluralin has been studied extensively for its effects on plants, animals, and the environment. It is known to be toxic to fish and aquatic invertebrates, and it can accumulate in soil and water. However, its use is regulated in many countries to minimize environmental impacts. Profluralin is still studied because of its potential to provide effective weed control in agricultural systems. Researchers are investigating new formulations and application methods that could reduce the environmental risks associated with its use. Overall, profluralin is an important herbicide that provides significant benefits to agriculture, but its use must be carefully managed to minimize environmental risks.'

Cross-References

ID SourceID
PubMed CID33500
CHEMBL ID1256764
CHEBI ID82191
SCHEMBL ID54045
MeSH IDM0089669

Synonyms (56)

Synonym
benzenamine, n-(cyclopropylmethyl)-2,6-dinitro-n-propyl-4-(trifluoromethyl)-
p-toluidine, n-(cyclopropylmethyl)-.alpha.,.alpha.,.alpha.-trifluoro-2,6-dinitro-n-propyl-
profluralin
cga 10832
epa pesticide chemical code 106601
hsdb 3923
profluraline [iso-french]
n-cyclopropylmethyl-2,6-dinitro-n-propyl-4-trifluoromethylaniline
tolban
ga-10832
caswell no. 271bb
p-toluidine, n-(cyclopropylmethyl)-alpha,alpha,alpha-trifluoro-2,6-dinitro-n-propyl-
profluralin [ansi:bsi:iso]
b 4576
ai3-62694
pregard
n-cyclopropylmethyl-n-n-propyl-4-trifluoromethyl-2,6-dinitroaniline
sga 10832
brn 2179006
einecs 247-656-6
p-toluidine, n-(cyclopropylmethyl)-2,6-dinitro-n-propyl-alpha,alpha,alpha-trifluoro-
profluraline
n-(cyclopropylmethyl)-alpha,alpha,alpha-trifluoro-2,6-dinitro-n-propyl-p-toluidine
n-(cyclopropylmethyl)-2,6-dinitro-n-propyl-4-(trifluoromethyl)benzenamine
er5461
n-(cyclopropylmethyl)-2,6-dinitro-n-propyl-4-(trifluoromethyl)aniline
B-4576 ,
C19065
26399-36-0
dtxsid2044559 ,
tox21_301566
NCGC00255881-01
dtxcid0024559
cas-26399-36-0
CHEMBL1256764
chebi:82191 ,
unii-36w2l722ux
36w2l722ux ,
SCHEMBL54045
cga-10832
er-5461
sga-10832
n-cyclopropylmethyl-n-propyl-4-trifluoromethyl-2,6-dinitroaniline
n-cyclopropylmethyl-.alpha.,.alpha.,.alpha.-trifluoro-2,6-dinitro-n-propyl-p-toluidine
profluralin [hsdb]
cg-10832
profluralin [mi]
profluralin [iso]
er 5461
profluralin, pestanal(r), analytical standard
J-016410
n-cyclopropylmethyl-2,6-dinitro -n-propyl-4-(trifluoromethyl)benzenamine
Q15632821
HY-135466
CS-0113108
AKOS040744784

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" By assessing the type of bonding involved between pesticide and plants or soil, some assessment of the bioavailability of these bound residues to the environment can be made."( Incorporation of foreign compound metabolites into plant and soil constituents.
Adler, IR; Boka, G; Honeycutt, RC; Secrest, WL; Simoneaux, BJ; Sumner, DD, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
C-nitro compoundA nitro compound having the nitro group (-NO2) attached to a carbon atom.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (6)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency34.37620.001022.650876.6163AID1224839
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency58.57370.003041.611522,387.1992AID1159552; AID1159555
retinoid X nuclear receptor alphaHomo sapiens (human)Potency43.64120.000817.505159.3239AID1159531
pregnane X nuclear receptorHomo sapiens (human)Potency19.33120.005428.02631,258.9301AID1346982
thyroid stimulating hormone receptorHomo sapiens (human)Potency6.37100.001628.015177.1139AID1224843; AID1224895
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency68.58960.000323.4451159.6830AID743065; AID743067
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (13)

Assay IDTitleYearJournalArticle
AID522808Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin F24H mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522805Antimicrobial activity against Toxoplasma gondii RH infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522806Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin V4L mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522812Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235T mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522816Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243S mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522807Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin S6I mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522819Antimicrobial activity against Cryptosporidium parvum by short-term in vitro culture assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522815Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin R243C mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522810Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin L136F mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522814Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin T239I mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522813Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235V mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522811Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin I235L mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
AID522809Antimicrobial activity against Toxoplasma gondii RH containing alpha1-tubulin H28Q mutation infected in HFF cells by plaque assay2010Antimicrobial agents and chemotherapy, Apr, Volume: 54, Issue:4
Dinitroaniline activity in Toxoplasma gondii expressing wild-type or mutant alpha-tubulin.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (3)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (33.33)18.7374
1990's1 (33.33)18.2507
2000's0 (0.00)29.6817
2010's1 (33.33)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 20.04

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index20.04 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.36 (4.65)
Search Engine Demand Index15.26 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (20.04)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benefin
benefin: structure. benfluralin : A tertiany amino compound that is 2,6-dinitro-4-(trifluoromethyl)aniline in which the hydrogens attached to the aniline nitrogen have been replaced by one ethyl and one butyl group. It is used as a pre-emergence herbicide used for the control of grass and other weeds in a range of food and non-food crops.		2.0510C-nitro compound;
organofluorine compound;
substituted aniline;
tertiary amino compound		agrochemical;
herbicide
dapi
DAPI: RN given refers to parent cpd.		1.9910indolesfluorochrome
trifluralin
Trifluralin: A microtubule-disrupting pre-emergence herbicide.. trifluralin : A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.		7.6830(trifluoromethyl)benzenes;
C-nitro compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide;
xenobiotic
nitralin
nitralin: structure		2.0510C-nitro compound
oryzalin
oryzalin: a dinitroaniline; preemergence herbicide; structure. oryzalin : A sulfonamide that is benzenesulfonamide substituted at positions 3 and 5 by nitro groups and at position 4 by a dipropylamino group.		2.0510aromatic amine;
C-nitro compound;
sulfonamide;
tertiary amino compound		agrochemical;
antimitotic;
herbicide
dinitramine
dinitramine: structure		2.0510C-nitro compound
fluchloralin
fluchloralin: structure		2.4220C-nitro compound
butralin
butralin: structure		2.0510C-nitro compound
isopropalin
isopropalin: structure		2.0510C-nitro compound
pendimethalin
pendimethalin : A member of the class of substituted anilines that is N-(pentan-3-yl)aniline bearing two additional nitro substituents at positions 2 and 6 as well as two methyl substituents at positions 3 and 4. A herbicide used to control most annual grasses and many annual broad-leaved weeds.		2.0510C-nitro compound;
secondary amino compound;
substituted aniline		agrochemical;
environmental contaminant;
herbicide
ethafluralin
[no description available]		2.0510C-nitro compound
amiprophos methyl
amiprophos methyl: structure		2.0510
maduramicin
maduramicin: isolated from Actinomadura rubra		1.9910
n1-phenyl-3,5-dinitro-n4,n4-di-n-propylsulfanilamide
N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulfanilamide: a potent, selective antimitotic agent against kinetoplastid parasites; structure in first source		2.0510
ConditionIndicatedRelationship StrengthStudiesTrials