pipethiaden

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

pipethiaden: used in treatment of migraine; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	197209
CHEMBL ID	3634677
MeSH ID	M0131823

Synonyms (14)

Synonym
4m164i6e36 ,
pipethiadene
piperidine, 1-methyl-4-thieno(2,3-c)(2)benzothiepin-4(9h)-ylidene-
unii-4m164i6e36
1-methyl-4-thieno(2,3-c)(2)-benzothiepin-4(9h)-ylidene piperidine
15053-99-3
pipethiaden
1-methyl-4-(5h-thieno[2,3-c][2]benzothiepin-10-ylidene)piperidine
pipethiadene [who-dd]
piperidine, 1-methyl-4-(thieno(2,3-c)(2)benzothiepin-4(9h)-ylidene)-
CHEMBL3634677
DTXSID70164567
4-(1-methyl-4-piperidylidene)-4,9-dihydrothieno(2,3-c)-2-benzothiepin
Q27260070

Research Excerpts

Pharmacokinetics

Excerpt	Reference	Relevance
" Some pharmacokinetic parameters (e."	( Pharmacokinetics of 3H-pipethiaden after single oral and intravenous administration in rats. Franc, Z; Lapka, R; Smolik, S, 1985)	0.58

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (1)

Assay ID	Title	Year	Journal	Article
AID1256198	Inhibition of Legionella pneumophila recombinant PAH assessed as tyrosine production by DSF assay using 1 mM L-Phe as substrate and 200 uM BH4 as cofactor	2015	Journal of medicinal chemistry, Nov-12, Volume: 58, Issue:21	Discovery of a Specific Inhibitor of Pyomelanin Synthesis in Legionella pneumophila.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	5 (83.33)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (16.67)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.24

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.24 (24.57)
Research Supply Index	2.08 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.24)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	7 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
cyproheptadine Cyproheptadine: A serotonin antagonist and a histamine H1 blocker used as antipruritic, appetite stimulant, antiallergic, and for the post-gastrectomy dumping syndrome, etc.. cyproheptadine : The product resulting from the formal oxidative coupling of position 5 of 5H-dibenzo[a,d]cycloheptene with position 4 of 1-methylpiperidine resulting in the formation of a double bond between the two fragments. It is a sedating antihistamine with antimuscarinic and calcium-channel blocking actions. It is used (particularly as the hydrochloride sesquihydrate) for the relief of allergic conditions including rhinitis, conjunctivitis due to inhalant allergens and foods, urticaria and angioedema, and in pruritic skin disorders. Unlike other antihistamines, it is also a seratonin receptor antagonist, making it useful in conditions such as vascular headache and anorexia.	2.37	2	piperidines; tertiary amine	anti-allergic agent; antipruritic drug; gastrointestinal drug; H1-receptor antagonist; serotonergic antagonist
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	1.97	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
pizotyline Pizotyline: Serotonin antagonist used against MIGRAINE DISORDERS and vascular headaches.. pizotifen : A benzocycloheptathiophene that is 9,10-dihydro-4H-benzo[4,5]cyclohepta[1,2-b]thiophene 4-ylidene)-1-methylpiperidine which is joined from the 4 position to the 4 position of an N-methylpiperidine moiety by a double bond. It is a sedating antihistamine, with strong serotonin antagonist and weak antimuscarinic activity. It is generally used as the malate salt for the treatment of migraine and the prevention of headache attacks during cluster periods.	2.89	4	benzocycloheptathiophene	histamine antagonist; muscarinic antagonist; serotonergic antagonist
p-methoxy-n-methylphenethylamine p-Methoxy-N-methylphenethylamine: A potent mast cell degranulator. It is involved in histamine release.. N,O-dimethyltyramine : A secondary amino compound that is tyramine in which the hydrogen of the phenolic hydroxy group has been replaced by a methyl group.	1.97	1	aromatic ether; secondary amino compound	metabolite
piperidines Piperidines: A family of hexahydropyridines.	3.07	5

Condition	Relationship Strength	Studies
Infections, Legionella pneumophila [description not available]	2.11	1
Abdominal Migraine [description not available]	2.38	2
Migraine Disorders A class of disabling primary headache disorders, characterized by recurrent unilateral pulsatile headaches. The two major subtypes are common migraine (without aura) and classic migraine (with aura or neurological symptoms). (International Classification of Headache Disorders, 2nd ed. Cephalalgia 2004: suppl 1)	2.38	2
Anaphylactic Reaction [description not available]	1.97	1
Anaphylaxis An acute hypersensitivity reaction due to exposure to a previously encountered ANTIGEN. The reaction may include rapidly progressing URTICARIA, respiratory distress, vascular collapse, systemic SHOCK, and death.	1.97	1
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	1.97	1
Abnormalities, Autosome [description not available]	1.97	1
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	1.97	1

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