Compounds > ottelione a
Page last updated: 2024-11-12

ottelione a

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

ottelione A: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10946837
CHEMBL ID2204311
SCHEMBL ID10136107
MeSH IDM0443028

Synonyms (5)

Synonym
ottelione a
rac-ottelione a
CHEMBL2204311
SCHEMBL10136107
(1s,3s,3ar,7as)-1-ethenyl-3-[(3-hydroxy-4-methoxyphenyl)methyl]-7-methylidene-2,3,3a,7a-tetrahydro-1h-inden-4-one
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID712847Antiproliferative activity against human NCI-H460 cells assessed as cell viability after 72 hrs by CellTiter96 assay2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
AID712849Antiproliferative activity against human KB cells assessed as cell viability after 72 hrs by CellTiter96 assay2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
AID712844Antiproliferative activity against human COLO205 cells assessed as cell viability after 72 hrs by CellTiter96 assay2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
AID712848Antiproliferative activity against human MCF7 cells assessed as cell viability after 72 hrs by CellTiter96 assay2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
AID712842Inhibition of pig neuronal tubulin polymerization at 10 uM by fluorescence analysis2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
AID712846Antiproliferative activity against human HCT116 cells assessed as cell viability after 72 hrs by CellTiter96 assay2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
AID712845Antiproliferative activity against human A375 cells assessed as cell viability after 72 hrs by CellTiter96 assay2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
AID712843Displacement of [3H]colchicine from tubulin in pig brain at 10 uM after 16 hrs by scintillation proximity assay2012ACS medicinal chemistry letters, Dec-13, Volume: 3, Issue:12
Synthesis and antiproliferative activities of ottelione a analogues.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (11)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's6 (54.55)29.6817
2010's5 (45.45)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 11.91

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index11.91 (24.57)
Research Supply Index2.48 (2.92)
Research Growth Index4.39 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (11.91)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (9.09%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (90.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
colchicine
(S)-colchicine : A colchicine that has (S)-configuration. It is a secondary metabolite, has anti-inflammatory properties and is used to treat gout, crystal-induced joint inflammation, familial Mediterranean fever, and many other conditions.		2.0710alkaloid;
colchicine		anti-inflammatory agent;
gout suppressant;
mutagen
cyclopropane
cyclopropane : A cycloalkane composed of three carbon atoms to form a ring.		2.0410cycloalkane;
cyclopropanes		inhalation anaesthetic
cyclohexanol
Cyclohexanols: Monohydroxy derivatives of cyclohexanes that contain the general formula R-C6H11O. They have a camphorlike odor and are used in making soaps, insecticides, germicides, dry cleaning, and plasticizers.. cyclohexanols : An alcohol in which one or more hydroxy groups are attached to a cyclohexane skeleton.		2.0710cyclohexanols;
secondary alcohol		solvent
tiletamine hydrochloride
Cyclohexanones: Cyclohexane ring substituted by one or more ketones in any position.. cyclohexanones : Any alicyclic ketone based on a cyclohexane skeleton and its substituted derivatives thereof.		4.84100
ConditionIndicatedRelationship StrengthStudiesTrials
Carcinoma, Ehrlich Tumor
A transplantable, poorly differentiated malignant tumor which appeared originally as a spontaneous breast carcinoma in a mouse. It grows in both solid and ascitic forms.		02.0710