Page last updated: 2024-10-14

lucidone

Description

lucidone: a compound with antiinflammatory activity from fruits of Lindera erythrocarpa; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID11253859
CHEBI ID183569
SCHEMBL ID6846053
MeSH IDM0522458

Synonyms (13)

Synonym
lucidone
LMPK12120439
3-hydroxy-4-methoxy-2-[(e)-3-phenylprop-2-enoyl]cyclopenta-2,4-dien-1-one
CHEBI:183569
4-cyclopentene-1,3-dione, 2-(1-hydroxy-3-phenyl-2-propenylidene)-4-methoxy-, (z,e)-
19956-53-7
SCHEMBL6846053
AKOS032948482
FS-9524
(2z)-2-[(2e)-1-hydroxy-3-phenylprop-2-en-1-ylidene]-4-methoxycyclopent-4-ene-1,3-dione
4-cyclopentene-1,3-dione, 2-(-hydroxycinnamylidene)-4-methoxy- (8ci); (2z)-2-[(2e)-1-hydroxy-3-phenyl-2-propenylidene]-4-methoxy-4-cyclopentene-1,3-dione
4-cyclopentene-1,3-dione, 2-[(2e)-1-hydroxy-3-phenyl-2-propenylidene]-4-methoxy-, (2z)-
AKOS040744744

Treatment

ExcerptReference
"Lucidone pretreatment (0.5-10 μg/mL) markedly increased HaCaT cell viability and suppressed AAPH-induced reactive oxygen species (ROS) generation, lipid peroxidation, and DNA damage."( Lucidone protects human skin keratinocytes against free radical-induced oxidative damage and inflammation through the up-regulation of HO-1/Nrf2 antioxidant genes and down-regulation of NF-κB signaling pathway.
Chang, SH; Chen, SC; Chou, CW; Hseu, YC; Hung, PC; Kumar, KJ; Lo, HW; Shen, PC; Tsai, YC; Wang, HM; Wang, SY; Yang, HL, 2013
)

Dosage Studied

ExcerptReference
" Five-week-old male C57BL/6 mice fed a high fat diet (60% energy from fat) supplemented with lucidone at a dosage of 1250 mg/kg of diet for 12 weeks had reduced body and liver weight, reduced epididymal and perirenal adipose tissue, decreased food efficiency (percentage of weight gain divided by food intake), and lowered plasma cholesterol, triglyceride, glucose, and insulin levels."( Lucidone from Lindera erythrocarpa Makino fruits suppresses adipogenesis in 3T3-L1 cells and attenuates obesity and consequent metabolic disorders in high-fat diet C57BL/6 mice.
Hsieh, YH; Wang, SY, 2013
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
olefinic compoundAny organic molecular entity that contains at least one C=C bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (10)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (20.00)29.6817
2010's7 (70.00)24.3611
2020's1 (10.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other10 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]