Compounds > letrazuril
Page last updated: 2024-12-06

letrazuril

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Letrazuril is a synthetic anticoccidial drug used to treat coccidiosis in animals, particularly in poultry and cattle. It acts by inhibiting the growth and development of coccidia parasites, which are protozoa that cause intestinal infections and can lead to significant economic losses in livestock production. Letrazuril is effective against a wide range of coccidia species, including Eimeria spp. in poultry and cattle. Its mechanism of action involves interfering with the parasite's mitochondrial electron transport chain, leading to energy depletion and ultimately parasite death. Letrazuril is typically administered orally in feed or water, and it has a long duration of action, providing protection against coccidiosis for several weeks. The drug has been shown to be safe and effective in numerous studies, and it is widely used in the livestock industry. Letrazuril's effectiveness, safety, and wide spectrum of activity have made it a valuable tool for preventing and controlling coccidiosis in animals. It has contributed to improved animal health, reduced economic losses, and enhanced food production.'
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letrazuril: effective against Cryptosporidium infections [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID59745
CHEMBL ID2104819
SCHEMBL ID466345
MeSH IDM0215577

Synonyms (26)

Synonym
letrazuril [inn]
2-[2,6-dichloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]-2-(4-fluorophenyl)acetonitrile
[2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)phenyl](4-fluorophenyl)acetonitrile
CHEMBL2104819
(+-)-(2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-as-triazin-2(3h)-yl)phenyl)(p-fluorophenyl)acetonitrile
u8736vcb22 ,
letrazurilo [inn-spanish]
letrazurilum [inn-latin]
unii-u8736vcb22
letrazurilo
letrazuril
103337-74-2
letrazurilum
(+/-)-(2,6-dichloro-4-(4,5-dihydro-3,5-dioxo-as-triazin-2(3h)-yl)phenyl)(p-fluorophenyl)acetonitrile
letrazuril [mart.]
SCHEMBL466345
CS-7795
c17h9cl2fn4o2
HY-106859
DB12663
DTXSID60869392
2-(2,6-dichloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)phenyl)-2-(4-fluorophenyl)acetonitrile
W18799
Q27290829
AS-56245
AKOS037645026
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's6 (100.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (33.33%)5.53%
Reviews0 (0.00%)6.00%
Case Studies3 (50.00%)4.05%
Observational0 (0.00%)0.25%
Other1 (16.67%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
paromomycin
Paromomycin: An aminoglycoside antibacterial and antiprotozoal agent produced by species of STREPTOMYCES.. paromomycin : An amino cyclitol glycoside that is the 1-O-(2-amino-2-deoxy-alpha-D-glucopyranoside) and the 3-O-(2,6-diamino-2,6-dideoxy-beta-L-idopyranosyl)-beta-D-ribofuranoside of 4,6-diamino-2,3-dihydroxycyclohexane (the 1R,2R,3S,4R,6S diastereoisomer). It is obtained from various Streptomyces species. A broad-spectrum antibiotic, it is used (generally as the sulfate salt) for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoal infections. It is also used as a therapeutic against visceral leishmaniasis.		7.3920amino cyclitol glycoside;
aminoglycoside antibiotic		anthelminthic drug;
antibacterial drug;
antiparasitic agent;
antiprotozoal drug
zithromax
Azithromycin: A semi-synthetic macrolide antibiotic structurally related to ERYTHROMYCIN. It has been used in the treatment of Mycobacterium avium intracellulare infections, toxoplasmosis, and cryptosporidiosis.. azithromycin : A macrolide antibiotic useful for the treatment of bacterial infections.		1.9910macrolide antibioticantibacterial drug;
environmental contaminant;
xenobiotic
ConditionIndicatedRelationship StrengthStudiesTrials
Acquired Immune Deficiency Syndrome
[description not available]		05.5432
Cryptosporidium Infection
[description not available]		05.9452
Acquired Immunodeficiency Syndrome
An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993.		05.5432
Cryptosporidiosis
Intestinal infection with organisms of the genus CRYPTOSPORIDIUM. It occurs in both animals and humans. Symptoms include severe DIARRHEA.		05.9452
Diarrhea
An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.		08.7721
AIDS Seroconversion
[description not available]		04.2811
AIDS-Related Opportunistic Infections
Opportunistic infections found in patients who test positive for human immunodeficiency virus (HIV). The most common include PNEUMOCYSTIS PNEUMONIA, Kaposi's sarcoma, cryptosporidiosis, herpes simplex, toxoplasmosis, cryptococcosis, and infections with Mycobacterium avium complex, Microsporidium, and Cytomegalovirus.		05.241
Cholangiitis, Sclerosing
[description not available]		02.3920
Cholangitis, Sclerosing
Chronic inflammatory disease of the BILIARY TRACT. It is characterized by fibrosis and hardening of the intrahepatic and extrahepatic biliary ductal systems leading to bile duct strictures, CHOLESTASIS, and eventual BILIARY CIRRHOSIS.		02.3920
Intestinal Diseases, Parasitic
Infections of the INTESTINES with PARASITES, commonly involving PARASITIC WORMS. Infections with roundworms (NEMATODE INFECTIONS) and tapeworms (CESTODE INFECTIONS) are also known as HELMINTHIASIS.		01.9810