Page last updated: 2024-12-07
lc 6
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Market Indicators
Description
LC 6: RN given refers to (trans)-isomer; structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 106696 |
| CHEMBL ID | 3249770 |
| MeSH ID | M0067191 |
Synonyms (9)
| Synonym |
|---|
| lc 6 |
| (3bs,8br)-3,3b,4,5,8,8b,9,10-octahydroindazolo[7,6-g]indazole |
| 66818-22-2 |
| trans-2,3b,4,5,7,8b,9,10-octahydronaphtho(1,2-c:5,6-c')dipyrazole |
| lc-6 |
| naphtho(1,2-c:5,6-c')dipyrazole, 2,3b,4,5,7,8b,9,10-octahydro-, trans- |
| CHEMBL3249770 |
| (3br,8bs)-2,3b,4,5,7,8b,9,10-octahydroindazolo[7,6-g]indazole |
| AKOS040747024 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Bioassays (7)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1134815 | Antiallergic activity in Sprague-Dawley rat assessed as inhibition of mouse antiserum-induced passive cutaneous anaphylaxis at 25 mg/kg, po administered 1 hr before antiserum challenge measured after 30 mins by Evans blue staining relative to control | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound. |
| AID1134819 | Antiallergic activity in Sprague-Dawley rat assessed as inhibition of mouse antiserum-induced passive cutaneous anaphylaxis at 0.5 mg/kg, iv administered with antiserum measured after 30 mins by Evans blue staining relative to control | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound. |
| AID1134817 | Antiallergic activity in Sprague-Dawley rat assessed as inhibition of mouse antiserum-induced passive cutaneous anaphylaxis at 100 mg/kg, po administered 1 hr before antiserum challenge measured after 3 hrs by Evans blue staining relative to control | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound. |
| AID1134816 | Antiallergic activity in Sprague-Dawley rat assessed as inhibition of mouse antiserum-induced passive cutaneous anaphylaxis at 50 mg/kg, po administered 1 hr before antiserum challenge measured after 30 mins by Evans blue staining relative to control | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound. |
| AID1134820 | Antiallergic activity in po dosed Sprague-Dawley rat assessed as inhibition of mouse antiserum-induced passive cutaneous anaphylaxis administered 1 hr before antiserum challenge measured after 30 mins by Evans blue staining | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound. |
| AID1134821 | Antiallergic activity in Sprague-Dawley rat assessed as inhibition of mouse antiserum-induced passive cutaneous anaphylaxis at 5 to 6 times ED50 mg/kg, po administered 1 hr before antiserum challenge measured after 30 mins by Evans blue staining relative | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound. |
| AID1134818 | Antiallergic activity in Sprague-Dawley rat assessed as inhibition of mouse antiserum-induced passive cutaneous anaphylaxis at 200 mg/kg, po administered 1 hr before antiserum challenge measured after 6 hrs by Evans blue staining relative to control | 1978 | Journal of medicinal chemistry, Jul, Volume: 21, Issue:7 | trans-2,3b,4,5,7,8b,9,10-Octahydronaphtho[1,2-c:5,6-c']dipyrazole, a new orally active antiallergic compound. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (5)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 5 (100.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Market Indicators
Research Demand Index: 34.54
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.
| This Compound (34.54) All Compounds (24.57) |
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||