Page last updated: 2024-12-06

iosulamide

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

Iosulamide is a sulfonamide derivative that acts as a carbonic anhydrase inhibitor. Its synthesis involves a multi-step process, typically starting with the reaction of an aromatic amine with a sulfonyl chloride. Iosulamide exhibits diuretic properties and has been studied for its potential therapeutic applications in conditions such as glaucoma and epilepsy. Its mechanism of action involves blocking the enzyme carbonic anhydrase, which plays a role in fluid and electrolyte balance. Research on iosulamide has focused on understanding its pharmacological properties, potential clinical uses, and its interactions with other drugs.'

iosulamide: RN given refers to parent cpd; see also iosulamide meglumine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44557
CHEMBL ID1615440
SCHEMBL ID2109419
MeSH IDM0092610

Synonyms (18)

Synonym
iosulamide
3-[acetyl(ethyl)amino]-5-[3-[3-[3-[acetyl(ethyl)amino]-5-carboxy-2,4,6-triiodoanilino]-3-oxopropyl]sulfonylpropanoylamino]-2,4,6-triiodobenzoic acid
iosulamido
ip251kpi8e ,
einecs 245-487-2
iosulamido [inn-spanish]
23205-04-1
iosulamidum
unii-ip251kpi8e
iosulamide [usan:inn]
iosulamidum [inn-latin]
iosulamide [inn]
3,3'-(sulfonylbis(ethylenecarbonylimino))bis(5-(n-ethylacetamino)-2,4,6-triiodobenzoic acid)
benzoic acid, 3,3'-(sulfonylbis((1-oxo-3,1-propanediyl)imino))bis(5-(acetylethylamino)-2,4,6-triiodo-
SCHEMBL2109419
CHEMBL1615440
DTXSID00177786
Q27280833

Research Excerpts

Overview

Iosulamide is a bis-benzoic analogue of metrizoate. It shows clear advantages in animal tests over meglumine iodipamide.

ExcerptReferenceRelevance
"Iosulamide is a bis-benzoic analogue of metrizoate that shows clear advantages in animal tests over meglumine iodipamide. "( Iosulamide: a new intravenous cholangiocholecystographic medium.
Ackerman, JH; Nickel, AR; Rosenberg, FJ,
)
3.02

Pharmacokinetics

ExcerptReferenceRelevance
" The method was used to determine pharmacokinetic parameters of iosulamide after intravenous administration to rhesus monkeys."( Analysis of iosulamide in plasma and urine: application to intravenous pharmacokinetics in rhesus monkey.
Biddlecome, CE; Edelson, J; Kullberg, MP; Park, GB; Rowe, EA,
)
0.75
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (2)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]