Compounds > iosulamide
Page last updated: 2024-12-06

iosulamide

Description

Iosulamide is a sulfonamide derivative that acts as a carbonic anhydrase inhibitor. Its synthesis involves a multi-step process, typically starting with the reaction of an aromatic amine with a sulfonyl chloride. Iosulamide exhibits diuretic properties and has been studied for its potential therapeutic applications in conditions such as glaucoma and epilepsy. Its mechanism of action involves blocking the enzyme carbonic anhydrase, which plays a role in fluid and electrolyte balance. Research on iosulamide has focused on understanding its pharmacological properties, potential clinical uses, and its interactions with other drugs.'

iosulamide: RN given refers to parent cpd; see also iosulamide meglumine [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID44557
CHEMBL ID1615440
SCHEMBL ID2109419
MeSH IDM0092610

Synonyms (18)

Synonym
iosulamide
3-[acetyl(ethyl)amino]-5-[3-[3-[3-[acetyl(ethyl)amino]-5-carboxy-2,4,6-triiodoanilino]-3-oxopropyl]sulfonylpropanoylamino]-2,4,6-triiodobenzoic acid
iosulamido
ip251kpi8e ,
einecs 245-487-2
iosulamido [inn-spanish]
23205-04-1
iosulamidum
unii-ip251kpi8e
iosulamide [usan:inn]
iosulamidum [inn-latin]
iosulamide [inn]
3,3'-(sulfonylbis(ethylenecarbonylimino))bis(5-(n-ethylacetamino)-2,4,6-triiodobenzoic acid)
benzoic acid, 3,3'-(sulfonylbis((1-oxo-3,1-propanediyl)imino))bis(5-(acetylethylamino)-2,4,6-triiodo-
SCHEMBL2109419
CHEMBL1615440
DTXSID00177786
Q27280833

Research Excerpts

Overview

Iosulamide is a bis-benzoic analogue of metrizoate. It shows clear advantages in animal tests over meglumine iodipamide.

ExcerptReferenceRelevance
"Iosulamide is a bis-benzoic analogue of metrizoate that shows clear advantages in animal tests over meglumine iodipamide. "( Iosulamide: a new intravenous cholangiocholecystographic medium.
Ackerman, JH; Nickel, AR; Rosenberg, FJ, )		3.02

Pharmacokinetics

ExcerptReferenceRelevance
" The method was used to determine pharmacokinetic parameters of iosulamide after intravenous administration to rhesus monkeys."( Analysis of iosulamide in plasma and urine: application to intravenous pharmacokinetics in rhesus monkey.
Biddlecome, CE; Edelson, J; Kullberg, MP; Park, GB; Rowe, EA, )		0.75
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (2)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (50.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's1 (50.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
iodine
Iodine: A nonmetallic element of the halogen group that is represented by the atomic symbol I, atomic number 53, and atomic weight of 126.90. It is a nutritionally essential element, especially important in thyroid hormone synthesis. In solution, it has anti-infective properties and is used topically.. diiodine : Molecule comprising two covalently bonded iodine atoms with overall zero charge..		1.9610diatomic iodinenutrient
diatrizoic acid
Diatrizoate: A commonly used x-ray contrast medium. As DIATRIZOATE MEGLUMINE and as Diatrizoate sodium, it is used for gastrointestinal studies, angiography, and urography.. amidotrizoic acid : A member of the class of benzoic acids that is benzoic acid having iodo substituents at the 2-, 4- and 6-positions and acetamido substituents at the 3- and 5-positions. It is used, mainly as its N-methylglucamine and sodium salts, as an X-ray contrast medium in gastrointestinal studies, angiography, and urography.		2.4120acetamides;
benzoic acids;
organoiodine compound		environmental contaminant;
radioopaque medium;
xenobiotic
iodipamide
Iodipamide: A water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.. adipiodone : An organoiodine compound that is 3-amino-2,4,6-triiodobenzoic acid in which one of the amino hydrogens is substituted by a 6-(3-carboxy-2,4,6-triiodoanilino)-6-oxohexanoyl group. It is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography.		1.9610benzoic acids;
organoiodine compound;
secondary carboxamide		radioopaque medium
zinc oxide
Zinc Oxide: A mild astringent and topical protectant with some antiseptic action. It is also used in bandages, pastes, ointments, dental cements, and as a sunblock.		2.2110zinc molecular entity
isothiocyanic acid
[no description available]		2.2110hydracid;
one-carbon compound
ConditionIndicatedRelationship StrengthStudiesTrials
Acute Confusional Senile Dementia
[description not available]		02.2110
Alzheimer Disease
A degenerative disease of the BRAIN characterized by the insidious onset of DEMENTIA. Impairment of MEMORY, judgment, attention span, and problem solving skills are followed by severe APRAXIAS and a global loss of cognitive abilities. The condition primarily occurs after age 60, and is marked pathologically by severe cortical atrophy and the triad of SENILE PLAQUES; NEUROFIBRILLARY TANGLES; and NEUROPIL THREADS. (From Adams et al., Principles of Neurology, 6th ed, pp1049-57)		02.2110
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