Compounds > hypnophilin
Page last updated: 2024-11-12

hypnophilin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

hypnophilin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID10264031
CHEMBL ID506567
CHEBI ID181698
MeSH IDM0414390

Synonyms (14)

Synonym
(1s,3r,6r,7r,8r,11s)-6-hydroxy-5,5,8-trimethyl-9-methylidene-12-oxatetracyclo[6.4.0.01,11.03,7]dodecan-10-one
CHEBI:181698
80677-96-9
hypnophilin
inchi=1/c15h20o3/c1-7-10(16)12-15(18-12)6-8-5-13(2,3)11(17)9(8)14(7,15)4/h8-9,11-12,17h,1,5-6h2,2-4h3/t8-,9+,11-,12-,14+,15-/m1/s
CHEMBL506567
(-)-hypnophilin
KZ0A93H82W ,
cyclopenta(4,5)pentaleno(1,6a-b)oxiren-2(1ah)-one, octahydro-4-hydroxy-3a,5,5-trimethyl-3-methylene-, (1as-(1a.alpha.,3a.beta.,3b.alpha.,4.alpha.,6a.alpha.,7ar*))-
cyclopenta(4,5)pentaleno(1,6a-b)oxiren-2(1ah)-one, octahydro-4-hydroxy-3a,5,5-trimethyl-3-methylene-, (1as,3ar,3br,4r,6ar,7as)-
cyclopenta(4,5)pentaleno(1,6a-b)oxiren-2(1ah)-one, octahydro-4-hydroxy-3a,5,5-trimethyl-3-methylene-, (1as-(1aalpha,3abeta,3balpha,4alpha,6aalpha,7ar*))-
unii-kz0a93h82w
Q27282513
DTXSID301345614

Research Excerpts

Overview

Hypnophilin (HNP) is a sesquiterpene that is isolated from Lentinus.

ExcerptReferenceRelevance
"Hypnophilin (HNP) is a sesquiterpene that is isolated from Lentinus cf. "( The cytotoxic and proapoptotic activities of hypnophilin are associated with calcium signaling in UACC-62 cells.
Cota, BB; de Souza-Fagundes, EM; Leite, MF; Pinto, MC; Rodrigues, MA, 2013)		2.09
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sesquiterpenoidAny terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (9)

Assay IDTitleYearJournalArticle
AID399894Antimicrobial activity against Aspergillus niger2004Journal of natural products, Feb, Volume: 67, Issue:2
Biologically active compounds from Aphyllophorales (polypore) fungi.
AID399048Cytotoxicity against african green monkey Vero cells by SRB assay2005Journal of natural products, Nov, Volume: 68, Issue:11
Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.
AID399893Antimicrobial activity against Bacillus cereus2004Journal of natural products, Feb, Volume: 67, Issue:2
Biologically active compounds from Aphyllophorales (polypore) fungi.
AID399045Cytotoxicity against human KB cells by SRB assay2005Journal of natural products, Nov, Volume: 68, Issue:11
Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.
AID399046Cytotoxicity against human BC cells by SRB assay2005Journal of natural products, Nov, Volume: 68, Issue:11
Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.
AID399895Antimicrobial activity against Aspergillus flavus2004Journal of natural products, Feb, Volume: 67, Issue:2
Biologically active compounds from Aphyllophorales (polypore) fungi.
AID399047Cytotoxicity against human NCI-H187 cells by SRB assay2005Journal of natural products, Nov, Volume: 68, Issue:11
Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.
AID399044Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 after 42 hrs by [3H]hypoxanthine uptake2005Journal of natural products, Nov, Volume: 68, Issue:11
Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996.
AID399896Antimicrobial activity against Mucor rouxii2004Journal of natural products, Feb, Volume: 67, Issue:2
Biologically active compounds from Aphyllophorales (polypore) fungi.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (7)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (57.14)29.6817
2010's3 (42.86)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (28.57%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (71.43%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
ellipticine
ellipticine : A organic heterotetracyclic compound that is pyrido[4,3-b]carbazole carrying two methyl substituents at positions 5 and 11.		2.0210indole alkaloid;
organic heterotetracyclic compound;
organonitrogen heterocyclic compound;
polycyclic heteroarene		antineoplastic agent;
plant metabolite
egtazic acid
Egtazic Acid: A chelating agent relatively more specific for calcium and less toxic than EDETIC ACID.. ethylene glycol bis(2-aminoethyl)tetraacetic acid : A diether that is ethylene glycol in which the hydrogens of the hydroxy groups have been replaced by 2-[bis(carboxymethyl)amino]ethyl group respectively.		2.0810diether;
tertiary amino compound;
tetracarboxylic acid		chelator
cyclophellitol
cyclophellitol: structure given in first source; isolated from Phellinus sp.		3.1210
betulinan a
betulinan A: a lipid peroxidation inhibitor; from Lenzites betulina; structure given in first source		3.1210
coriolin
coriolin: sesquiterpene antibiotic isolated from Coriolus consors; structure in third source		7.0110
egonol
egonol : A member of the class of 1-benzofurans that is 1-benzofuran substituted by a methoxy group at position 7, a 1,3-benzodioxol-5-yl group at position 2 and a 3-hydroxypropyl group at position 5. It has been isolated from Styrax agrestis.		3.12101-benzofurans;
aromatic ether;
benzodioxoles;
primary alcohol		plant metabolite
sesquiterpenes
[no description available]		4.2350
1,2-bis(2-aminophenoxy)ethane n,n,n',n'-tetraacetic acid acetoxymethyl ester
[no description available]		2.0810
albaconol
albaconol: from the mushroom Albatrellus; structure in first source		3.1210
poricoic acid g
poricoic acid G: from Poria cocos (Polyporaceae); structure in first source. poricoic acid G : A tricyclic triterpenoid isolated from Poria cocos.		3.1210dicarboxylic acid;
secondary alcohol;
tricyclic triterpenoid		fungal metabolite
panepoxydone
panepoxydone: structure given in first source; RN refers to (1S-(1alpha,3(S*),5alpha,6alpha))-isomer		2.0510
artenimol
artenimol: derivative of antimalarial drug artemisinin (quinghaosu)		2.0210
hirsutene
hirsutene: structure in first source		3.1510
ConditionIndicatedRelationship StrengthStudiesTrials
Benign Neoplasms
[description not available]		02.0810
Neoplasms
New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.		02.0810