Page last updated: 2024-11-12
hypnophilin
Description
Research Excerpts
Clinical Trials
Roles
Classes
Pathways
Study Profile
Bioassays
Related Drugs
Related Conditions
Protein Interactions
Research Growth
Description
hypnophilin: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
Cross-References
| ID Source | ID |
|---|---|
| PubMed CID | 10264031 |
| CHEMBL ID | 506567 |
| CHEBI ID | 181698 |
| MeSH ID | M0414390 |
Synonyms (14)
| Synonym |
|---|
| (1s,3r,6r,7r,8r,11s)-6-hydroxy-5,5,8-trimethyl-9-methylidene-12-oxatetracyclo[6.4.0.01,11.03,7]dodecan-10-one |
| CHEBI:181698 |
| 80677-96-9 |
| hypnophilin |
| inchi=1/c15h20o3/c1-7-10(16)12-15(18-12)6-8-5-13(2,3)11(17)9(8)14(7,15)4/h8-9,11-12,17h,1,5-6h2,2-4h3/t8-,9+,11-,12-,14+,15-/m1/s |
| CHEMBL506567 |
| (-)-hypnophilin |
| KZ0A93H82W , |
| cyclopenta(4,5)pentaleno(1,6a-b)oxiren-2(1ah)-one, octahydro-4-hydroxy-3a,5,5-trimethyl-3-methylene-, (1as-(1a.alpha.,3a.beta.,3b.alpha.,4.alpha.,6a.alpha.,7ar*))- |
| cyclopenta(4,5)pentaleno(1,6a-b)oxiren-2(1ah)-one, octahydro-4-hydroxy-3a,5,5-trimethyl-3-methylene-, (1as,3ar,3br,4r,6ar,7as)- |
| cyclopenta(4,5)pentaleno(1,6a-b)oxiren-2(1ah)-one, octahydro-4-hydroxy-3a,5,5-trimethyl-3-methylene-, (1as-(1aalpha,3abeta,3balpha,4alpha,6aalpha,7ar*))- |
| unii-kz0a93h82w |
| Q27282513 |
| DTXSID301345614 |
Research Excerpts
Overview
Hypnophilin (HNP) is a sesquiterpene that is isolated from Lentinus.
| Excerpt | Reference | Relevance |
|---|---|---|
| "Hypnophilin (HNP) is a sesquiterpene that is isolated from Lentinus cf. " | ( The cytotoxic and proapoptotic activities of hypnophilin are associated with calcium signaling in UACC-62 cells. Cota, BB; de Souza-Fagundes, EM; Leite, MF; Pinto, MC; Rodrigues, MA, 2013) | 2.09 |
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
Drug Classes (1)
| Class | Description |
|---|---|
| sesquiterpenoid | Any terpenoid derived from a sesquiterpene. The term includes compounds in which the C15 skeleton of the parent sesquiterpene has been rearranged or modified by the removal of one or more skeletal atoms (generally methyl groups). |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
Bioassays (9)
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID399894 | Antimicrobial activity against Aspergillus niger | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2 | Biologically active compounds from Aphyllophorales (polypore) fungi. |
| AID399048 | Cytotoxicity against african green monkey Vero cells by SRB assay | 2005 | Journal of natural products, Nov, Volume: 68, Issue:11 | Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996. |
| AID399893 | Antimicrobial activity against Bacillus cereus | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2 | Biologically active compounds from Aphyllophorales (polypore) fungi. |
| AID399045 | Cytotoxicity against human KB cells by SRB assay | 2005 | Journal of natural products, Nov, Volume: 68, Issue:11 | Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996. |
| AID399046 | Cytotoxicity against human BC cells by SRB assay | 2005 | Journal of natural products, Nov, Volume: 68, Issue:11 | Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996. |
| AID399895 | Antimicrobial activity against Aspergillus flavus | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2 | Biologically active compounds from Aphyllophorales (polypore) fungi. |
| AID399047 | Cytotoxicity against human NCI-H187 cells by SRB assay | 2005 | Journal of natural products, Nov, Volume: 68, Issue:11 | Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996. |
| AID399044 | Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 after 42 hrs by [3H]hypoxanthine uptake | 2005 | Journal of natural products, Nov, Volume: 68, Issue:11 | Hirsutane sesquiterpenes from the fungus Lentinus connatus BCC 8996. |
| AID399896 | Antimicrobial activity against Mucor rouxii | 2004 | Journal of natural products, Feb, Volume: 67, Issue:2 | Biologically active compounds from Aphyllophorales (polypore) fungi. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
Research
Studies (7)
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (57.14) | 29.6817 |
| 2010's | 3 (42.86) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
Study Types
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 2 (28.57%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 5 (71.43%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||