globotetraose

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-D-Glcp : A linear amino tetrasaccharide consisting of D-glucose at the reducing end having an N-acetyl-beta-D-galactosaminyl-(1->3)-alpha-D-galactosyl-(1->4)-beta-D-galactosyl moiety attached at the 4-position. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	53477650
CHEBI ID	63013
MeSH ID	M0109855

Synonyms (12)

Synonym
(gal)2 (galnac)1 (glc)1
globotetraose
n-acetyl-beta-d-galactosaminyl-(1->3)-alpha-d-galactosyl-(1->4)-beta-d-galactosyl-(1->4)-d-glucose
beta-d-galpnac-(1->3)-alpha-d-galp-(1->4)-beta-d-galp-(1->4)-d-glcp
galnacbeta1-3galalpha1-4galbeta1-4glc
CHEBI:63013
galnacbeta1-3galalpha1-4galbeta1-4glc~oh
beta-d-galnac-(1->3)-alpha-d-gal-(1->4)-beta-d-gal-(1->4)-d-glc
2-acetamido-2-deoxy-beta-d-galactopyranosyl-(1->3)-alpha-d-galactopyranosyl-(1->4)-beta-d-galactopyranosyl-(1->4)-d-glucopyranose
W-203733
JMPCSGHAAIDYIN-WASRWFGHSA-N
Q27132335

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

Class	Description
amino tetrasaccharide	A tetrasaccharide derivative having one or more substituted or unsubstituted amino groups in place of hydroxy groups at unspecified positions.
galactosamine oligosaccharide
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (17)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	2 (11.76)	18.7374
1990's	5 (29.41)	18.2507
2000's	8 (47.06)	29.6817
2010's	2 (11.76)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (11.11%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	16 (88.89%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
uridine diphosphate n-acetylglucosamine Uridine Diphosphate N-Acetylglucosamine: Serves as the biological precursor of insect chitin, of muramic acid in bacterial cell walls, and of sialic acids in mammalian glycoproteins.	1.99	1
uridine diphosphate galactose Uridine Diphosphate Galactose: A nucleoside diphosphate sugar which can be epimerized into UDPglucose for entry into the mainstream of carbohydrate metabolism. Serves as a source of galactose in the synthesis of lipopolysaccharides, cerebrosides, and lactose.. UDP-alpha-D-galactose : A UDP-D-galactose in which the anomeric centre of the galactose moiety has alpha-configuration.	2.01	1	UDP-D-galactose	mouse metabolite
acetylgalactosamine Acetylgalactosamine: The N-acetyl derivative of galactosamine.	2.15	1	N-acetyl-D-hexosamine; N-acetylgalactosamine	Escherichia coli metabolite; human metabolite; mouse metabolite
cefoxitin Tn antigen: immediate precursor in biosynthesis of Thomsen-Friedenreich (T) antigen; present in about 90% of human carcinoma tissue; proposed as universal carcinoma marker. O-(N-acetyl-alpha-D-galactosaminyl)-L-serine : A non-proteinogenic L-amino acid that is N-acetyl-alpha-D-galactosamine linked via an alpha glycosidic bond to the O at position 3 of L-serine.	2.15	1	L-serine derivative; non-proteinogenic L-alpha-amino acid	tumour antigen
glycosides [no description available]	7.39	2
ammonium sulfate Ammonium Sulfate: Sulfuric acid diammonium salt. It is used in CHEMICAL FRACTIONATION of proteins.. ammonium sulfate : An inorganic sulfate salt obtained by reaction of sulfuric acid with two equivalents of ammonia. A high-melting (decomposes above 280degreeC) white solid which is very soluble in water (70.6 g/100 g water at 0degreeC; 103.8 g/100 g water at 100degreeC), it is widely used as a fertilizer for alkaline soils.	2.08	1	ammonium salt; inorganic sulfate salt	fertilizer
glycolipids [no description available]	2	1
globotriose alpha-D-Galp-(1->4)-alpha-D-Galp-(1->4)-beta-D-Glcp : A trisaccharide consisting of two alpha-D-galactose residues and a beta-D-glucose at the reducing end in a linear sequence and joined by (1->4) linkages.	8.82	3	trisaccharide

Condition	Relationship Strength	Studies
E coli Infections [description not available]	1.96	1
Escherichia coli Infections Infections with bacteria of the species ESCHERICHIA COLI.	1.96	1
Urinary Tract Infections Inflammatory responses of the epithelium of the URINARY TRACT to microbial invasions. They are often bacterial infections with associated BACTERIURIA and PYURIA.	1.96	1

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