tocotrienol, beta profile

beta-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5 and 8 and a farnesyl chain at position 2. It has been isolated from various cultivars of wheat. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID Source	ID
PubMed CID	5282348
CHEBI ID	33275
SCHEMBL ID	66599
SCHEMBL ID	16430159
MeSH ID	M0218843

Synonyms (49)

Synonym
BIDD:PXR0058
.epsilon.-tocopherol
(2r)-3,4-dihydro-2,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-2h-1-benzopyran-6-ol
CHEBI:33275
(2r)-2,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2h-chromen-6-ol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2r)-
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl]-, (2r)- (9ci)
3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyl-trideca-3,7,11-trienyl)-2h-1-benzopyran-6-ol
epsilon-tocopherol
beta-tocotrienol
d-beta-tocotrienol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, [r-(e,e)]-
490-23-3
6-chromanol,2,5,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)- (8ci)
tocotrienol, beta
2r,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl]-3,4-dihydro-2h-chromen-6-ol
LMPR02020055
(2r)-2,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
einecs 207-708-0
chh810zm8c ,
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-, (2r)-
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (2r)-
unii-chh810zm8c
[r-(e,e)]-3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-2h-1-benzopyran-6-ol
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2- ((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrien-1-yl)-, (2r)-
.beta.-tocotrienol
j37.066e ,
d-.beta.-tocotrienol
.epsilon.-tokoferol
beta-tocotrienol [who-dd]
.beta.-tocotrienol [mi]
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2- ((3e,7e)-4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (2r)-
2h-1-benzopyran-6-ol, 3,4-dihydro-2,5,8-trimethyl-2-(4,8,12-trimethyl-3,7,11-tridecatrienyl)-, (r-(e,e))-
SCHEMBL66599
tocotrienol, 5,8-dimethyl
a-tocotrienol
SCHEMBL16430159
beta-tocotrienol, analytical standard
Q171542
2,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyltrideca-3,7,11-trienyl]-3,4-dihydrochromen-6-ol
A934798
(2r)-2,5,8-trimethyl-2-[(3e,7e)-4,8,12-trimethyl-3,7,11-tridecatr ien-1-yl]-6-chromanol
MS-27089
DTXSID50883401
HY-108693
CS-0029986
d-beta- tocotrienol
beta -tocotrienol
AKOS040744870

Excerpt	Relevance	Reference
" The tocotrienol-rich fraction (TRF) of palm oil inhibited growth of MCF7 cells in both the presence and absence of estradiol with a nonlinear dose-response but such that complete suppression of growth was achieved at 8 microg/mL."	( Tocotrienols inhibit the growth of human breast cancer cells irrespective of estrogen receptor status. Darbre, P; Dils, R; Nesaretnam, K; Stephen, R, 1998)	0.3

Role	Description
plant metabolite	Any eukaryotic metabolite produced during a metabolic reaction in plants, the kingdom that include flowering plants, conifers and other gymnosperms.
antineoplastic agent	A substance that inhibits or prevents the proliferation of neoplasms.
apoptosis inducer	Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Class	Description
tocotrienol	A tocol in which the hydrocarbon chain at position 2 contains three double bonds.
vitamin E	Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathway	Proteins	Compounds
vitamin E biosynthesis (tocotrienols)	1	13

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (5.56)	18.7374
1990's	5 (27.78)	18.2507
2000's	4 (22.22)	29.6817
2010's	6 (33.33)	24.3611
2020's	2 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	19 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.03	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
2-methylpentane Hexanes: Six-carbon saturated hydrocarbon group of the methane series. Include isomers and derivatives. Various polyneuropathies are caused by hexane poisoning.	1.96	1	alkane
n-hexane hexane : An unbranched alkane containing six carbon atoms.	1.96	1	alkane; volatile organic compound	neurotoxin; non-polar solvent
potassium hydroxide potassium hydroxide: RN given refers to cpd with MF of K-OH	1.96	1	alkali metal hydroxide
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	5.67	18	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
tocopherols [no description available]	2.81	3
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid [no description available]	2.1	1	chromanol; monocarboxylic acid; phenols	antioxidant; ferroptosis inhibitor; neuroprotective agent; radical scavenger; Wnt signalling inhibitor
tyloxapol tyloxapol: non-ionic detergent with surface-active properties; incompatible with metals; surfactant also used in inhalation therapy; N1 is from CA Vol 90 Form Index; N1 in Chemline is same as synonym 8. tyloxapol : A polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions.	2.03	1
gamma-tocopherol gamma-Tocopherol: A natural tocopherol with less antioxidant activity than ALPHA-TOCOPHEROL. It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. As in BETA-TOCOPHEROL, it also has three methyl groups on the 6-chromanol nucleus but at different sites.. gamma-tocopherol : A tocopherol in which the chroman-6-ol core is substituted by methyl groups at positions 7 and 8. It is found particularly in maize (corn) oil and soya bean (soybean) oils.	2.47	2	tocopherol; vitamin E	algal metabolite; food antioxidant; plant metabolite
singlet oxygen Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.	2.1	1	chalcogen; monoatomic oxygen; nonmetal atom	macronutrient
tocotrienol, alpha alpha-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2, 5, 7 and 8 and a farnesyl chain at position 2. It has been found in palm oil derived from Elaeis guineensis.	5.26	12	tocotrienol; vitamin E	ferroptosis inhibitor; human metabolite; neuroprotective agent; plant metabolite
tocotrienol, delta delta-tocotrienol : A tocotrienol that is chroman-6-ol substituted by methyl groups at positions 2 and 8 and a farnesyl chain at position 2.	5.01	9	tocotrienol; vitamin E	anti-inflammatory agent; antineoplastic agent; apoptosis inducer; bone density conservation agent; NF-kappaB inhibitor; plant metabolite; radiation protective agent; Saccharomyces cerevisiae metabolite
plastochromanol 8 plastochromanol 8: has antiproliferative activity against 3T3-L1 cells and anti-adipogenic activity; structure; plastochromanol 3 is gamma-tocotrienol	4.88	13
beta-escin [no description available]	2	1
tocotrienols tocotrienol : A tocol in which the hydrocarbon chain at position 2 contains three double bonds.	5.34	13	diterpenoid
alpha-tocomonoenol alpha-tocomonoenol: isolated from the Pacific salmon, Oncorhynchus keta; structure in first source	2.15	1

Condition	Relationship Strength	Studies
Benign Neoplasms [description not available]	2.41	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.41	1
Breast Cancer [description not available]	4.1	3
Breast Neoplasms Tumors or cancer of the human BREAST.	4.1	3
Benign Neoplasms, Brain [description not available]	2.1	1
Cancer of Lung [description not available]	2.1	1
Brain Neoplasms Neoplasms of the intracranial components of the central nervous system, including the cerebral hemispheres, basal ganglia, hypothalamus, thalamus, brain stem, and cerebellum. Brain neoplasms are subdivided into primary (originating from brain tissue) and secondary (i.e., metastatic) forms. Primary neoplasms are subdivided into benign and malignant forms. In general, brain tumors may also be classified by age of onset, histologic type, or presenting location in the brain.	2.1	1
Lung Neoplasms Tumors or cancer of the LUNG.	2.1	1
Hormone-Dependent Neoplasms [description not available]	2.91	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2	1
Arteriosclerosis Thickening and loss of elasticity of the walls of ARTERIES of all sizes. There are many forms classified by the types of lesions and arteries involved, such as ATHEROSCLEROSIS with fatty lesions in the ARTERIAL INTIMA of medium and large muscular arteries.	2	1

tocotrienol, beta

Description

Cross-References

Synonyms (49)

Research Excerpts

Dosage Studied

Roles (3)

Drug Classes (2)

Pathways (1)

Research

Studies (18)

Market Indicators

Research Demand Index: 12.28

Study Types

tocotrienol, beta

Description

Cross-References

Synonyms (49)

Research Excerpts

Dosage Studied

Roles (3)

Drug Classes (2)

Pathways (1)

Research

Studies (18)

Market Indicators

Research Demand Index: 12.28

Study Types

Related Drugs (16)

Related Conditions (11)