Compounds > bis(2-propylheptyl)phthalate
Page last updated: 2024-12-07

bis(2-propylheptyl)phthalate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Bis(2-propylheptyl) phthalate (BPHP) is a phthalate ester commonly used as a plasticizer in a variety of materials, including PVC, polyvinyl chloride. Its synthesis involves the reaction of phthalic anhydride with 2-propyl-1-heptanol, a type of alcohol. BPHP, like other phthalates, has been studied for its potential endocrine disrupting effects, specifically its ability to interfere with the hormonal system. This concern arises due to its potential to mimic or block hormones, potentially causing health issues. Consequently, its presence in consumer products and its potential environmental impact have led to research efforts focusing on its toxicity, environmental fate, and bioaccumulation. The study of BPHP aims to understand its potential hazards to human health and the environment. While BPHP is generally considered less toxic than other phthalates like DEHP, research continues to assess its safety and potential environmental effects.'

bis(2-propylheptyl)phthalate: a plasticizer with endocrine disrupting activity; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID92344
SCHEMBL ID434343
MeSH IDM000602511

Synonyms (25)

Synonym
53306-54-0
1, bis(2-propylheptyl) ester
nsc-17071
bis-(2-propylheptyl) phthalate
nsc17071
bis(2-propylheptyl) phthalate
FT-0663385
bis(2-propylheptyl) benzene-1,2-dicarboxylate
einecs 258-469-4
1,2-benzenedicarboxylic acid, bis(2-propylheptyl) ester
ec 258-469-4
1,2-benzenedicarboxylic acid, 1,2-bis(2-propylheptyl) ester
nsc 17071
SCHEMBL434343
DTXSID5052173
AKOS028108536
di(2-propylheptyl) phthalate
di(2-propylheptyl)phthalate
di-(2-propylheptyl) phthalate
bis(2-propylheptyl)phthalate
phthalic acid, bis-2-propylheptyl ester
MTYUOIVEVPTXFX-UHFFFAOYSA-N
phthalic acid, bis-2-propylheptyl ester 100 microg/ml in acetonitrile
di-(2-propyl heptyl) phthalate
F71197

Research Excerpts

Bioavailability

ExcerptReferenceRelevance
" The absence of toxicity to reproduction of DPHP may be related to the comparatively low bioavailability of the parent compound and its metabolites."( Di-(2-propylheptyl) phthalate (DPHP) and its metabolites in blood of rats upon single oral administration of DPHP.
Filser, JG; Kessler, W; Klein, D; Lichtmannegger, J; Otter, R; Pütz, C; Semder, B, 2016)		0.43

Dosage Studied

ExcerptRelevanceReference
" A total of 28 signals show dose-response relationships and these signals contain a few isomers."( Exposure marker discovery of di-2(propylheptyl) phthalate using ultra-performance liquid chromatography-mass spectrometry and a rat model.
Chung, YN; Hsu, JY; Liao, PC; Shih, CL; Tien, CP; Zgoda, VG, 2019)		0.51
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (14)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (7.14)29.6817
2010's12 (85.71)24.3611
2020's1 (7.14)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.78

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.78 (24.57)
Research Supply Index2.71 (2.92)
Research Growth Index5.91 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.78)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews2 (14.29%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other12 (85.71%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
phthalic acid
phthalic acid: RN given refers to parent cpd; structure in Merck Index, 9th ed, #7178. phthalic acid : A benzenedicarboxylic acid cosisting of two carboxy groups at ortho positions.		2.1710benzenedicarboxylic acidhuman xenobiotic metabolite
camphor, (+-)-isomer
[no description available]		3.2510bornane monoterpenoid;
cyclic monoterpene ketone		plant metabolite
vinyl chloride
Vinyl Chloride: A gas that has been used as an aerosol propellant and is the starting material for polyvinyl resins. Toxicity studies have shown various adverse effects, particularly the occurrence of liver neoplasms.. chloroethene : A monohaloethene that is ethene in which one of the hydrogens has been replaced by a chloro group.		2.1710chloroethenes;
gas molecular entity;
monohaloethene		carcinogenic agent
terephthalic acid
terephthalic acid: RN given refers to 1,4-benzenedicarboxylic acid. terephthalic acid : A benzenedicarboxylic acid carrying carboxy groups at positions 1 and 4. One of three possible isomers of benzenedicarboxylic acid, the others being phthalic and isophthalic acids.		2.2110benzenedicarboxylic acid
4,4'-diphenylmethane diisocyanate
4,4'-diphenylmethane diisocyanate: used as a hardening agent incorporated in polyurethanes. diphenylmethane-4,4'-diisocyanate : A diisocyanate consisting of diphenylmethane with two isocyanate groups at the 4- and 4'-positions.		3.2510diisocyanateallergen;
hapten
n-heptane
Heptanes: Seven-carbon alkanes with the formula C7H16.. heptane : A straight-chain alkane with seven carbon atoms. It has been found in Jeffrey pine (Pinus jeffreyi).		2.1710alkane;
volatile organic compound		non-polar solvent;
plant metabolite
hexahydrophthalic acid
hexahydrophthalic acid: a major metabolite of hexahydrophthalic anhydride		2.2110
deuterium
Deuterium: The stable isotope of hydrogen. It has one neutron and one proton in the nucleus.		2.1710dihydrogen
dioctyl adipate
[no description available]		2.2110carboxylic ester
cyanates
Cyanates: Organic salts of cyanic acid containing the -OCN radical.. cyanates : Salts and esters of cyanic acid, HOC#N; compounds carrying the cyanate functional group -O-C#N.. isocyanates : Organonitrogen compounds that are derivatives of isocyanic acid; compounds containing the isocyanate functional group -N=C=O (as opposed to the cyanate group, -O-C#N).		3.2510
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		2.1710oxygen hydride;
oxygen radical;
reactive oxygen species
captax
captax: RN given refers to parent cpd. 1,3-benzothiazole-2-thiol : 1,3-Benzothiazole substituted at the 2-position with a sulfanyl group.		3.2510aryl thiol;
benzothiazoles		carcinogenic agent;
metabolite
enzacamene
enzacamene: structure in first source; 4-MBC for short;		3.2510
ConditionIndicatedRelationship StrengthStudiesTrials
Disease Models, Animal
Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.		02.2110
Sensitivity and Specificity
Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)		02.1110