actinidine

Description

Actinidine is a pyridinium alkaloid found in the leaves, stems, and roots of Actinidia species, particularly in kiwifruit (Actinidia deliciosa). It is a potent inhibitor of monoamine oxidase (MAO), an enzyme involved in the breakdown of neurotransmitters such as dopamine, norepinephrine, and serotonin. The synthesis of actinidine involves a complex series of enzymatic reactions, but the exact pathway is not fully understood. Research on actinidine focuses on its potential therapeutic applications, including its ability to enhance cognitive function, reduce oxidative stress, and modulate mood. Studies have shown that actinidine may have antidepressant-like effects and could be beneficial for treating Parkinson's disease and Alzheimer's disease. Additionally, actinidine has been investigated for its antimicrobial and anti-inflammatory properties. Its importance lies in its potential to contribute to the development of novel drugs and treatments for various neurological and other disorders.'

actinidine: found in VALERIAN and NEPETA; RN given refers to the (S)-(-)-isomer; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

actinidine : A member of the class of cyclopentapyridines that is 6,7-dihydrocyclopenta[c]pyridine bearing two methyl substituents at positions 4 and 7. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]