| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
debrisoquin
Debrisoquin: An adrenergic neuron-blocking drug similar in effects to GUANETHIDINE. It is also noteworthy in being a substrate for a polymorphic cytochrome P-450 enzyme. Persons with certain isoforms of this enzyme are unable to properly metabolize this and many other clinically important drugs. They are commonly referred to as having a debrisoquin 4-hydroxylase polymorphism. | 1.96 | 1 | 0 | carboxamidine;
isoquinolines | adrenergic agent;
antihypertensive agent;
human metabolite;
sympatholytic agent |
phenformin
Phenformin: A biguanide hypoglycemic agent with actions and uses similar to those of METFORMIN. Although it is generally considered to be associated with an unacceptably high incidence of lactic acidosis, often fatal, it is still available in some countries. (From Martindale, The Extra Pharmacopoeia, 30th ed, p290). phenformin : A member of the class of biguanides that is biguanide in which one of the terminal nitrogen atoms is substituted by a 2-phenylethyl group. It was used as an anti-diabetic drug but was later withdrawn from the market due to potential risk of lactic acidosis. | 8.35 | 7 | 0 | biguanides | antineoplastic agent;
geroprotector;
hypoglycemic agent |
4-hydroxydebrisoquin
4-hydroxydebrisoquin: principal metabolite of above; RN given refers to parent cpd. 4-hydroxydebrisoquin : An isoquinoline that is 3,4-dihydroisoquinoline bearing amidino and hydroxy substituent at positions 2 and 4 respectively. | 1.96 | 1 | 0 | carboxamidine;
isoquinolines;
secondary alcohol | metabolite |
5,6-didehydrosparteine
5-dehydrosparteine: urinary metabolite of sparteine; RN given refers to (7S-(7alpha,14alpha,14abeta))-isomer. 5,6-didehydrosparteine : A quinolizidine alkaloid obtained by formal dehydrogenation at the 5,6-position of sparteine. It is a metabolite of sparteine found in human urine and plasma. | 1.96 | 1 | 0 | organic heterotetracyclic compound;
quinolizidine alkaloid;
tertiary amino compound | human xenobiotic metabolite |
2-dehydrosparteine
2-dehydrosparteine: urinary metabolite of sparteine; RN given refers to (7S-(7alpha,7aalpha,14alpha,14beta))-isomer. 2,3-didehydrosparteine : A quinolizidine alkaloid obtained by formal dehydrogenation at the 2,3-position of sparteine. | 1.96 | 1 | 0 | quinolizidine alkaloid | |