Compounds > 4--demethylamino-4--hydroxystaurosporine

4--demethylamino-4--hydroxystaurosporine and staurosporine-aglycone

4--demethylamino-4--hydroxystaurosporine has been researched along with staurosporine-aglycone* in 1 studies

Other Studies

1 other study(ies) available for 4--demethylamino-4--hydroxystaurosporine and staurosporine-aglycone

Article	Year
A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity. The Journal of antibiotics, 1992, Volume: 45, Issue:2 A novel inhibitor of protein kinase C was found in the fermentation of a soil actinomycete, strain RK-1409. According to the taxonomic studies, the producing strain was designated as Streptomyces platensis subsp. malvinus RK-1409. The protein kinase C inhibitor, RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human chronic erythroleukemia cell, K-562, induced by phorbol 12,13-dibutyrate (PDBu) at the concentration of 10 ng/ml. The concentration of 3 ng/ml inhibited the activity of protein kinase C in vitro. RK-1409 inhibited the cell cycle progression at G2 phase of K-562 cells. Topics: Alkaloids; Carbazoles; G2 Phase; Indole Alkaloids; Protein Kinase C; Staurosporine; Streptomyces	1992

Article

Year

A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I. Taxonomy and biological activity.

The Journal of antibiotics, 1992, Volume: 45, Issue:2

A novel inhibitor of protein kinase C was found in the fermentation of a soil actinomycete, strain RK-1409. According to the taxonomic studies, the producing strain was designated as Streptomyces platensis subsp. malvinus RK-1409. The protein kinase C inhibitor, RK-1409 (7-oxostaurosporine) inhibited the morphological change of a human chronic erythroleukemia cell, K-562, induced by phorbol 12,13-dibutyrate (PDBu) at the concentration of 10 ng/ml. The concentration of 3 ng/ml inhibited the activity of protein kinase C in vitro. RK-1409 inhibited the cell cycle progression at G2 phase of K-562 cells.

Topics: Alkaloids; Carbazoles; G2 Phase; Indole Alkaloids; Protein Kinase C; Staurosporine; Streptomyces

1992