Compounds > 3-coumaranone
Page last updated: 2024-12-06

3-coumaranone

3-Coumaranone, also known as benzofuran-2(3H)-one, is a heterocyclic compound with a fused benzene and furan ring system. It has been studied for its potential biological activities. Some research focuses on its synthesis using various methods, such as the reaction of o-hydroxyacetophenone with formaldehyde. Other studies explore its effects on enzymes, particularly its ability to inhibit certain enzyme activities. The compound has also shown antifungal and antibacterial properties. Its importance lies in its potential as a building block for the synthesis of other bioactive molecules and its interesting pharmacological activities.'

Cross-References

ID SourceID
PubMed CID23556
CHEMBL ID2253270
SCHEMBL ID69412
MeSH IDM0590659

Synonyms (57)

Synonym
benzofuran-3-one
AC-20612
nsc-512726
3(2h)-benzofuranone
nsc512726
benzofuran-3(2h)-one
coumaran-3-one
coumaranone
7169-34-8
2h-3-benzofuranone
NCIOPEN2_003700
benzofuran-3(2h)-one, >=98.0% (hplc)
AKOS000223931
1-benzofuran-3-one
FT-0694917
A837290
1-benzofuran-3(2h)-one
2,3-dihydrobenzo[b]furan-3-one
2,3-dihydro-1-benzofuran-3-one
EN300-49168
3-coumaranone ,
kz7ls8k9lp ,
nsc 512726
ccris 3596
unii-kz7ls8k9lp
FT-0615540
PS-4359
AM20041072
AB02144
71699-34-8
SCHEMBL69412
3-(2h)-benzo[b]-furanone
benzofuran-3 (2h)-one
1-benzofuran-3-(2h)-one
benzofuran-3-(2h)-one
3-benzofuranone
1-benzofuran-3 (2h)-one
2h-benzofuran-3-one
2,3-dihydrobenzofuran-3-one
3-(2h)-benzo[b]furanone
CHEMBL2253270
mfcd00051810
SY011530
DTXSID20221917
2h-bezofuran-3-one
1-benzofuran-3(2h)-one #
STR06709
benzo[b]furan-3(2h)-one
AC-30814
CS-W001165
Z57101103
BCP07835
3-coumaranonebenzofuran-3(2h)-one
CCG-356035
C2825
PB43343
HY-W001165
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (2)

Assay IDTitleYearJournalArticle
AID1090556Antifeedant activity against Spodoptera litura in compound treated cork borer from fresh sweet potato leaves assessed as leaf disk consumed at 26.5 degC2007Journal of agricultural and food chemistry, Feb-07, Volume: 55, Issue:3
Synthesis and insect antifeedant activity of aurones against Spodoptera litura larvae.
AID1090554Antifeedant activity against Spodoptera litura in compound treated cork borer from fresh sweet potato leaves assessed as leaf disk consumed at 0.33 mg/cm2 at 26.5 degC2007Journal of agricultural and food chemistry, Feb-07, Volume: 55, Issue:3
Synthesis and insect antifeedant activity of aurones against Spodoptera litura larvae.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (20.00)29.6817
2010's4 (80.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 23.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index23.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index5.08 (4.65)
Search Engine Demand Index21.17 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (23.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
propadiene
[no description available]		2.1110allenes
rhodium
Rhodium: A hard and rare metal of the platinum group, atomic number 45, atomic weight 102.905, symbol Rh.. rhodium atom : A cobalt group element atom of atomic number 45.		2.1110cobalt group element atom
gold
Gold: A yellow metallic element with the atomic symbol Au, atomic number 79, and atomic weight 197. It is used in jewelry, goldplating of other metals, as currency, and in dental restoration. Many of its clinical applications, such as ANTIRHEUMATIC AGENTS, are in the form of its salts.		7.1110copper group element atom;
elemental gold
2-aminobenzaldehyde
2-aminobenzaldehyde: structure		7.1110
3',4'-dihydroxyaurone
3',4'-dihydroxyaurone : A hydroxyaurone that is aurone which is substituted by hydroxy groups at the 3' and 4' positions; major species at pH 7.3. It shows inhibitory activity against several isoforms of the histone deacetylase complex (HDAC).		2.0310catechols;
hydroxyaurone		EC 3.5.1.98 (histone deacetylase) inhibitor
aurone
[no description available]		2.0310aurones;
cyclic ketone
warfarin
Warfarin: An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.. warfarin : A racemate comprising equal amounts of (R)- and (S)-warfarin. Extensively used as both an anticoagulant drug and as a pesticide against rats and mice.. 4-hydroxy-3-(3-oxo-1-phenylbutyl)-1-benzopyran-2-one : A member of the class of coumarins that is 4-hydroxycoumarin which is substituted at position 3 by a 1-phenyl-3-oxo-1-butyl group.		3.0240benzenes;
hydroxycoumarin;
methyl ketone
ConditionIndicatedRelationship StrengthStudiesTrials
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