avenacoside b profile

avenacoside B: from Avena sativa L.; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

avenacoside B : A steroid saponin obtained from grain and leaves of oats (Avena sativa) that is nuatigenin in which the hydroxy group at position 26 is converted to its beta-D-glucoside and in which the hydroxy group at position 3 is converted into its methyl alpha-L-rhamnopyranosyl-(1->2)-[beta-D-glucopyranosyl-(1->3)-beta-D-glucopyranosyl-(1->4)]-beta-D-glucopyranoside derivative. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Related Flora

Flora	Rank	Flora Definition	Family	Family Definition
Avena	genus	Oats, genus of the family POACEAE.[MeSH]	Poaceae	A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.[MeSH]
Avena sativa	species	A plant species of the family POACEAE that is widely cultivated for its EDIBLE GRAIN.[MeSH]	Poaceae	A large family of narrow-leaved herbaceous grasses of the order Cyperales, subclass Commelinidae, class Liliopsida (monocotyledons). Food grains (EDIBLE GRAIN) come from members of this family. RHINITIS, ALLERGIC, SEASONAL can be induced by POLLEN of many of the grasses.[MeSH]

Cross-References

ID Source	ID
PubMed CID	71581002
CHEMBL ID	4635475
CHEBI ID	2938
MeSH ID	M0586711

Synonyms (8)

Synonym
nuatigenin 3-o-{alpha-l-rhamnopyranosyl-(1->2)-[beta-d-glucopyranosyl-(1->3)-beta-d-glucopyranosyl-(1->4)]-beta-d-glucopyranoside}-26-o-beta-d-glucopyranoside
C08888 ,
avenacoside b
(3beta,22s,25s)-3-{[6-deoxy-alpha-l-mannopyranosyl-(1->2)-[beta-d-glucopyranosyl-(1->3)-beta-d-glucopyranosyl-(1->4)]-beta-d-glucopyranosyl]oxy}-22,25-epoxyfurost-5-en-26-yl beta-d-glucopyranoside
CHEBI:2938
nuatigenin 3-o-{alpha-l-rhamnopyranosyl-(1->2)-[beta-d-glucopyranosyl-(1->3)-beta-d-glucopyranosyl-(1->4)]-beta-d-glucopyranoside} 26-o-beta-d-glucopyranoside
Q27105893
CHEMBL4635475

Roles (1)

Role	Description
metabolite	Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (5)

Class	Description
hexacyclic triterpenoid	A triterpenoid that consists of a hexacyclic ring system.
tetrasaccharide derivative	An oligosaccharide derivative that is formally obtained from a tetrasaccharide.
spiroketal	A cyclic ketal in which the ketal carbon is the only common atom of two rings.
steroid saponin	Any saponin derived from a hydroxysteroid.
beta-D-glucoside	Any D-glucoside in which the anomeric centre has beta-configuration.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (2)

Assay ID	Title	Year	Journal	Article
AID1663792	Cytotoxicity against mouse C2C12 cells assessed as reduction in cell viability at 0.3 to 10 uM by CCK8 assay	2020	Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14	Two new secondary metabolites isolated from Avena sativa L. (Oat) seedlings and their effects on osteoblast differentiation.
AID1663791	Induction of osteoblast differentiation in mouse C2C12 cells assessed as increase in ALP expression by ALP staining based assay	2020	Bioorganic & medicinal chemistry letters, 07-15, Volume: 30, Issue:14	Two new secondary metabolites isolated from Avena sativa L. (Oat) seedlings and their effects on osteoblast differentiation.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	5 (83.33)	24.3611
2020's	1 (16.67)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.56

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.56 (24.57)
Research Supply Index	1.95 (2.92)
Research Growth Index	4.51 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.56)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	2 (33.33%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	4 (66.67%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

avenacoside b

Description