Compounds > 6-bromo-2-naphthol
Page last updated: 2024-09-22

6-bromo-2-naphthol

Description

6-bromo-2-naphthol: RN given refers to cpd with specified bromide locant [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

6-bromo-2-naphthol : A member of the class of naphthols that is 2-naphthol carrying an additional bromo substituent at position 6. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID27144
CHEBI ID34466
SCHEMBL ID49667
MeSH IDM0106699

Synonyms (63)

Synonym
BIDD:ER0052
AC-12234
BB 0220620
bromo-6 naphtol-2 [french]
einecs 239-279-0
ai3-18464
2-naphthol, 6-bromo-
nsc 17563
2-naphthalenol, 6-bromo-
nsc17563
15231-91-1
nsc-17563
6-bromo-.beta.-naphthol
inchi=1/c10h7bro/c11-9-3-1-8-6-10(12)4-2-7(8)5-9/h1-6,12
6-bromo-2-naphthol
6-bromo-2-naphthol, 97%
B0621
HMS1651O22
6-bromonaphthalen-2-ol
AKOS000120485
6-bromo-naphthalen-2-ol
bromo-6 naphtol-2
87f10ahz3o ,
unii-87f10ahz3o
FT-0601033
AM20060520
F0701-0028
6-bromo2-hydroxynaphthalene
SCHEMBL49667
B-8922
2-hydroxy-6-bromonaphthalene
6-hydroxy-2-bromonaphthalene
2-bromo-6-hydroxynaphthalene
6-bromo-2-naphthalinol
6-bromo-beta-naphthol
CHEBI:34466
TS-00535
2-bromo-6-hydroxy-naphthalene
2-bromo-6-naphthol
6-bromo2-naphthol
6-bromo-2-napthol
6-bromo-naphthalene-2-ol
6-bromonaphth-2-ol
6-bromonapthalen-2-ol
6-bromo-2-hydroxynaphthalene
6-bromonaphthalene-2-ol
6bromo-2-naphthol
6-bromo-2-naphthalenol
6-bromo- 2hydroxynaphthalene
2-hydroxy-6-bromo-naphthalene
6-bromo-2-naphtol
W-201358
STR02406
mfcd00004081
DTXSID5074551
STL451630
CS-W001952
SY006200
(e)-hydrazinecarbohydrazonamide hydrochloride
Q27116088
EN300-17905
A851722
Z57074412

Drug Classes (2)

ClassDescription
naphtholsAny hydroxynaphthalene derivative that has a single hydroxy substituent.
organobromine compoundA compound containing at least one carbon-bromine bond.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Bioassays (5)

Assay IDTitleYearJournalArticle
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).2014Journal of biomolecular screening, Jul, Volume: 19, Issue:6
A High-Throughput Assay to Identify Inhibitors of the Apicoplast DNA Polymerase from Plasmodium falciparum.
AID1794808Fluorescence-based screening to identify small molecule inhibitors of Plasmodium falciparum apicoplast DNA polymerase (Pf-apPOL).
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (9)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's2 (22.22)29.6817
2010's4 (44.44)24.3611
2020's2 (22.22)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other9 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
2-naphthol[no description available]medium40naphtholantinematodal drug;
genotoxin;
human urinary metabolite;
human xenobiotic metabolite;
mouse metabolite;
radical scavenger
fast blue b[no description available]medium10aromatic diazonium ionhistological dye
glucose, (beta-d)-isomer[no description available]medium10D-glucopyranoseepitope;
mouse metabolite
acebutolol[no description available]medium10alpha-D-glucosyl-(1->4)-D-mannopyranose
glycosides[no description available]medium10
sodium dodecyl sulfate[no description available]medium10organic sodium saltdetergent;
protein denaturant
vitamin k5[no description available]low00naphthols
1-hydroxy-2-naphthoic acid[no description available]low00hydroxy monocarboxylic acid;
naphthoic acid;
naphthols		bacterial xenobiotic metabolite;
fungal xenobiotic metabolite
7-amino-4-hydroxy-2-naphthalenesulfonic acid[no description available]low00aminonaphthalenesulfonic acid;
naphthols		metabolite
1-nitroso-2-naphthol[no description available]low00naphthols
naphthol yellow[no description available]low00C-nitro compound;
naphthalenesulfonic acid;
naphthols		histological dye
(s)-binol[no description available]low00naphthols
2-hydroxy-1-naphthaldehyde[no description available]low00naphthaldehydes;
naphthols
scarlet red[no description available]low00azobenzenes;
bis(azo) compound;
naphthols		carcinogenic agent;
fluorochrome;
histological dye
sudan iii[no description available]low00azobenzenes;
bis(azo) compound;
naphthols		carcinogenic agent;
fluorochrome;
histological dye
aminaftone[no description available]low00naphthols
4-hydroxypropranolol[no description available]low00naphthols
2,6-dihydroxynaphthalene[no description available]low00naphthols
allenolic acid[no description available]low00naphthols
nepodin[no description available]low00naphthols
ponceau mx[no description available]low00azobenzenes;
naphthalenesulfonic acid;
naphthols		carcinogenic agent;
cardiotoxic agent
dihydrobunolol[no description available]low00naphthols
lasofoxifene[no description available]low00aromatic ether;
N-alkylpyrrolidine;
naphthols;
tetralins		antineoplastic agent;
bone density conservation agent;
cardioprotective agent;
estrogen receptor agonist;
estrogen receptor antagonist
dioncophylline c[no description available]low00aromatic ether;
biaryl;
isoquinoline alkaloid;
isoquinolines;
methoxynaphthalene;
methylnaphthalenes;
naphthols		antimalarial;
antiplasmodial drug;
metabolite
IPA-3[no description available]low00naphthols;
organic disulfide		EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
2-[2-hydroxy-6,7-dimethoxy-4-(4-morpholinyl)-1-naphthalenyl]-N-phenylacetamide[no description available]low00naphthols
1-[[(1-methyl-2-benzimidazolyl)amino]methyl]-2-naphthalenol[no description available]low00naphthols
N-[[(5-hydroxy-1-naphthalenyl)amino]-sulfanylidenemethyl]-2-furancarboxamide[no description available]low00naphthols
sirtinol[no description available]low00aldimine;
benzamides;
naphthols		anti-inflammatory agent;
EC 3.5.1.98 (histone deacetylase) inhibitor;
Sir2 inhibitor
N-[(2-hydroxy-1-naphthalenyl)-(4-methoxyphenyl)methyl]-2-methylpropanamide[no description available]low00naphthols
N-[(2-chlorophenyl)-(2-hydroxy-1-naphthalenyl)methyl]butanamide[no description available]low00naphthols
N-[(2-hydroxy-1-naphthalenyl)-(4-methylphenyl)methyl]cyclohexanecarboxamide[no description available]low00naphthols
n'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthahydrazide[no description available]low00catechols;
hydrazide;
hydrazone;
naphthols		EC 3.6.5.5 (dynamin GTPase) inhibitor
bromhexine[no description available]low00organobromine compound;
substituted aniline;
tertiary amino compound		mucolytic
bromodiphenhydramine[no description available]low00organobromine compound;
tertiary amino compound		antimicrobial agent;
H1-receptor antagonist;
muscarinic antagonist
bromisovalum[no description available]low00N-acylurea;
organobromine compound
liquid crystal polymer[no description available]low00conazole fungicide;
dichlorobenzene;
organobromine compound;
oxolanes;
triazole fungicide;
triazoles		antifungal agrochemical;
EC 1.14.13.70 (sterol 14alpha-demethylase) inhibitor
halothane[no description available]low00haloalkane;
organobromine compound;
organochlorine compound;
organofluorine compound		inhalation anaesthetic
nsc 664704[no description available]low00indolobenzazepine;
lactam;
organobromine compound		cardioprotective agent;
EC 2.7.11.22 (cyclin-dependent kinase) inhibitor;
EC 2.7.11.26 (tau-protein kinase) inhibitor;
geroprotector
naled[no description available]low00dialkyl phosphate;
organobromine compound;
organochlorine compound;
organophosphate insecticide		acaricide;
agrochemical;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
pipobroman[no description available]low00N-acylpiperazine;
organobromine compound;
tertiary carboxamide		alkylating agent;
antineoplastic agent
sulfobromophthalein[no description available]low002-benzofurans;
organobromine compound;
organosulfonic acid;
phenols		dye
tribromoethanol[no description available]low00alcohol;
organobromine compound
bromthymol blue[no description available]low002,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
polyphenol;
sultone		acid-base indicator;
dye;
two-colour indicator
brompheniramine[no description available]low00organobromine compound;
pyridines		anti-allergic agent;
H1-receptor antagonist
4-bromophenyl phenyl ether[no description available]low00aromatic ether;
organobromine compound
1-bromo-2-chloroethane[no description available]low00haloalkane;
organobromine compound;
organochlorine compound		mutagen
bromphenol blue[no description available]low002,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
phenols;
sultone		acid-base indicator;
dye;
two-colour indicator
bromcresol purple[no description available]low002,1-benzoxathiole;
arenesulfonate ester;
organobromine compound;
polyphenol;
sultone		acid-base indicator;
dye;
two-colour indicator
bromacil[no description available]low00organobromine compound;
pyrimidone
bromochlorodifluoromethane[no description available]low00one-carbon compound;
organobromine compound;
organochlorine compound;
organofluorine compound
perflubron[no description available]low00haloalkane;
organobromine compound;
perfluorinated compound		blood substitute;
radioopaque medium
eosine yellowish-(ys)[no description available]low00organic sodium salt;
organobromine compound		fluorochrome;
histological dye
1-bromo-2,4-dinitrobenzene[no description available]low00C-nitro compound;
organobromine compound
4-bromo-2-chlorophenol[no description available]low00halophenol;
monochlorobenzenes;
organobromine compound
cincreasin[no description available]low00benzoxazole;
organobromine compound
8-bromo cyclic adenosine monophosphate[no description available]low003',5'-cyclic purine nucleotide;
adenyl ribonucleotide;
organobromine compound		antidepressant;
protein kinase agonist
2,3,7,8-tetrabromodibenzo-4-dioxin[no description available]low00dibenzodioxine;
organobromine compound
decamethrin[no description available]low00aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organobromine compound		agrochemical;
antifeedant;
calcium channel agonist;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
pyrethroid ester insecticide
bromfenac[no description available]low00aromatic amino acid;
benzophenones;
organobromine compound;
substituted aniline		non-narcotic analgesic;
non-steroidal anti-inflammatory drug
1,2-dibromo-2,4-dicyanobutane[no description available]low00aliphatic nitrile;
organobromine compound		allergen;
sensitiser
5-bromo-4-chloro-3-indolyl beta-galactoside[no description available]low00beta-D-galactoside;
D-aldohexose derivative;
indolyl carbohydrate;
organobromine compound;
organochlorine compound		chromogenic compound
5-bromo-4-chloro-3-indoxyl phosphate[no description available]low00aryl phosphate;
indoles;
organobromine compound;
organochlorine compound		chromogenic compound
bromosuccinimide[no description available]low00dicarboximide;
organobromine compound;
pyrrolidinone		reagent
bromopyruvate[no description available]low002-oxo monocarboxylic acid;
organobromine compound;
oxo carboxylic acid		alkylating agent;
antineoplastic agent
gr 117289[no description available]low001-benzofurans;
biaryl;
imidazolyl carboxylic acid;
monocarboxylic acid;
organobromine compound;
organochlorine compound;
tetrazoles		angiotensin receptor antagonist;
antihypertensive agent
6-bromo-2-naphthyl-beta-galactopyranoside[no description available]low00beta-D-galactoside;
organobromine compound		chromogenic compound
2,2',4,4'-tetrabromodiphenyl ether[no description available]low00aromatic ether;
organobromine compound
bromoacetaldehyde[no description available]low00organobromine compound
monobromobimane[no description available]low00organobromine compound;
pyrazolopyrazole		fluorochrome
dibromobimane[no description available]low00organobromine compound;
pyrazolopyrazole		fluorochrome
6-bromo-3-(bromomethyl)-7-methyl-2,3,7-trichloro-1-octene[no description available]low00monoterpenoid;
organobromine compound;
organochlorine compound		algal metabolite;
antineoplastic agent;
marine metabolite
2,2',4,4',5,5'-hexabrominated diphenyl ether[no description available]low00aromatic ether;
organobromine compound
eosine-5-isothiocyanate[no description available]low00isothiocyanate;
organobromine compound
4-bromo-2-(4-chlorophenyl)-5-(trifluoromethyl)-1h-pyrrole-3-carbonitrile[no description available]low00monochlorobenzenes;
nitrile;
organobromine compound;
organochlorine acaricide;
organochlorine insecticide;
organofluorine acaricide;
organofluorine insecticide;
pyrroles		acaricide;
antifouling biocide;
insecticide
etravirine[no description available]low00aminopyrimidine;
aromatic ether;
dinitrile;
organobromine compound		antiviral agent;
HIV-1 reverse transcriptase inhibitor
2-(4-bromophenyl)-5-(2-methylphenyl)-1,3,4-oxadiazole[no description available]low00organobromine compound
mitobronitol[no description available]low00alcohol;
organobromine compound
pyrabactin[no description available]low00naphthalenes;
organobromine compound;
pyridines;
sulfonamide		abscisic acid receptor agonist;
hormone;
plant growth regulator
2-amino-4-[(4-bromophenyl)methylthio]-3-azaspiro[5.5]undeca-1,4-diene-1,5-dicarbonitrile[no description available]low00organobromine compound
SMER 28[no description available]low00organobromine compound;
quinazolines;
secondary amino compound		autophagy inducer
2-(4-bromophenyl)-3,5-dimethyl-4-oxido-6-phenylpyrazin-1-ium 1-oxide[no description available]low00organobromine compound
2-(4-bromophenyl)thiazolidine[no description available]low00organobromine compound
wiskostatin[no description available]low00carbazoles;
organobromine compound;
secondary alcohol;
tertiary amino compound
N-[1-(4-bromophenyl)ethyl]cyclobutanecarboxamide[no description available]low00organobromine compound
zd 6474[no description available]low00aromatic ether;
organobromine compound;
organofluorine compound;
piperidines;
quinazolines;
secondary amine		antineoplastic agent;
tyrosine kinase inhibitor
bromohydrin pyrophosphate[no description available]low00alkyl diphosphate;
organobromine compound		phosphoantigen
mitolactol[no description available]low00alcohol;
organobromine compound
bedaquiline[no description available]low00aromatic ether;
naphthalenes;
organobromine compound;
quinolines;
tertiary alcohol;
tertiary amino compound		antitubercular agent;
ATP synthase inhibitor
metrafenone[no description available]low00aromatic ether;
aryl phenyl ketone fungicide;
benzophenones;
organobromine compound		antifungal agrochemical
1-azakenpaullone[no description available]low00lactam;
organic heterotetracyclic compound;
organobromine compound;
organonitrogen heterocyclic compound		EC 2.7.11.26 (tau-protein kinase) inhibitor;
Wnt signalling activator
lonafarnib[no description available]low00benzocycloheptapyridine;
heteroarylpiperidine;
N-acylpiperidine;
organobromine compound;
organochlorine compound;
ureas
5-bromouridine triphosphate[no description available]low00organobromine compound;
pyrimidine ribonucleoside 5'-triphosphate
2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoic acid[no description available]low00biphenyls;
organobromine compound
ageladine a[no description available]low00alkaloid;
aromatic amine;
imidazopyridine;
organobromine compound;
pyrroles		angiogenesis inhibitor;
antineoplastic agent;
matrix metalloproteinase inhibitor;
metabolite
jaspamide b[no description available]low00cyclodepsipeptide;
organobromine compound		animal metabolite;
antineoplastic agent;
marine metabolite
massadine[no description available]low00alkaloid;
guanidines;
organobromine compound;
pyrrolecarboxamide		animal metabolite;
EC 2.5.1.59 (protein geranylgeranyltransferase type I) inhibitor;
marine metabolite
chlorantranilipole[no description available]low00monochlorobenzenes;
organobromine compound;
pyrazole insecticide;
pyrazoles;
pyridines;
secondary carboxamide		ryanodine receptor agonist
laurinterol[no description available]low00organobromine compound;
phenols;
sesquiterpenoid		antibacterial agent;
apoptosis inducer;
EC 3.6.3.9 (Na(+)/K(+)-transporting ATPase) inhibitor;
metabolite
ceratamine a[no description available]low00alkaloid;
aromatic ether;
cyclic ketone;
organic heterobicyclic compound;
organobromine compound;
secondary amino compound;
tertiary amine		antimitotic;
metabolite
cyantraniliprole[no description available]low00nitrile;
organobromine compound;
organochlorine compound;
pyrazole insecticide;
pyridines;
secondary carboxamide		ryanodine receptor agonist
2,2',4,5'-tetrabromodiphenyl ether[no description available]low00aromatic ether;
organobromine compound
hexabromodiphenyl ether 154[no description available]low00aromatic ether;
organobromine compound
bde 183[no description available]low00aromatic ether;
organobromine compound
macitentan[no description available]low00aromatic ether;
organobromine compound;
pyrimidines;
ring assembly;
sulfamides		antihypertensive agent;
endothelin receptor antagonist;
orphan drug
bromophycolide a[no description available]low00diterpenoid;
macrolide;
organobromine compound;
phenols;
tertiary alcohol		anti-HIV agent;
antibacterial agent;
antifungal agent;
antimalarial;
antineoplastic agent;
metabolite
ph 797804[no description available]low00aromatic ether;
benzamides;
organobromine compound;
organofluorine compound;
pyridone		anti-inflammatory agent;
EC 2.7.11.24 (mitogen-activated protein kinase) inhibitor
act-132577[no description available]low00aromatic ether;
organobromine compound;
pyrimidines;
sulfamides		antihypertensive agent;
drug metabolite;
endothelin receptor antagonist;
xenobiotic metabolite
dibromophakellin[no description available]low00alkaloid;
guanidines;
organobromine compound		alpha-adrenergic agonist;
animal metabolite;
marine metabolite
(E,E)-1-bromo-2,5-bis-(4-hydroxystyryl)benzene[no description available]low00organobromine compound;
polyphenol		fluorescent dye
lesinurad[no description available]low00aryl sulfide;
cyclopropanes;
monocarboxylic acid;
naphthalenes;
organobromine compound;
triazoles		uricosuric drug
AZ3451[no description available]low00benzimidazoles;
benzodioxoles;
nitrile;
organobromine compound;
secondary carboxamide		anti-inflammatory agent;
autophagy inducer;
PAR2 negative allosteric modulator
8-bromocyclic gmp[no description available]low003',5'-cyclic purine nucleotide;
organobromine compound		muscle relaxant;
protein kinase G agonist
8-bromo-2'-deoxyguanosine[no description available]low00guanosines;
organobromine compound
ConditionIndicatedRelationship StrengthStudiesTrials
Acinetobacter Infections0low10
Anemia, Fanconi0low10
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Fanconi Anemia0low10
Fanconi Hypoplastic Anemia0low10
Fanconi Pancytopenia0low10
Fanconi Panmyelopathy0low10
Fanconi's Anemia0low10
Infantile Paralysis0low10
Infections, Acinetobacter0low10
Infections, Mimae0low10
Malaria, Falciparum0low10
Mimae Infections0low10
Plasmodium falciparum Malaria0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10