Compounds > 6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile
Page last updated: 2024-08-03 14:03:23

6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile

Description

6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile : no description available [CHeBI]

Cross-References

ID SourceID
PubMed CID44143090
CHEMBL ID577121
SCHEMBL ID3346901
CHEBI ID93410

Synonyms (13)

Synonym
NCGC00181921-01
NCGC00181921-02
MLS002471785
smr001395199
CHEMBL577121 ,
bdbm50303421
6-(3-chlorophenylamino)-9-ethyl-9h-purine-2-carbonitrile
HMS2206H22
HMS3329D15
SCHEMBL3346901
CHEBI:93410
6-(3-chloroanilino)-9-ethyl-2-purinecarbonitrile
Q27165112

Drug Classes (1)

ClassDescription
6-aminopurinesAny compound having 6-aminopurine (adenine) as part of its structure.

Protein Targets (10)

Potency Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
Chain A, CruzipainTrypanosoma cruziPotency0.0141AID2158
LuciferasePhotinus pyralis (common eastern firefly)Potency2.3934AID588342
thioredoxin reductaseRattus norvegicus (Norway rat)Potency35.4813AID588456
BRCA1Homo sapiens (human)Potency8.9125AID624202
ATAD5 protein, partialHomo sapiens (human)Potency4.1078AID504467
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency89.1251AID504333
P53Homo sapiens (human)Potency3.5481AID504706
NPC intracellular cholesterol transporter 1 precursorHomo sapiens (human)Potency3.5481AID485313
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency50.1187AID743266

Inhibition Measurements

ProteinTaxonomyMeasurementAverage (mM)Bioassay(s)
CruzipainTrypanosoma cruziIC500.0092AID444616; AID444617

Bioassays (13)

Assay IDTitleYearJournalArticle
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13ISSN: 1934-9300Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
ISSN: 1552-4922		Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
ISSN: 1557-8127		High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
ISSN: 1945-7170		A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID1745845Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression2022The Journal of biological chemistry, 08, Volume: 298, Issue:8
ISSN: 1083-351X
AID444617Inhibition of recombinant Trypanosoma cruzi cruzain after 5 mins by spectrofluorimetric analysis2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
ISSN: 1520-4804		Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444619Inhibition of recombinant Trypanosoma brucei rhodesain after 5 mins by spectrofluorimetric analysis2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
ISSN: 1520-4804		Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444621Antitrypanosomal activity against Trypanosoma brucei brucei 221 infected in human macrophage after 48 hrs2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
ISSN: 1520-4804		Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444616Inhibition of Trypanosoma cruzi cruzain after 15 mins2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
ISSN: 1520-4804		Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444620Inhibition of recombinant Trypanosoma brucei cathepsin B after 5 mins by spectrofluorimetric analysis2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
ISSN: 1520-4804		Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.
AID444685Antitrypanosomal activity against Trypanosoma cruzi Y trypomastigotes infected in mouse J774 cells at 10 uM after 27 days medium replaced every 48 hrs2010Journal of medicinal chemistry, Jan-14, Volume: 53, Issue:1
ISSN: 1520-4804		Identification and optimization of inhibitors of Trypanosomal cysteine proteases: cruzain, rhodesain, and TbCatB.

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
adenine
0
6-aminopurines;
purine nucleobase		Daphnia magna metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite		00low000000
kinetin
0
6-aminopurines;
furans		cytokinin;
geroprotector		00low000000
6-n-hydroxylaminopurine
0
6-aminopurines;
hydroxylamines;
nucleobase analogue		mutagen;
teratogenic agent		00low000000
arprinocid
0
6-aminopurines00low000000
adefovir
0
6-aminopurines;
ether;
phosphonic acids		antiviral drug;
DNA synthesis inhibitor;
drug metabolite;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent		00low000000
adefovir dipivoxil
0
6-aminopurines;
carbonate ester;
ether;
organic phosphonate		antiviral drug;
DNA synthesis inhibitor;
HIV-1 reverse transcriptase inhibitor;
nephrotoxic agent;
prodrug		00low000000
benzylaminopurine
0
6-aminopurinescytokinin;
plant metabolite		00low000000
nucleocidin
0
6-aminopurines;
adenosines;
diol;
organofluorine compound;
sulfamate ester		antibacterial agent;
bacterial metabolite;
nucleoside antibiotic;
protein synthesis inhibitor;
trypanocidal drug		00low000000
2,8-dihydroxyadenine
0
6-aminopurines;
diol;
heteroaryl hydroxy compound;
oxopurine		human urinary metabolite;
mammalian metabolite;
mouse metabolite;
nephrotoxic agent		00low000000
angustmycin a
0
6-aminopurines00low000000
8-(2-chloro-3,4,5-trimethoxybenzyl)-2-fluoro-9-pent-4-yn-1-yl-9H-purin-6-amine
0
6-aminopurines;
acetylenic compound;
methoxybenzenes;
monochlorobenzenes;
organofluorine compound		antineoplastic agent;
Hsp90 inhibitor		00low000000
8-(Trifluoromethyl)-9H-purin-6-amine
0
6-aminopurinesanticoronaviral agent00low000000
8-hydroxyadenine
0
6-aminopurines;
heteroaryl hydroxy compound;
nucleobase analogue;
oxopurine		bacterial metabolite;
human metabolite		00low000000
gs-7340
0
6-aminopurines;
ether;
isopropyl ester;
L-alanine derivative;
phosphoramidate ester		antiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug		00low000000
ic 87114
0
6-aminopurines;
biaryl;
quinazolines		EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor00low000000
N-[3-[[2-[[4-(dimethylamino)cyclohexyl]amino]-9-propan-2-yl-6-purinyl]amino]phenyl]-2-propenamide
0
6-aminopurines00low000000
6-(3-chloroanilino)-9-cyclopentyl-2-purinecarbonitrile
0
6-aminopurines00low000000
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile
0
6-aminopurines00low000000
6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile
0
6-aminopurines00low000000
SubstanceStudiesClassesRolesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
4-(3,5-difluoroanilino)-6-(2,2-difluoroethylamino)-1,3,5-triazine-2-carbonitrile
1
diamino-1,3,5-triazine2010201014.0high000100
6-(3-chloroanilino)-9-cyclopentyl-2-purinecarbonitrile
1
6-aminopurines2010201014.0high000100
6-(3,5-difluoroanilino)-9-ethyl-2-purinecarbonitrile
1
6-aminopurines2010201014.0high000100
6-(3,5-difluoroanilino)-9-(2,2-difluoroethyl)-2-purinecarbonitrile
1
6-aminopurines2010201014.0high000100
9-(3,5-difluorophenyl)-6-(ethylamino)-2-purinecarbonitrile
1
imidazoles2010201014.0high000100
ConditionIndicatedStudiesFirst YearLast YearAverage AgeRelationship StrengthTrialspre-19901990's2000's2010'spost-2020
Inflammation0
1
2010201014.0high000100
Innate Inflammatory Response0
1
2010201014.0high000100