mast cell secretagogue receptor activity

Definition

Target type: molecularfunction

Combining with basic secretagogues to initiate pseudo-allergic reactions in mast cells. [GOC:sp, PMID:25517090]

Mast cell secretagogue receptor activity is a molecular function that describes the ability of a receptor protein to bind to and be activated by mast cell secretagogues. Mast cell secretagogues are a class of molecules that trigger the release of various inflammatory mediators from mast cells, which are immune cells found in connective tissues.

The activation of mast cell secretagogue receptors leads to a cascade of signaling events within the mast cell. This cascade ultimately results in the exocytosis of granules containing various pre-formed mediators, such as histamine, proteases, and cytokines. These mediators play a critical role in allergic and inflammatory responses.

Examples of mast cell secretagogues include:

- **IgE-antigen complexes:** These complexes are formed when IgE antibodies bind to antigens, such as allergens.
- **Complement fragments:** These are small proteins that are released during the complement activation pathway, an important part of the innate immune system.
- **Neuropeptides:** These are signaling molecules produced by neurons.
- **Certain drugs and toxins:** Some drugs, such as morphine, and toxins, such as bee venom, can also act as mast cell secretagogues.

The binding of a mast cell secretagogue to its receptor can lead to different downstream effects depending on the specific receptor and the nature of the secretagogue. However, the overall outcome is often the release of inflammatory mediators that contribute to allergic reactions, inflammatory diseases, and other pathological conditions.

Therefore, mast cell secretagogue receptor activity is a crucial aspect of immune system function, particularly in the context of allergic and inflammatory responses.'
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Proteins (1)

Compounds (23)