Page last updated: 2024-12-09

1-propan-2-yl-5-benzotriazolecarboxylic acid

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

1-Propan-2-yl-5-benzotriazolecarboxylic acid, also known as **UV-328**, is a **UV absorber** commonly used in various research applications. Here's a breakdown of its properties and significance:

**Structure and Properties:**

* **Structure:** It is a complex molecule with a benzotriazole core, a propan-2-yl group attached at position 1, and a carboxylic acid group at position 5.
* **UV Absorption:** It exhibits strong absorption in the ultraviolet (UV) region of the electromagnetic spectrum, particularly in the range of 280-320 nm.
* **Photostability:** It is relatively stable to UV radiation, meaning it can effectively absorb UV light without undergoing significant degradation itself.

**Why it's Important for Research:**

**1. UV Protection in Materials:**

* **Polymers:** UV-328 is frequently incorporated into polymers (e.g., plastics, coatings) to protect them from UV degradation. UV radiation can cause polymers to weaken, crack, and lose their color, and UV-328 helps prevent this by absorbing the harmful UV light.
* **Sunscreens:** It's used in sunscreens as a filter to block UV radiation from reaching the skin, thereby protecting against sunburn and skin cancer.

**2. Photochemistry Research:**

* **Photostability Studies:** UV-328's photostability makes it a valuable tool for studying the photodegradation of other materials. Researchers use it as a reference standard to compare the stability of different compounds or materials under UV exposure.
* **UV-Vis Spectroscopy:** Its strong UV absorption allows researchers to analyze its properties and quantify its concentration in solutions or materials using UV-Vis spectroscopy.

**3. Biological Research:**

* **Drug Discovery:** UV-328 has shown some potential in biological research. For instance, some studies suggest its potential as an antioxidant or in protecting cells from UV-induced damage.

**Overall, 1-propan-2-yl-5-benzotriazolecarboxylic acid (UV-328) is a versatile compound with significant applications in research.** Its UV absorption and photostability properties make it a crucial tool for protecting materials from UV degradation and for investigating photochemical processes.

Cross-References

ID SourceID
PubMed CID2736690
CHEMBL ID381638
CHEBI ID92275
SCHEMBL ID839123

Synonyms (46)

Synonym
HMS3269G15
ibc-293
ibc293
ibc 293
gtpl1597
SDCCGMLS-0066151.P001
OPREA1_143042
NCGC00159577-01
MAYBRIDGE1_005244 ,
1-isopropyl-benzotraizole-5-carboxylic acid
1-isopropyl-1h-benzotriazole-5-carboxylic acid
bdbm50241028
AKOS000210670
HMS556G08
CHEMBL381638 ,
1-propan-2-ylbenzotriazole-5-carboxylic acid
A820514
1-isopropyl-1h-benzo[d][1,2,3]triazole-5-carboxylic acid
1-isopropylbenzotriazole-5-carboxylic acid
306935-41-1
1-isopropyl-1,2,3-benzotriazole-5-carboxylic acid
FT-0607977
1-(propan-2-yl)-1h-1,2,3-benzotriazole-5-carboxylic acid
PS-3172
1-isopropyl-1h-1,2,3-benzotriazole-5-carboxylic acid
BRD-K15196155-001-01-5
SCHEMBL839123
J-504813
1-(propan-2-yl)-1h-benzotriazole-5-carboxylic acid
DTXSID70371532
RUTVRAJKELSHCC-UHFFFAOYSA-N
1-(1-methylethyl)-1h-benzotriazole-5-carboxylic acid
1h-benzotriazole-5-carboxylic acid, 1-(1-methylethyl)-
1-isopropyl-1h-1,2,3-benzotriazole-5-carboxylic acid, aldrichcpr
mfcd01570664
CCG-248413
CHEBI:92275
gpr109b agonist - cas 306935-41-1
HMS3677O22
Q27078013
HMS3413O22
HMS3742O13
1-isopropyl-1h-1,2,3-benzotriazole-5-carboxylicacid
gpr109 receptor agonist-1
HY-107580
ipbt-5ca; ibc-293
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
benzotriazoles
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (4)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1Homo sapiens (human)Potency25.11890.001815.663839.8107AID894
DNA polymerase kappa isoform 1Homo sapiens (human)Potency39.81070.031622.3146100.0000AID588579
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Activation Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Hydroxycarboxylic acid receptor 3Homo sapiens (human)EC50 (µMol)0.39810.31602.71904.2000AID260310
Hydroxycarboxylic acid receptor 2Homo sapiens (human)EC50 (µMol)0.40000.00871.20176.3096AID388794
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
G protein-coupled receptor signaling pathwayHydroxycarboxylic acid receptor 3Homo sapiens (human)
neutrophil apoptotic processHydroxycarboxylic acid receptor 2Homo sapiens (human)
positive regulation of neutrophil apoptotic processHydroxycarboxylic acid receptor 2Homo sapiens (human)
negative regulation of lipid catabolic processHydroxycarboxylic acid receptor 2Homo sapiens (human)
positive regulation of adiponectin secretionHydroxycarboxylic acid receptor 2Homo sapiens (human)
G protein-coupled receptor signaling pathwayHydroxycarboxylic acid receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (2)

Processvia Protein(s)Taxonomy
G protein-coupled receptor activityHydroxycarboxylic acid receptor 3Homo sapiens (human)
nicotinic acid receptor activityHydroxycarboxylic acid receptor 3Homo sapiens (human)
nicotinic acid receptor activityHydroxycarboxylic acid receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (2)

Processvia Protein(s)Taxonomy
plasma membraneHydroxycarboxylic acid receptor 3Homo sapiens (human)
cell junctionHydroxycarboxylic acid receptor 3Homo sapiens (human)
plasma membraneHydroxycarboxylic acid receptor 3Homo sapiens (human)
plasma membraneHydroxycarboxylic acid receptor 2Homo sapiens (human)
cell junctionHydroxycarboxylic acid receptor 2Homo sapiens (human)
plasma membraneHydroxycarboxylic acid receptor 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (8)

Assay IDTitleYearJournalArticle
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID667489Inhibition of recombinant type N-terminal His6-tagged 2 R67 DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometry2012Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7
Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
AID260310Agonistic activity at GPR109b by cAMP whole cell assay2006Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
AID388794Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production2008Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24
Nicotinic acid receptor agonists.
AID260311Activity against GPR109a upto 100 uM2006Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
AID260312Activity against beta adrenergic receptor2006Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
AID1346334Human HCA3 receptor (Hydroxycarboxylic acid receptors)2006Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4
1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's2 (40.00)29.6817
2010's1 (20.00)24.3611
2020's2 (40.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.87

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.87 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.66 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.87)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (20.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other4 (80.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]