| ID Source | ID |
|---|---|
| PubMed CID | 2736690 |
| CHEMBL ID | 381638 |
| CHEBI ID | 92275 |
| SCHEMBL ID | 839123 |
| Synonym |
|---|
| HMS3269G15 |
| ibc-293 |
| ibc293 |
| ibc 293 |
| gtpl1597 |
| SDCCGMLS-0066151.P001 |
| OPREA1_143042 |
| NCGC00159577-01 |
| MAYBRIDGE1_005244 , |
| 1-isopropyl-benzotraizole-5-carboxylic acid |
| 1-isopropyl-1h-benzotriazole-5-carboxylic acid |
| bdbm50241028 |
| AKOS000210670 |
| HMS556G08 |
| CHEMBL381638 , |
| 1-propan-2-ylbenzotriazole-5-carboxylic acid |
| A820514 |
| 1-isopropyl-1h-benzo[d][1,2,3]triazole-5-carboxylic acid |
| 1-isopropylbenzotriazole-5-carboxylic acid |
| 306935-41-1 |
| 1-isopropyl-1,2,3-benzotriazole-5-carboxylic acid |
| FT-0607977 |
| 1-(propan-2-yl)-1h-1,2,3-benzotriazole-5-carboxylic acid |
| PS-3172 |
| 1-isopropyl-1h-1,2,3-benzotriazole-5-carboxylic acid |
| BRD-K15196155-001-01-5 |
| SCHEMBL839123 |
| J-504813 |
| 1-(propan-2-yl)-1h-benzotriazole-5-carboxylic acid |
| DTXSID70371532 |
| RUTVRAJKELSHCC-UHFFFAOYSA-N |
| 1-(1-methylethyl)-1h-benzotriazole-5-carboxylic acid |
| 1h-benzotriazole-5-carboxylic acid, 1-(1-methylethyl)- |
| 1-isopropyl-1h-1,2,3-benzotriazole-5-carboxylic acid, aldrichcpr |
| mfcd01570664 |
| CCG-248413 |
| CHEBI:92275 |
| gpr109b agonist - cas 306935-41-1 |
| HMS3677O22 |
| Q27078013 |
| HMS3413O22 |
| HMS3742O13 |
| 1-isopropyl-1h-1,2,3-benzotriazole-5-carboxylicacid |
| gpr109 receptor agonist-1 |
| HY-107580 |
| ipbt-5ca; ibc-293 |
| Class | Description |
|---|---|
| benzotriazoles | |
| [compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res] | |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 0.0018 | 15.6638 | 39.8107 | AID894 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 39.8107 | 0.0316 | 22.3146 | 100.0000 | AID588579 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) | EC50 (µMol) | 0.3981 | 0.3160 | 2.7190 | 4.2000 | AID260310 |
| Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) | EC50 (µMol) | 0.4000 | 0.0087 | 1.2017 | 6.3096 | AID388794 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| G protein-coupled receptor signaling pathway | Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) |
| neutrophil apoptotic process | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| positive regulation of neutrophil apoptotic process | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| negative regulation of lipid catabolic process | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| positive regulation of adiponectin secretion | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| G protein-coupled receptor signaling pathway | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| G protein-coupled receptor activity | Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) |
| nicotinic acid receptor activity | Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) |
| nicotinic acid receptor activity | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Process | via Protein(s) | Taxonomy |
|---|---|---|
| plasma membrane | Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) |
| cell junction | Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) |
| plasma membrane | Hydroxycarboxylic acid receptor 3 | Homo sapiens (human) |
| plasma membrane | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| cell junction | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| plasma membrane | Hydroxycarboxylic acid receptor 2 | Homo sapiens (human) |
| [Information is prepared from geneontology information from the June-17-2024 release] | ||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID1347154 | Primary screen GU AMC qHTS for Zika virus inhibitors | 2020 | Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49 | Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors. |
| AID1508630 | Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay | 2021 | Cell reports, 04-27, Volume: 35, Issue:4 | A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome. |
| AID667489 | Inhibition of recombinant type N-terminal His6-tagged 2 R67 DHFR expressed in Escherichia coli BL21 using DHF as substrate by spectrophotometry | 2012 | Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7 | Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase. |
| AID260310 | Agonistic activity at GPR109b by cAMP whole cell assay | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. |
| AID388794 | Activity at GPR109a assessed as inhibition of forskolin-stimulated cAMP production | 2008 | Journal of medicinal chemistry, Dec-25, Volume: 51, Issue:24 | Nicotinic acid receptor agonists. |
| AID260311 | Activity against GPR109a upto 100 uM | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. |
| AID260312 | Activity against beta adrenergic receptor | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. |
| AID1346334 | Human HCA3 receptor (Hydroxycarboxylic acid receptors) | 2006 | Journal of medicinal chemistry, Feb-23, Volume: 49, Issue:4 | 1-Alkyl-benzotriazole-5-carboxylic acids are highly selective agonists of the human orphan G-protein-coupled receptor GPR109b. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 2 (40.00) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (20.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 4 (80.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||