N-acylphosphatidylethanolamine-specific phospholipase D activity
Definition
Target type: molecularfunction
Catalysis of the reaction: H2O + N-acyl-1,2-diacyl-sn-glycero-3-phosphoethanolamine (NAPE) = a 1,2-diacyl-sn-glycero-3-phosphate + an N-acylethanolamine (NAE) + H+. [PMID:14634025, PMID:15878693, RHEA:33159]
N-acylphosphatidylethanolamine-specific phospholipase D (NAPE-PLD) activity is a crucial enzymatic process involved in the hydrolysis of N-acylphosphatidylethanolamine (NAPE), a membrane phospholipid. NAPE-PLD specifically cleaves the phosphodiester bond between the phosphate group and the diacylglycerol moiety of NAPE, releasing N-acylethanolamine (NAE) and phosphatidic acid (PA). NAE, also known as anandamide, is a well-characterized endocannabinoid neurotransmitter that plays a significant role in regulating various physiological functions, including pain perception, appetite, and memory. PA, on the other hand, acts as a signaling molecule involved in diverse cellular processes, including membrane trafficking, cell growth, and cytoskeletal organization. NAPE-PLD activity is tightly regulated and influenced by various factors, such as calcium concentration, protein phosphorylation, and interactions with other proteins. This enzymatic activity is essential for the production of NAE, a critical mediator of endocannabinoid signaling, and for the generation of PA, a versatile signaling molecule involved in numerous cellular pathways. The precise regulation and activity of NAPE-PLD are crucial for maintaining cellular homeostasis and for mediating physiological responses to various stimuli.'
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Proteins (4)
| Protein | Definition | Taxonomy |
|---|---|---|
| N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | An N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IQ20] | Homo sapiens (human) |
| N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D | An N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6IQ20] | Homo sapiens (human) |
| Phospholipase D1 | A phospholipase D1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13393] | Homo sapiens (human) |
| Phospholipase D2 | A phospholipase D2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O14939] | Homo sapiens (human) |
Compounds (16)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| hexachlorophene | hexachlorophene : An organochlorine compound that is diphenylmethane in which each of the phenyl groups is substituted by chlorines at positions 2, 3, and 5, and by a hydroxy group at position 6. An antiseptic that is effective against Gram-positive organisms, it is used in soaps and creams for the treatment of various skin disorders. It is also used in agriculture as an acaricide and fungicide, but is not approved for such use within the European Union. Hexachlorophene: A chlorinated bisphenol antiseptic with a bacteriostatic action against Gram-positive organisms, but much less effective against Gram-negative organisms. It is mainly used in soaps and creams and is an ingredient of various preparations used for skin disorders. (From Martindale, The Extra Pharmacopoeia, 30th ed, p797) | bridged diphenyl fungicide; polyphenol; trichlorobenzene | acaricide; antibacterial agent; antifungal agrochemical; antiseptic drug |
| 1-NA-PP1 | pyrazolopyrimidine | tyrosine kinase inhibitor | |
| raloxifene | raloxifene : A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively. | 1-benzothiophenes; aromatic ketone; N-oxyethylpiperidine; phenols | bone density conservation agent; estrogen antagonist; estrogen receptor modulator |
| lithocholic acid | lithocholate : A bile acid anion that is the conjugate base of lithocholic acid. lithocholic acid : A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action. Lithocholic Acid: A bile acid formed from chenodeoxycholate by bacterial action, usually conjugated with glycine or taurine. It acts as a detergent to solubilize fats for absorption and is itself absorbed. It is used as cholagogue and choleretic. | bile acid; C24-steroid; monohydroxy-5beta-cholanic acid | geroprotector; human metabolite; mouse metabolite |
| 4-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol | stilbenoid | ||
| halopemide | halopemide: structure | ||
| 1-(4-pyridyl)piperazine | 1-(4-pyridyl)piperazine: structure in first source | ||
| 1-(2-pyridinyl)piperazine | 1-(2-pyridinyl)piperazine: metabolite of buspirone & gepirone | ||
| afimoxifene | afimoxifene : A tertiary amino compound that is tamoxifen in which the phenyl group which is in a Z- relationship to the ethyl substituent is hydroxylated at the para- position. It is the active metabolite of tamoxifen. | phenols; tertiary amino compound | antineoplastic agent; estrogen receptor antagonist; metabolite |
| tamoxifen | stilbenoid; tertiary amino compound | angiogenesis inhibitor; antineoplastic agent; bone density conservation agent; EC 1.2.3.1 (aldehyde oxidase) inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; estrogen antagonist; estrogen receptor antagonist; estrogen receptor modulator | |
| nitrocefin | nitrocefin: chromogenic cephalosporin used for detection of beta-lactamase activity; Cefinase is name for nitrocefin on paper disc; RN given refers to (6R-(3(E),6 alpha,7 beta))-isomer; structure for mono-Na salt in second source | ||
| 5-fluoro-2-indolyldeschlorohalopemide | benzimidazoles | ||
| N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)-1-piperidinyl]ethyl]-2-naphthalenecarboxamide | naphthalenecarboxamide | ||
| vu0155069 | |||
| ml298 | |||
| ml299 | ML299: has antineoplastic activity; structure in first source |