Page last updated: 2024-12-10

2-(2-methoxyanilino)-2-(2-phenylmethoxyphenyl)acetonitrile

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

2-(2-Methoxyanilino)-2-(2-phenylmethoxyphenyl)acetonitrile is a **complex organic molecule**, likely a **synthetic compound** rather than a naturally occurring one.

Let's break down why it's difficult to say what its significance is for research:

* **No Established Use:** There's no readily available information about this specific compound's use in research. The name itself doesn't offer any clues about its potential applications.
* **Chemical Structure:** The molecule's structure suggests it might be related to:
* **Aniline derivatives:** The presence of the anilino group (C6H5NH-) suggests potential relevance to the field of **organic chemistry**, particularly in **synthesis and reactions involving amines**.
* **Ether derivatives:** The methoxy and phenylmethoxy groups indicate ether functionalities, which are prevalent in **pharmaceuticals and materials science**.
* **Potential Applications:** Based on its structure, it could potentially be:
* **A precursor:** A starting material for synthesizing other, more complex molecules with desired properties.
* **A ligand:** A molecule that can bind to a metal ion or other molecule, potentially leading to applications in **catalysis or coordination chemistry**.
* **A biological probe:** It might interact with biological targets, making it useful in **drug discovery or studying cellular processes**.

**To understand its importance for research, we'd need more information:**

* **The context of its synthesis or discovery:** Where was this compound synthesized? What was the goal of its creation?
* **Its chemical and biological properties:** What are its melting point, solubility, reactivity? Does it exhibit any biological activity?
* **Published studies or patents:** Are there any publications or patents related to this compound or its potential uses?

Without this additional information, it's impossible to determine its significance in the world of research.

Cross-References

ID SourceID
PubMed CID5123423
CHEMBL ID1509437
CHEBI ID116098

Synonyms (18)

Synonym
smr000219764
MLS000589171
(2-benzyloxy-phenyl)-(2-methoxy-phenylamino)-acetonitrile
AJ-292/42152724
[2-(benzyloxy)phenyl](2-methoxyanilino)acetonitrile
CHEBI:116098
AKOS005481482
HMS2539M04
2-(2-methoxyanilino)-2-(2-phenylmethoxyphenyl)acetonitrile
[2-(benzyloxy)phenyl][(2-methoxyphenyl)amino]acetonitrile
STK555322
bdbm50447010
CHEMBL1509437 ,
compound d24 [pmid: 24374347]
gtpl8834
2-[(2-methoxyphenyl)amino]-2-[2-(phenylmethoxy)phenyl]acetonitrile
664972-15-0
Q27076865
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (2)

ClassDescription
aromatic etherAny ether in which the oxygen is attached to at least one aryl substituent.
substituted aniline
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (12)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Chain A, Putative fructose-1,6-bisphosphate aldolaseGiardia intestinalisPotency15.81140.140911.194039.8107AID2451
Chain A, 2-oxoglutarate OxygenaseHomo sapiens (human)Potency39.81070.177814.390939.8107AID2147
Chain A, Ferritin light chainEquus caballus (horse)Potency50.11875.623417.292931.6228AID485281
TDP1 proteinHomo sapiens (human)Potency29.09290.000811.382244.6684AID686978; AID686979
Smad3Homo sapiens (human)Potency35.48130.00527.809829.0929AID588855
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency17.78280.011212.4002100.0000AID1030
P53Homo sapiens (human)Potency50.11870.07319.685831.6228AID504706
chromobox protein homolog 1Homo sapiens (human)Potency89.12510.006026.168889.1251AID540317
parathyroid hormone/parathyroid hormone-related peptide receptor precursorHomo sapiens (human)Potency39.81073.548119.542744.6684AID743266
gemininHomo sapiens (human)Potency0.52340.004611.374133.4983AID624296; AID624297
DNA dC->dU-editing enzyme APOBEC-3G isoform 1Homo sapiens (human)Potency14.12540.058010.694926.6086AID602310
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Phosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)IC50 (µMol)12.40001.00001.78574.0000AID1068359
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (5)

Processvia Protein(s)Taxonomy
sphingomyelin biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
sphingolipid biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
regulation of bone mineralizationPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
ceramide phosphoethanolamine biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
ceramide biosynthetic processPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (5)

Processvia Protein(s)Taxonomy
ceramide phosphoethanolamine synthase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
protein bindingPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
kinase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
sphingomyelin synthase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
ceramide cholinephosphotransferase activityPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (5)

Processvia Protein(s)Taxonomy
Golgi membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
nucleoplasmPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
Golgi apparatusPhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
plasma membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
Golgi membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
endoplasmic reticulum membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
plasma membranePhosphatidylcholine:ceramide cholinephosphotransferase 2Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID1068359Inhibition of SMS2 (unknown origin) expressed in H5 insect cells using C6-NBD-Cer as substrate after 1 hr2014European journal of medicinal chemistry, Feb-12, Volume: 73Identification of small molecule sphingomyelin synthase inhibitors.
AID1068357Inhibition of sphingomyelin synthase in ICR mouse liver homogenates using C6-NBD-Cer as substrate after 2 hrs2014European journal of medicinal chemistry, Feb-12, Volume: 73Identification of small molecule sphingomyelin synthase inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (6)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (16.67)29.6817
2010's4 (66.67)24.3611
2020's1 (16.67)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.35

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.35 (24.57)
Research Supply Index1.95 (2.92)
Research Growth Index4.30 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.35)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]