dinucleotide insertion or deletion binding

Definition

Target type: molecularfunction

Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion. [GOC:vk]

Dinucleotide insertion or deletion binding is a molecular function associated with proteins that specifically recognize and bind to DNA sequences containing dinucleotide insertions or deletions. These proteins play crucial roles in DNA repair, replication, and recombination processes.

Dinucleotide insertions or deletions are mutations that involve the addition or removal of two consecutive nucleotides within a DNA sequence. These mutations can disrupt the reading frame of a gene, leading to the production of non-functional proteins.

Proteins involved in dinucleotide insertion or deletion binding typically possess specialized domains or motifs that allow them to recognize and interact with the altered DNA structure. These domains often interact with the distorted DNA backbone or the exposed bases at the insertion or deletion site.

The binding of these proteins to dinucleotide insertions or deletions can trigger a variety of downstream events, depending on the specific protein and the cellular context. For example, some proteins may recruit other DNA repair enzymes to the site of damage, while others may act as a roadblock to prevent further replication or transcription.

Dinucleotide insertion or deletion binding is an essential process for maintaining genomic integrity and preventing the accumulation of harmful mutations. Mutations in genes encoding these proteins can lead to increased susceptibility to cancer and other diseases.'
"

Proteins (1)

Compounds (7)