dinucleotide insertion or deletion binding
Definition
Target type: molecularfunction
Binding to a double-stranded DNA region containing a dinucleotide insertion or deletion. [GOC:vk]
Dinucleotide insertion or deletion binding is a molecular function associated with proteins that specifically recognize and bind to DNA sequences containing dinucleotide insertions or deletions. These proteins play crucial roles in DNA repair, replication, and recombination processes.
Dinucleotide insertions or deletions are mutations that involve the addition or removal of two consecutive nucleotides within a DNA sequence. These mutations can disrupt the reading frame of a gene, leading to the production of non-functional proteins.
Proteins involved in dinucleotide insertion or deletion binding typically possess specialized domains or motifs that allow them to recognize and interact with the altered DNA structure. These domains often interact with the distorted DNA backbone or the exposed bases at the insertion or deletion site.
The binding of these proteins to dinucleotide insertions or deletions can trigger a variety of downstream events, depending on the specific protein and the cellular context. For example, some proteins may recruit other DNA repair enzymes to the site of damage, while others may act as a roadblock to prevent further replication or transcription.
Dinucleotide insertion or deletion binding is an essential process for maintaining genomic integrity and preventing the accumulation of harmful mutations. Mutations in genes encoding these proteins can lead to increased susceptibility to cancer and other diseases.'
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Proteins (1)
| Protein | Definition | Taxonomy |
|---|---|---|
| Proliferating cell nuclear antigen | A proliferating cell nuclear antigen that is encoded in the genome of human. [PRO:DNx] | Homo sapiens (human) |
Compounds (7)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| 3,3',5-triiodothyroacetic acid | tiratricol : A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)acetic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxy-3-iodophenoxy group. It is a thyroid hormone analogue that has been used in the treatment of thyroid hormone resistance syndrome. | ||
| 3,3',5-triiodothyropropionic acid | aromatic ether | ||
| thyroxine | thyroxine : An iodothyronine compound having iodo substituents at the 3-, 3'-, 5- and 5'-positions. Thyroxine: The major hormone derived from the thyroid gland. Thyroxine is synthesized via the iodination of tyrosines (MONOIODOTYROSINE) and the coupling of iodotyrosines (DIIODOTYROSINE) in the THYROGLOBULIN. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form TRIIODOTHYRONINE which exerts a broad spectrum of stimulatory effects on cell metabolism. | 2-halophenol; iodophenol; L-phenylalanine derivative; non-proteinogenic L-alpha-amino acid; thyroxine; thyroxine zwitterion | antithyroid drug; human metabolite; mouse metabolite; thyroid hormone |
| triiodothyronine | 3,3',5-triiodo-L-thyronine : An iodothyronine compound having iodo substituents at the 3-, 3'- and 5-positions. Although some is produced in the thyroid, most of the 3,3',5-triiodo-L-thyronine in the body is generated by mono-deiodination of L-thyroxine in the peripheral tissues. Its metabolic activity is about 3 to 5 times that of L-thyroxine. The sodium salt is used in the treatment of hypothyroidism. Triiodothyronine: A T3 thyroid hormone normally synthesized and secreted by the thyroid gland in much smaller quantities than thyroxine (T4). Most T3 is derived from peripheral monodeiodination of T4 at the 5' position of the outer ring of the iodothyronine nucleus. The hormone finally delivered and used by the tissues is mainly T3. | 2-halophenol; amino acid zwitterion; iodophenol; iodothyronine | human metabolite; mouse metabolite; thyroid hormone |
| 3,5-diiodothyronine, (l)-isomer | phenylalanine derivative | ||
| 3,3'-diiodothyronine | 3,3'-diiodothyronine: RN given refers to unlabeled cpd without isomeric designation | 3,3'-diiodothyronine; amino acid zwitterion | human metabolite |
| 3,5-diiodothyropropionic acid | 3,5-diiodothyropropionic acid : A monocarboxylic acid that is (4-hydroxy-3,5-diiodophenyl)propanoic acid in which the phenolic hydroxy group has been replaced by a 4-hydroxyphenyl group. An ionotropic analogue of L-thyroxine. 3,5-diiodothyropropionic acid: a cardiotonic thyroid hormone analog | aromatic ether; monocarboxylic acid; organoiodine compound; phenols |