Target type: molecularfunction
Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle. [GOC:ai]
Creatine transmembrane transporter activity involves the facilitated movement of creatine across cell membranes. This process is crucial for maintaining cellular energy homeostasis, particularly in tissues with high energy demands such as skeletal muscle and brain. Creatine, a nitrogenous compound, plays a vital role in energy metabolism by acting as a phosphate reservoir, providing a rapid source of energy for ATP production. The creatine transporter, encoded by the SLC6A8 gene, is a transmembrane protein that utilizes the electrochemical gradient of sodium ions to drive the uptake of creatine into cells. This transport mechanism is highly specific for creatine, ensuring efficient delivery of this crucial metabolite to its target tissues. The function of the creatine transporter is tightly regulated, and dysregulation of this transport activity has been implicated in various pathological conditions, including muscular dystrophies, neurological disorders, and cancer.'
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| Protein | Definition | Taxonomy |
|---|---|---|
| Sodium- and chloride-dependent GABA transporter 2 | A sodium- and chloride-dependent GABA transporter 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9NSD5] | Homo sapiens (human) |
| Sodium- and chloride-dependent creatine transporter 1 | A sodium- and chloride-dependent creatine transporter 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P48029] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| gamma-aminobutyric acid | gamma-aminobutyric acid : A gamma-amino acid that is butanoic acid with the amino substituent located at C-4. gamma-Aminobutyric Acid: The most common inhibitory neurotransmitter in the central nervous system. | amino acid zwitterion; gamma-amino acid; monocarboxylic acid | human metabolite; neurotransmitter; Saccharomyces cerevisiae metabolite; signalling molecule |
| beta-alanine | amino acid zwitterion; beta-amino acid | agonist; fundamental metabolite; human metabolite; inhibitor; neurotransmitter | |
| 2,3-diaminopropionic acid | 3-aminoalanine : A diamino acid that is alanine in which one of the hydrogens of the methyl group is replaced by an amino group. | alanine derivative; amino acid zwitterion; beta-amino acid; diamino acid; non-proteinogenic alpha-amino acid | Escherichia coli metabolite |
| creatine | glycine derivative; guanidines; zwitterion | geroprotector; human metabolite; mouse metabolite; neuroprotective agent; nutraceutical | |
| guvacine | guvacine : A alpha,beta-unsaturated monocarboxylic acid that is nicotinic acid which has been hydrogenated at the 1-2 and 5-6 positions of the pyridine ring. guvacine: RN given refers to parent cpd | alpha,beta-unsaturated monocarboxylic acid; beta-amino acid; pyridine alkaloid; secondary amino compound; tetrahydropyridine | GABA reuptake inhibitor; plant metabolite |
| nipecotic acid | nipecotic acid : A piperidinemonocarboxylic acid that is piperidine in which one of the hydrogens at position 3 is substituted by a carboxylic acid group. nipecotic acid: RN given refers to cpd without isomeric designation | beta-amino acid; piperidinemonocarboxylic acid | |
| n-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide | N-(1-benzyl-4-piperidinyl)-2,4-dichlorobenzamide: inhibits the betaine-GABA transporter 1; structure in first source | ||
| 2-ethoxy-N-[1-(phenylmethyl)-4-piperidinyl]benzamide | piperidines | ||
| nnc 05-2090 | NNC 05-2090: structure given in first source | carbazoles | |
| snap 5114 |