Page last updated: 2024-10-24

protein serine/threonine phosphatase complex

Definition

Target type: cellularcomponent

A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein. [GOC:bf]

Protein serine/threonine phosphatase complexes are intricate assemblies of proteins that play a critical role in cellular signaling and regulation. These complexes often comprise a catalytic subunit, which possesses the enzymatic activity to dephosphorylate serine and threonine residues on target proteins. The catalytic subunit is typically associated with one or more regulatory subunits that modulate its activity and substrate specificity. Regulatory subunits can include scaffolding proteins that provide structural support and promote the assembly of the complex, as well as targeting subunits that direct the complex to specific cellular locations or substrates. The cellular component of protein serine/threonine phosphatase complexes can vary depending on the specific complex and its function. Some complexes reside in the cytoplasm, where they regulate intracellular signaling pathways, while others associate with membranes, where they modulate the activity of membrane-bound proteins. Additionally, some complexes are localized to the nucleus, where they regulate gene expression and other nuclear processes. The localization and composition of protein serine/threonine phosphatase complexes are tightly regulated, allowing for precise control of their activity in different cellular compartments. This intricate regulation ensures that these complexes can effectively respond to diverse cellular stimuli and maintain cellular homeostasis.'
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Proteins (4)

ProteinDefinitionTaxonomy
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoformA protein phosphatase 3 catalytic subunit alpha that is encoded in the genome of human. [PRO:CNA, UniProtKB:Q08209]Homo sapiens (human)
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoformA serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform that is encoded in the genome of human. [PRO:CNA, UniProtKB:P67775]Homo sapiens (human)
Calcineurin subunit B type 1A calcineurin subunit B type 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P63098]Homo sapiens (human)
Serine/threonine-protein phosphatase 2B catalytic subunit beta isoformA serine/threonine-protein phosphatase 2B catalytic subunit beta isoform that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16298]Homo sapiens (human)

Compounds (5)

CompoundDefinitionClassesRoles
tacrolimustacrolimus (anhydrous) : A macrolide lactam containing a 23-membered lactone ring, originally isolated from the fermentation broth of a Japanese soil sample that contained the bacteria Streptomyces tsukubaensis.

Tacrolimus: A macrolide isolated from the culture broth of a strain of Streptomyces tsukubaensis that has strong immunosuppressive activity in vivo and prevents the activation of T-lymphocytes in response to antigenic or mitogenic stimulation in vitro.
macrolide lactambacterial metabolite;
immunosuppressive agent
okadaic acidpolycyclic ethercalcium ionophore;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
marine metabolite
tamoxifenstilbenoid;
tertiary amino compound
angiogenesis inhibitor;
antineoplastic agent;
bone density conservation agent;
EC 1.2.3.1 (aldehyde oxidase) inhibitor;
EC 2.7.11.13 (protein kinase C) inhibitor;
estrogen antagonist;
estrogen receptor antagonist;
estrogen receptor modulator
cyclosporineramihyphin A: one of the metabolites produced by Fusarium sp. S-435; RN given refers to cpd with unknown MFhomodetic cyclic peptideanti-asthmatic drug;
anticoronaviral agent;
antifungal agent;
antirheumatic drug;
carcinogenic agent;
dermatologic drug;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
geroprotector;
immunosuppressive agent;
metabolite
bi 201335faldaprevir: inhibits hepatitis C virus NS3 protease