IMP metabolic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways involving IMP, inosine monophosphate. [GOC:go_curators]

The IMP metabolic process encompasses the biosynthesis and degradation of inosine monophosphate (IMP), a crucial purine nucleotide involved in various cellular functions. IMP serves as a precursor for both adenosine monophosphate (AMP) and guanosine monophosphate (GMP), the building blocks of RNA and DNA.

The biosynthesis of IMP commences with the initial commitment step catalyzed by the enzyme glutamine-PRPP amidotransferase, which converts phosphoribosyl pyrophosphate (PRPP) to phosphoribosylamine. Subsequent steps involve the incorporation of glycine, formate, and aspartate, leading to the formation of IMP.

The degradation of IMP can occur through two pathways: the purine nucleoside phosphorylase pathway and the xanthine oxidase pathway. The purine nucleoside phosphorylase pathway converts IMP to inosine, which is then further degraded to hypoxanthine. The xanthine oxidase pathway involves the oxidation of hypoxanthine to xanthine and ultimately to uric acid.

IMP metabolism is tightly regulated to ensure proper purine nucleotide homeostasis. Feedback inhibition by AMP and GMP regulates the activity of key enzymes involved in IMP biosynthesis. Moreover, the intracellular concentration of IMP influences the synthesis of AMP and GMP, thus impacting the overall purine nucleotide pool.

IMP metabolic process plays a critical role in cell growth, proliferation, and differentiation. Disruptions in IMP metabolism have been linked to various diseases, including gout, Lesch-Nyhan syndrome, and certain cancers. Therefore, understanding the intricacies of IMP metabolism holds significant implications for therapeutic strategies targeting these disorders.'
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Proteins (2)

Compounds (12)