GDP-mannose biosynthetic process

Definition

Target type: biologicalprocess

The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai]

The GDP-mannose biosynthetic process is a crucial metabolic pathway that synthesizes GDP-mannose, a nucleotide sugar essential for the production of various glycoconjugates, including N-linked glycans, O-linked glycans, and glycoproteins. This process occurs in the cytoplasm of eukaryotic cells and involves a series of enzymatic steps.

The pathway begins with the conversion of mannose-6-phosphate (M6P) to mannose-1-phosphate (M1P) by the enzyme phosphoglucomutase (PGM). M1P is then reacted with guanosine triphosphate (GTP) by the enzyme GDP-mannose pyrophosphorylase (GMP) to generate GDP-mannose and inorganic pyrophosphate (PPi).

The reaction catalyzed by GMP is highly specific and irreversible, ensuring the efficient production of GDP-mannose. The enzyme GMP is regulated by feedback inhibition by GDP-mannose, ensuring that the synthesis of this essential nucleotide sugar is tightly controlled.

GDP-mannose serves as a donor of mannose residues for various glycosylation reactions. These reactions are catalyzed by glycosyltransferases, which transfer mannose from GDP-mannose to specific acceptor molecules.

The GDP-mannose biosynthetic process is essential for cell viability and plays crucial roles in a wide range of biological processes, including protein folding, cell signaling, cell adhesion, and immune response.'
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Proteins (4)

Compounds (10)