Page last updated: 2024-10-24
folic acid-containing compound metabolic process
Definition
Target type: biologicalprocess
The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. [GOC:ai, GOC:mah]
Folic acid-containing compound metabolic process involves a series of biochemical reactions that are essential for the synthesis of purines and pyrimidines, which are the building blocks of DNA and RNA. These processes also play a role in the synthesis of amino acids, such as methionine and glycine. The process begins with the uptake of folic acid from the diet, which is then converted to tetrahydrofolic acid (THF) by the enzyme dihydrofolate reductase (DHFR). THF serves as a coenzyme in various metabolic reactions, including the transfer of one-carbon units. One-carbon units are required for the synthesis of various molecules, such as thymine, purines, and serine. Folate metabolism is crucial for cell growth and division, and deficiencies in folate can lead to a variety of health problems, including anemia, neural tube defects, and cardiovascular disease. This process is essential for the function of cells and the maintenance of overall health.'
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Proteins (2)
| Protein | Definition | Taxonomy |
|---|---|---|
| Folylpolyglutamate synthase, mitochondrial | A folylpolyglutamate synthase, mitochondrial that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q05932] | Homo sapiens (human) |
| Glutamate carboxypeptidase 2 | A glutamate carboxypeptidase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q04609] | Homo sapiens (human) |
Compounds (21)
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| glutamic acid | glutamic acid : An alpha-amino acid that is glutaric acid bearing a single amino substituent at position 2. Glutamic Acid: A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. | glutamic acid; glutamine family amino acid; L-alpha-amino acid; proteinogenic amino acid | Escherichia coli metabolite; ferroptosis inducer; micronutrient; mouse metabolite; neurotransmitter; nutraceutical |
| quisqualic acid | Quisqualic Acid: An agonist at two subsets of excitatory amino acid receptors, ionotropic receptors that directly control membrane channels and metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores. The compound is obtained from the seeds and fruit of Quisqualis chinensis. | non-proteinogenic alpha-amino acid | |
| plasmenylserine | O-phospho-L-serine : The L-enantiomer of O-phosphoserine. O-phosphoserine : A serine derivative that is serine substituted at the oxygen atom by a phosphono group. plasmenylserine: RN given refers to (L)-isomer | O-phosphoserine | EC 1.4.7.1 [glutamate synthase (ferredoxin)] inhibitor; EC 2.5.1.49 (O-acetylhomoserine aminocarboxypropyltransferase) inhibitor; EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor; Escherichia coli metabolite; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite |
| 3'-amino-2',3'-dideoxythymidine | |||
| methotrexate | dicarboxylic acid; monocarboxylic acid amide; pteridines | abortifacient; antimetabolite; antineoplastic agent; antirheumatic drug; dermatologic drug; DNA synthesis inhibitor; EC 1.5.1.3 (dihydrofolate reductase) inhibitor; immunosuppressive agent | |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | |||
| serine o-sulfate | L-serine O-sulfate : A non-proteinogenic L-alpha-amino acid that is the O-sulfo derivative of L-serine. serine O-sulfate: RN given refers to (L)-isomer | L-serine derivative; non-proteinogenic L-alpha-amino acid; O-sulfoamino acid | |
| aminopterin | Aminopterin: A folic acid derivative used as a rodenticide that has been shown to be teratogenic. | dicarboxylic acid | EC 1.5.1.3 (dihydrofolate reductase) inhibitor; mutagen |
| isospaglumic acid | Ac-Asp-Glu : A dipeptide composed of N-acetyl-L-aspartic acid and L-glutamic acid joined by a peptide linkage. isospaglumic acid: mediator in the sensitivity of animals to hyperbaric oxygenation; Naaxia is the tradename; apparently can have both a neuroprotective and a neurotoxic effect | dipeptide | human metabolite |
| sq 14,603 | 2-benzyl-3-mercaptopropanoic acid: structure; carboxypeptidase inhibitor | ||
| willardiine | 3-(uracil-1-yl)-L-alanine : The 3-(uracil-1-yl) derivative of L-alanine. willardiine: isolated from seeds of Acacia willariana; structure | amino acid zwitterion; L-alanine derivative; non-proteinogenic L-alpha-amino acid | |
| gamma-glutamyl hydroxamate | glutamine hydroxamate : A hydroxamic acid that is L-glutamine hydroxylated at N-5. | amino acid zwitterion; glutamic acid derivative; hydroxamic acid | |
| phenobarbital sodium | 2-(phosphonomethyl)pentanedioic acid: an N-acetylated alpha-linked acidic dipeptidase (NAALADase) antagonist | ||
| gpi 5693 | 2-(3-mercaptopropyl)pentanedioic acid: inhibits glutamate carboxypeptidase II; structure in first source | ||
| zj43 | ZJ43: N-acetylaspartylglutamate (NAAG) peptidase inhibitor; structure in first source | ||
| psma-617 | PSMA-617: inhibits prostate-specific membrane antigen; structure in first source | ||
| folic acid | folcysteine: used to promote fertility in chickens vitamin B9 : Any B-vitamin that exhibits biological activity against vitamin B9 deficiency. Vitamin B9 refers to the many forms of folic acid and its derivatives, including tetrahydrofolic acid (the active form), methyltetrahydrofolate (the primary form found in blood), methenyltetrahydrofolate, folinic acid amongst others. They are present in abundance in green leafy vegetables, citrus fruits, and animal products. Lack of vitamin B9 leads to anemia, a condition in which the body cannot produce sufficient number of red blood cells. Symptoms of vitamin B9 deficiency include fatigue, muscle weakness, and pale skin. | folic acids; N-acyl-amino acid | human metabolite; mouse metabolite; nutrient |
| n-(4(n-((2-amino-4-hydroxy-6-quinazolinyl)methyl)prop-2-ynylamino)benzoyl)-l-glutamic acid | |||
| 1843u89 | 1843U89: structure given in first source; a folate analog | ||
| 5,11-methenyltetrahydrohomofolate | |||
| 5,6,7,8-tetrahydrofolic acid | tetrahydrofolate : A folate obtained by deprotonation of any tetrahydrofolic acid. tetrahydrofolic acid : A group of heterocyclic compounds based on the 5,6,7,8-tetrahydropteroic acid skeleton conjugated with one or more L-glutamic acid units. | tetrahydrofolic acid | Saccharomyces cerevisiae metabolite |