Target type: biologicalprocess
The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. [ISBN:0198506732]
| Protein | Definition | Taxonomy |
|---|---|---|
| Natriuretic peptides A | An atrial natriuretic factor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P01160] | Homo sapiens (human) |
| Guanylate cyclase soluble subunit beta-1 | A guanylate cyclase soluble subunit beta-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02153] | Homo sapiens (human) |
| Guanylate cyclase soluble subunit alpha-1 | A guanylate cyclase soluble subunit alpha-1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q02108] | Homo sapiens (human) |
| Guanylate cyclase soluble subunit alpha-2 | A guanylate cyclase soluble subunit alpha-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P33402] | Homo sapiens (human) |
| Atrial natriuretic peptide receptor 1 | An atrial natriuretic peptide receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P16066] | Homo sapiens (human) |
| Natriuretic peptides A | An atrial natriuretic factor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P01160] | Homo sapiens (human) |
| Guanylate cyclase soluble subunit beta-2 | A guanylate cyclase soluble subunit beta-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O75343] | Homo sapiens (human) |
| Compound | Definition | Classes | Roles |
|---|---|---|---|
| gemfibrozil | aromatic ether | antilipemic drug | |
| 6-anilino-5,8-quinolinedione | 6-anilino-5,8-quinolinedione : A quinolone that is quinoline-5,8-dione in which the hydrogen at position 6 is replaced by an anilino group. 6-anilino-5,8-quinolinedione: structure given in first source; SRS-A & guanylate cyclase antagonist | aminoquinoline; aromatic amine; p-quinones; quinolone | antineoplastic agent; EC 4.6.1.2 (guanylate cyclase) inhibitor |
| ns 2028 | NS 2028: structure in first source | ||
| 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole | 3-(5'-hydroxymethyl-2'-furyl)-1-benzylindazole: antineoplastic; activates platelet guanylate cyclase; a radiosensitizing agent and guanylate cyclase activator; structure in first source lificiguat : A member of the class of indazoles that is 1H-indazole which is substituted by a benzyl group at position 1 and a 5-(hydroxymethyl)-2-furyl group at position 3. It is an activator of soluble guanylate cyclase and inhibits platelet aggregation. | aromatic primary alcohol; furans; indazoles | antineoplastic agent; apoptosis inducer; platelet aggregation inhibitor; soluble guanylate cyclase activator; vasodilator agent |
| benzydamine | benzydamine : A member of the class of indazoles carrying benzyl and 3-(dimethylamino)propyl groups at positions 1 and 3 respectively. A locally-acting nonsteroidal anti-inflammatory drug that also exhibits local anaesthetic and analgesic properties. Benzydamine: A benzyl-indazole having analgesic, antipyretic, and anti-inflammatory effects. It is used to reduce post-surgical and post-traumatic pain and edema and to promote healing. It is also used topically in treatment of RHEUMATIC DISEASES and INFLAMMATION of the mouth and throat. | aromatic ether; indazoles; tertiary amino compound | analgesic; central nervous system stimulant; hallucinogen; local anaesthetic; non-steroidal anti-inflammatory drug |
| bay 41-8543 | BAY 41-8543: structure in first source | pyrazolopyridine | |
| atrial natriuretic factor | Atrial Natriuretic Factor: A potent natriuretic and vasodilatory peptide or mixture of different-sized low molecular weight PEPTIDES derived from a common precursor and secreted mainly by the HEART ATRIUM. All these peptides share a sequence of about 20 AMINO ACIDS. | polypeptide | |
| mk-7246 | |||
| natriuretic peptide, brain | Natriuretic Peptide, Brain: A PEPTIDE that is secreted by the BRAIN and the HEART ATRIA, stored mainly in cardiac ventricular MYOCARDIUM. It can cause NATRIURESIS; DIURESIS; VASODILATION; and inhibits secretion of RENIN and ALDOSTERONE. It improves heart function. It contains 32 AMINO ACIDS. | polypeptide |