Natriuretic peptides A

An atrial natriuretic factor that is encoded in the genome of human. [PRO:DNx, UniProtKB:P01160]

Synonyms

Atrial natriuretic factor prohormone;
proANF;
Atrial natriuretic peptide prohormone;
preproANP;
proANP;
Atriopeptigen;
Cardiodilatin;
CDD;
preproCDD-ANF

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (100.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (1)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
mk-7246	Homo sapiens (human)	IC50	34.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
signaling receptor binding	molecular function	Binding to one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:bf, GOC:ceb, ISBN:0198506732]
neuropeptide hormone activity	molecular function	The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones. [GOC:mah]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
hormone receptor binding	molecular function	Binding to a receptor for a hormone. [GOC:ai]
neuropeptide receptor binding	molecular function	Binding to a neuropeptide receptor. [GOC:kmv, GOC:mah]
hormone activity	molecular function	The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process. [GOC:dph, GOC:mah, ISBN:0198506732]

Located In

This protein is located in 4 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
cell projection	cellular component	A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
perikaryon	cellular component	The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
collagen-containing extracellular matrix	cellular component	An extracellular matrix consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that provides not only essential physical scaffolding for the cellular constituents but can also initiate crucial biochemical and biomechanical cues required for tissue morphogenesis, differentiation and homeostasis. The components are secreted by cells in the vicinity and form a sheet underlying or overlying cells such as endothelial and epithelial cells. [GOC:BHF, GOC:rph, PMID:21123617]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 22 target(s):

Target	Category	Definition
cardiac conduction system development	biological process	The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat. [GOC:mtg_heart]
aortic valve morphogenesis	biological process	The process in which the structure of the aortic valve is generated and organized. [GOC:mtg_heart]
protein folding	biological process	The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. [GOC:go_curators, GOC:rb]
receptor guanylyl cyclase signaling pathway	biological process	The series of molecular signals initiated by an extracellular ligand binding to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:mah, GOC:signaling, PMID:16815030]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]
female pregnancy	biological process	The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth. [ISBN:0192800825]
regulation of blood pressure	biological process	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
positive regulation of heart rate	biological process	Any process that activates or increases the frequency or rate of heart contraction. [GOC:dph, GOC:tb]
cardiac muscle hypertrophy in response to stress	biological process	The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle]
response to muscle stretch	biological process	Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length. [GOC:BHF, GOC:vk, PMID:14583192]
sodium ion export across plasma membrane	biological process	The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:vw, PMID:14674689]
vasodilation	biological process	An increase in the internal diameter of blood vessels, especially arterioles or capillaries, due to relaxation of smooth muscle cells that line the vessels, and usually resulting in a decrease in blood pressure. [GOC:pr, ISBN:0192800981]
negative regulation of JUN kinase activity	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of JUN kinase activity. [GOC:jl]
regulation of atrial cardiac muscle cell membrane repolarization	biological process	Any process that modulates the establishment or extent of a membrane potential in the polarizing direction towards the resting potential in an atrial cardiomyocyte. [GOC:dph, GOC:tb]
positive regulation of cardiac muscle contraction	biological process	Any process that increases the frequency, rate or extent of cardiac muscle contraction. [GOC:dph, GOC:tb]
regulation of high voltage-gated calcium channel activity	biological process	Any process that modulates the frequency, rate or extent of high voltage-gated calcium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:12754254]
positive regulation of delayed rectifier potassium channel activity	biological process	Any process that activates or increases the frequency, rate or extent of delayed rectifier potassium channel activity. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:11299204]
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel	biological process	Any process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048]
positive regulation of potassium ion export across plasma membrane	biological process	Any process that activates or increases the frequency, rate or extent of potassium ion export across the plasma membrane. [GO_REF:0000058, GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:rl, GOC:TermGenie, PMID:19646991]
cGMP-mediated signaling	biological process	An intracellular signaling cassette that starts with production of cyclic GMP (cGMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]
negative regulation of systemic arterial blood pressure	biological process	The process that reduces the force with which blood travels through the systemic arterial circulatory system. [GOC:mtg_cardio]
cGMP biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate. [ISBN:0198506732]