An antagonist that binds to and blocks the activity of prostaglandin receptors.
ChEBI ID: 138887
| Member | Definition | Class |
|---|---|---|
| l-798106 | An N-sulfonylcarboxamide resulting from the formal condensation of the carboxy group of o-naphthalen-2-ylcinnamic acid with the sulfonamide group of 5-bromo-2-methoxybenzenesulfonamide. It is a selective antagonist for the prostanoid receptor EP3, a prostaglandin receptor for prostaglandin E2 (PGE2). | L-798106 |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (40.00) | 29.6817 |
| 2010's | 3 (30.00) | 24.3611 |
| 2020's | 3 (30.00) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 10 (100.00%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 23.7101 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Prostacyclin receptor | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Prostaglandin D2 receptor | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Prostaglandin E2 receptor EP1 subtype | Homo sapiens (human) | Ki | 39.0000 | 1 | 1 |
| Prostaglandin E2 receptor EP2 subtype | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | Ki | 0.0038 | 2 | 2 |
| Prostaglandin E2 receptor EP4 subtype | Homo sapiens (human) | Ki | 0.8900 | 1 | 1 |
| Prostaglandin F2-alpha receptor | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Thromboxane A2 receptor | Homo sapiens (human) | Ki | 0.5000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Prostaglandin E2 receptor EP3 subtype | Homo sapiens (human) | Kb | 0.0006 | 1 | 1 |