Pathways > Uptake and actions of bacterial toxins
Page last updated: 2024-10-06

Uptake and actions of bacterial toxins

Proteins (36)

ProteinSynonymsTaxonomy
Heat shock protein HSP 90-alphaEC 3.6.4.10; Heat shock 86 kDa; HSP 86; HSP86; Lipopolysaccharide-associated protein 2; LAP-2; LPS-associated protein 2; Renal carcinoma antigen NY-REN-38Homo sapiens (human)
Heat shock protein HSP 90-betaHSP 90; Heat shock 84 kDa; HSP 84; HSP84Homo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 2MAP kinase kinase 2; MAPKK 2; EC 2.7.12.2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2Homo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 1MAP kinase kinase 1; MAPKK 1; MKK1; EC 2.7.12.2; ERK activator kinase 1; MAPK/ERK kinase 1; MEK 1Homo sapiens (human)
FurinEC 3.4.21.75; Dibasic-processing enzyme; Paired basic amino acid residue-cleaving enzyme; PACEHomo sapiens (human)
Botulinum neurotoxin type A BoNT/A; Bontoxilysin-A; BOTOX; Botulinum neurotoxin type A1Clostridium botulinum
Botulinum neurotoxin type BBoNT/B; Bontoxilysin-BClostridium botulinum
Elongation factor 2EF-2Homo sapiens (human)
Lethal factorLF; EC 3.4.24.83; Anthrax lethal toxin endopeptidase componentBacillus anthracis
Calmodulin-sensitive adenylate cyclaseEC 4.6.1.1; ATP pyrophosphate-lyase; Adenylyl cyclase; Anthrax edema toxin adenylate cyclase component; Edema factor; EFBacillus anthracis
Heat-stable enterotoxin receptorSTA receptor; hSTAR; EC 4.6.1.2; Guanylyl cyclase C; GC-C; Intestinal guanylate cyclaseHomo sapiens (human)
Dual specificity mitogen-activated protein kinase kinase 7MAP kinase kinase 7; MAPKK 7; EC 2.7.12.2; JNK-activating kinase 2; MAPK/ERK kinase 7; MEK 7; Stress-activated protein kinase kinase 4; SAPK kinase 4; SAPKK-4; SAPKK4; c-Jun N-terminal kinase kinase 2; JNK kinase 2; JNKK 2Homo sapiens (human)
Calmodulin-1Homo sapiens (human)
Protective antigenPA; Anthrax toxins translocating protein; PA-83; PA83Bacillus anthracis
Dual specificity mitogen-activated protein kinase kinase 4MAP kinase kinase 4; MAPKK 4; EC 2.7.12.2; JNK-activating kinase 1; MAPK/ERK kinase 4; MEK 4; SAPK/ERK kinase 1; SEK1; Stress-activated protein kinase kinase 1; SAPK kinase 1; SAPKK-1; SAPKK1; c-Jun N-terminal kinase kinase 1; JNKKHomo sapiens (human)
Thioredoxin reductase 1, cytoplasmicTR; EC 1.8.1.9; Gene associated with retinoic and interferon-induced mortality 12 protein; GRIM-12; Gene associated with retinoic and IFN-induced mortality 12 protein; KM-102-derived reductase-like factor; Thioredoxin reductase TR1Homo sapiens (human)
Tetanus toxinEC 3.4.24.68; TentoxylysinClostridium tetani E88
Heat-stable enterotoxin ST-IA/ST-PSTh; STpEscherichia coli
Proheparin-binding EGF-like growth factorHomo sapiens (human)
Botulinum neurotoxin type EBoNT/E; Bontoxilysin-EClostridium botulinum
CD9 antigen5H9 antigen; Cell growth-inhibiting gene 2 protein; Leukocyte antigen MIC3; Motility-related protein; MRP-1; Tetraspanin-29; Tspan-29; p24Homo sapiens (human)
Synaptosomal-associated protein 25SNAP-25; Super protein; SUP; Synaptosomal-associated 25 kDa proteinHomo sapiens (human)
Diphtheria toxinDT; NAD(+)--diphthamide ADP-ribosyltransferase; 2.4.2.36Corynephage beta
Synaptotagmin-1Synaptotagmin I; SytI; p65Homo sapiens (human)
Vesicle-associated membrane protein 1VAMP-1; Synaptobrevin-1Homo sapiens (human)
Vesicle-associated membrane protein 2VAMP-2; Synaptobrevin-2Homo sapiens (human)
Na(+)/H(+) exchange regulatory cofactor NHE-RF4NHERF-4; Intestinal and kidney-enriched PDZ protein; Natrium-phosphate cotransporter IIa C-terminal-associated protein 2; Na/Pi cotransporter C-terminal-associated protein 2; NaPi-Cap2; PDZ domain-containing protein 2; PDZ domain-containing protein 3; SodHomo sapiens (human)
Programmed cell death 6-interacting proteinPDCD6-interacting protein; ALG-2-interacting protein 1; ALG-2-interacting protein X; Hp95Homo sapiens (human)
Ha70 proteinClostridium botulinum
HA-17 Clostridium botulinum
HA-33 protein Clostridium botulinum
NTNHA Clostridium botulinum
Botulinum neurotoxin type FBoNT/F; Bontoxilysin-FClostridium botulinum
Botulinum neurotoxin type CBoNT/C; Bontoxilysin-C1; BoNT/C1; Botulinum neurotoxin type C1Clostridium phage c-st
Botulinum neurotoxin type DBoNT/D; Bontoxilysin-DClostridium botulinum D phage
Botulinum neurotoxin type GBoNT/G; Bontoxilysin-GClostridium botulinum

Compounds (7)

CompoundDescription
hydronium ion
CalciumA basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
niacinamideAn important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake.
nadA coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed)
adenosine triphosphateAn adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter.
cyclic ampAn adenine nucleotide containing one phosphate group which is esterified to both the 3'- and 5'-positions of the sugar moiety. It is a second messenger and a key intracellular regulator, functioning as a mediator of activity for a number of hormones, including epinephrine, glucagon, and ACTH.