| Protein | Synonyms | Taxonomy |
|---|
| Kynurenine 3-monooxygenase | EC 1.14.13.9; Biosynthesis of nicotinic acid protein 4; Kynurenine 3-hydroxylase | Saccharomyces cerevisiae S288C |
| 3-hydroxyanthranilate 3,4-dioxygenase | EC 1.13.11.6; 3-hydroxyanthranilate oxygenase; 3-HAO; 3-hydroxyanthranilic acid dioxygenase; HAD; Biosynthesis of nicotinic acid protein 1 | Saccharomyces cerevisiae S288C |
| Nicotinamidase | EC 3.5.1.19; Nicotinamide deamidase; NAMase | Saccharomyces cerevisiae S288C |
| Nicotinate phosphoribosyltransferase | NAPRTase; EC 6.3.4.21 | Saccharomyces cerevisiae S288C |
| Nicotinamide riboside kinase | NRK; NmR-K; EC 2.7.1.22; Nicotinic acid riboside kinase; 2.7.1.173; Ribosylnicotinamide kinase; RNK; Ribosylnicotinic acid kinase | Saccharomyces cerevisiae S288C |
| Kynurenine formamidase | KFA; KFase; EC 3.5.1.9; Arylformamidase; Biosynthesis of nicotinic acid protein 7; N-formylkynurenine formamidase; FKF | Saccharomyces cerevisiae S288C |
| Uridine nucleosidase | EC 3.2.2.3; Uridine ribohydrolase | Saccharomyces cerevisiae S288C |
| NAD-dependent histone deacetylase SIR2 | EC 2.3.1.286; Regulatory protein SIR2; Silent information regulator 2 | Saccharomyces cerevisiae S288C |
| Indoleamine 2,3-dioxygenase | IDO; EC 1.13.11.52; Biosynthesis of nicotinic acid protein 2 | Saccharomyces cerevisiae S288C |
| Kynureninase | EC 3.7.1.3; Biosynthesis of nicotinic acid protein 5; L-kynurenine hydrolase | Saccharomyces cerevisiae S288C |
| Glutamine-dependent NAD(+) synthetase | EC 6.3.5.1; NAD(+) synthase [glutamine-hydrolyzing] | Saccharomyces cerevisiae S288C |
| Nicotinate-nucleotide pyrophosphorylase [carboxylating] | EC 2.4.2.19; Quinolinate phosphoribosyltransferase [decarboxylating]; QAPRTase | Saccharomyces cerevisiae S288C |
| Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 | NMN/NaMN adenylyltransferase 2; EC 2.7.7.1; EC 2.7.7.18; NAD(+) diphosphorylase 2; NAD(+) pyrophosphorylase 2; Nicotinamide-nucleotide adenylyltransferase 2; NMN adenylyltransferase 2; NMNAT 2; Nicotinate-nucleotide adenylyltransferase 2; NaMN adenylyltra | Saccharomyces cerevisiae S288C |
| Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 | NMN/NaMN adenylyltransferase 1; EC 2.7.7.1; EC 2.7.7.18; NAD(+) diphosphorylase 1; NAD(+) pyrophosphorylase 1; Nicotinamide-nucleotide adenylyltransferase 1; NMN adenylyltransferase 1; NMNAT 1; Nicotinate-nucleotide adenylyltransferase 1; NaMN adenylyltra | Saccharomyces cerevisiae S288C |
| Compound | Description |
|---|
| hydronium ion | |
| Orthophosphate | |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| glutamic acid | A non-essential amino acid naturally occurring in the L-form. Glutamic acid is the most common excitatory neurotransmitter in the CENTRAL NERVOUS SYSTEM. |
| Adenosine Triphosphate | An adenine nucleotide containing three phosphate groups esterified to the sugar moiety. In addition to its crucial roles in metabolism adenosine triphosphate is a neurotransmitter. |
| glutamine | A non-essential amino acid present abundantly throughout the body and is involved in many metabolic processes. It is synthesized from GLUTAMIC ACID and AMMONIA. It is the principal carrier of NITROGEN in the body and is an important energy source for many cells. |
| adenosine diphosphate | Adenosine 5'-(trihydrogen diphosphate). An adenine nucleotide containing two phosphate groups esterified to the sugar moiety at the 5'-position. |
| adenosine monophosphate | Adenine nucleotide containing one phosphate group esterified to the sugar moiety in the 2'-, 3'-, or 5'-position. |
| tryptophan | An essential amino acid that is necessary for normal growth in infants and for NITROGEN balance in adults. It is a precursor of INDOLE ALKALOIDS in plants. It is a precursor of SEROTONIN (hence its use as an antidepressant and sleep aid). It can be a precursor to NIACIN, albeit inefficiently, in mammals. |
| phosphoribosyl pyrophosphate | The key substance in the biosynthesis of histidine, tryptophan, and purine and pyrimidine nucleotides. |
| niacinamide | An important compound functioning as a component of the coenzyme NAD. Its primary significance is in the prevention and/or cure of blacktongue and PELLAGRA. Most animals cannot manufacture this compound in amounts sufficient to prevent nutritional deficiency and it therefore must be supplemented through dietary intake. |
| niacin | A water-soluble vitamin of the B complex occurring in various animal and plant tissues. It is required by the body for the formation of coenzymes NAD and NADP. It has PELLAGRA-curative, vasodilating, and antilipemic properties. |
| Water | A clear, odorless, tasteless liquid that is essential for most animal and plant life and is an excellent solvent for many substances. The chemical formula is hydrogen oxide (H2O). (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| quinolinic acid | A metabolite of tryptophan with a possible role in neurodegenerative disorders. Elevated CSF levels of quinolinic acid are correlated with the severity of neuropsychological deficits in patients who have AIDS. |
| nicotinamide mononucleotide | 3-Carbamoyl-1-beta-D-ribofuranosyl pyridinium hydroxide-5'phosphate, inner salt. A nucleotide in which the nitrogenous base, nicotinamide, is in beta-N-glycosidic linkage with the C-1 position of D-ribose. Synonyms: Nicotinamide Ribonucleotide; NMN. |
| kynurenine | A metabolite of the essential amino acid tryptophan metabolized via the tryptophan-kynurenine pathway. |
| nicotinamide-beta-riboside | |
| NAD | A coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is found widely in nature and is involved in numerous enzymatic reactions in which it serves as an electron carrier by being alternately oxidized (NAD+) and reduced (NADH). (Dorland, 27th ed) |
| alanine | A non-essential amino acid that occurs in high levels in its free state in plasma. It is produced from pyruvate by transamination. It is involved in sugar and acid metabolism, increases IMMUNITY, and provides energy for muscle tissue, BRAIN, and the CENTRAL NERVOUS SYSTEM. |
| 3-hydroxyanthranilic acid | An oxidation product of tryptophan metabolism. It may be a free radical scavenger and a carcinogen. |
| N'-formylkynurenine | a photochemical breakdown product of tryptophan in proteins; RN given refers to parent cpd without isomeric designation |
| nicotinic acid adenine dinucleotide | intermediate in the biosynthesis of NAD |
| creolin | from refined coal tar oils |
| pyrophosphate | |