Page last updated: 2024-10-06
DNA Damage Reversal
Proteins (8)
| Protein | Synonyms | Taxonomy |
|---|
| DNA oxidative demethylase ALKBH2 | EC 1.14.11.33; Alkylated DNA repair protein alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; Oxy DC1 | Homo sapiens (human) |
| RNA demethylase ALKBH5 | EC 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5 | Homo sapiens (human) |
| Methylated-DNA--protein-cysteine methyltransferase | EC 2.1.1.63; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferase | Homo sapiens (human) |
| Alpha-ketoglutarate-dependent dioxygenase FTO | Fat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; 1.14.11.-; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; 1.14.11.-; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethyl | Homo sapiens (human) |
| Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 | EC 1.14.11.54; Alkylated DNA repair protein alkB homolog 3; hABH3; DEPC-1; Prostate cancer antigen 1 | Homo sapiens (human) |
| Activating signal cointegrator 1 complex subunit 3 | EC 3.6.4.12; ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200 | Homo sapiens (human) |
| Activating signal cointegrator 1 complex subunit 1 | ASC-1 complex subunit p50; Trip4 complex subunit p50 | Homo sapiens (human) |
| Activating signal cointegrator 1 complex subunit 2 | ASC-1 complex subunit p100; Trip4 complex subunit p100 | Homo sapiens (human) |
Compounds (10)
| Compound | Description |
|---|
| Succinate | |
| iron | A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. |
| Carbon Dioxide | A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals. |
| Zinc | A metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn. |
| adenosine | A nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter. |
| formaldehyde | A highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717) |
| Oxygen | An element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration. |
| n-methyladenosine | is a inhibitor of cell differentiation |
| alpha-Ketoglutarate | |
| acetaldehyde | A colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis. |