Page last updated: 2024-10-06

DNA Damage Reversal

Proteins (8)

ProteinSynonymsTaxonomy
DNA oxidative demethylase ALKBH2EC 1.14.11.33; Alkylated DNA repair protein alkB homolog 2; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2; Oxy DC1Homo sapiens (human)
RNA demethylase ALKBH5EC 1.14.11.53; Alkylated DNA repair protein alkB homolog 5; Alpha-ketoglutarate-dependent dioxygenase alkB homolog 5Homo sapiens (human)
Methylated-DNA--protein-cysteine methyltransferaseEC 2.1.1.63; 6-O-methylguanine-DNA methyltransferase; MGMT; O-6-methylguanine-DNA-alkyltransferaseHomo sapiens (human)
Alpha-ketoglutarate-dependent dioxygenase FTOFat mass and obesity-associated protein; U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; 1.14.11.-; U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO; 1.14.11.-; mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO; m6A(m)-demethylHomo sapiens (human)
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 3EC 1.14.11.54; Alkylated DNA repair protein alkB homolog 3; hABH3; DEPC-1; Prostate cancer antigen 1Homo sapiens (human)
Activating signal cointegrator 1 complex subunit 3EC 3.6.4.12; ASC-1 complex subunit p200; ASC1p200; Helicase, ATP binding 1; Trip4 complex subunit p200Homo sapiens (human)
Activating signal cointegrator 1 complex subunit 1ASC-1 complex subunit p50; Trip4 complex subunit p50Homo sapiens (human)
Activating signal cointegrator 1 complex subunit 2ASC-1 complex subunit p100; Trip4 complex subunit p100Homo sapiens (human)

Compounds (10)

CompoundDescription
Succinate
ironA metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
Carbon DioxideA colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.
ZincA metallic element of atomic number 30 and atomic weight 65.38. It is a necessary trace element in the diet, forming an essential part of many enzymes, and playing an important role in protein synthesis and in cell division. Zinc deficiency is associated with ANEMIA, short stature, HYPOGONADISM, impaired WOUND HEALING, and geophagia. It is known by the symbol Zn.
adenosineA nucleoside that is composed of ADENINE and D-RIBOSE. Adenosine or adenosine derivatives play many important biological roles in addition to being components of DNA and RNA. Adenosine itself is a neurotransmitter.
formaldehydeA highly reactive aldehyde gas formed by oxidation or incomplete combustion of hydrocarbons. In solution, it has a wide range of uses: in the manufacture of resins and textiles, as a disinfectant, and as a laboratory fixative or preservative. Formaldehyde solution (formalin) is considered a hazardous compound, and its vapor toxic. (From Reynolds, Martindale The Extra Pharmacopoeia, 30th ed, p717)
OxygenAn element with atomic symbol O, atomic number 8, and atomic weight [15.99903; 15.99977]. It is the most abundant element on earth and essential for respiration.
n-methyladenosineis a inhibitor of cell differentiation
alpha-Ketoglutarate
acetaldehydeA colorless, flammable liquid used in the manufacture of acetic acid, perfumes, and flavors. It is also an intermediate in the metabolism of alcohol. It has a general narcotic action and also causes irritation of mucous membranes. Large doses may cause death from respiratory paralysis.