Page last updated: 2024-09-05

vx-745 and vk 19911

vx-745 has been researched along with vk 19911 in 2 studies

Compound Research Comparison

Studies (vx-745)	Trials (vx-745)	Recent Studies (post-2010) (vx-745)	Studies (vk 19911)	Trials (vk 19911)	Recent Studies (post-2010) (vk 19911)
58	1	35	5	0	1

Protein Interaction Comparison

Protein	Taxonomy	vk 19911 (IC50)
Mitogen-activated protein kinase 13	Homo sapiens (human)	0.1216
Amine oxidase [flavin-containing] B	Rattus norvegicus (Norway rat)	0.038
Mitogen-activated protein kinase 12	Homo sapiens (human)	0.1216
Mitogen-activated protein kinase 11	Homo sapiens (human)	0.1216
Mitogen-activated protein kinase 14	Homo sapiens (human)	0.1009

Research

Studies (2)

Timeframe	Studies, this research(%)	All Research%
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (50.00)	29.6817
2010's	1 (50.00)	24.3611
2020's	0 (0.00)	2.80

Authors

Authors	Studies
Aaes, H; Binderup, L; Björkling, F; Fjording, MS; Ottosen, ER; Skak-Nielsen, T; Sørensen, MD	1
Bellon, SF; Bemis, GW; Chen, G; Cochran, JE; Duffy, JP; Evindar, G; Ford, PJ; Galullo, VP; Gao, H; Germann, UA; Green, J; Harrington, EM; Huang, C; Jones, P; Murcko, MA; Pazhanisamy, S; Salituro, FG; Su, MS; Taslimi, P; Wang, YM; Wilson, KP	1

Other Studies

2 other study(ies) available for vx-745 and vk 19911

Article	Year
Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity. Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26 Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Dermatitis, Contact; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-2; Leukocytes, Mononuclear; Ligands; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Peroxidase; Structure-Activity Relationship; Tumor Necrosis Factor-alpha	2003
The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor. ACS medicinal chemistry letters, 2011, Oct-13, Volume: 2, Issue:10 Topics:	2011

Article

Year

Synthesis and structure-activity relationship of aminobenzophenones. A novel class of p38 MAP kinase inhibitors with high antiinflammatory activity.

Journal of medicinal chemistry, 2003, Dec-18, Volume: 46, Issue:26

Topics: Aniline Compounds; Animals; Anti-Inflammatory Agents, Non-Steroidal; Benzophenones; Dermatitis, Contact; Female; Humans; In Vitro Techniques; Interleukin-1; Interleukin-2; Leukocytes, Mononuclear; Ligands; Mice; Mice, Inbred Strains; Mitogen-Activated Protein Kinases; Models, Molecular; p38 Mitogen-Activated Protein Kinases; Peroxidase; Structure-Activity Relationship; Tumor Necrosis Factor-alpha

2003

The Discovery of VX-745: A Novel and Selective p38α Kinase Inhibitor.

ACS medicinal chemistry letters, 2011, Oct-13, Volume: 2, Issue:10

Topics:

2011