Compounds > mk 436
Page last updated: 2024-09-03

mk 436 and suramin

mk 436 has been researched along with suramin in 4 studies

Compound Research Comparison

Studies
(mk 436)		Trials
(mk 436)		Recent Studies (post-2010)
(mk 436)		Studies
(suramin)		Trials
(suramin)		Recent Studies (post-2010) (suramin)
20003,02392431

Protein Interaction Comparison

ProteinTaxonomymk 436 (IC50)suramin (IC50)
ATP-dependent 6-phosphofructokinaseTrypanosoma brucei brucei3
Tyrosine-protein phosphatase non-receptor type 1Homo sapiens (human)9.76
P2X purinoceptor 2Rattus norvegicus (Norway rat)4
DNA-dependent protein kinase catalytic subunitHomo sapiens (human)1.7
DNA primaseMycobacterium tuberculosis CDC15518.2
RmtAAspergillus nidulans5.9
Reverse transcriptase/RNaseH Human immunodeficiency virus 19.4
NAD-dependent protein deacetylase sirtuin-2Homo sapiens (human)1.15
NAD-dependent protein deacetylase sirtuin-1Homo sapiens (human)1.5667
Protein arginine N-methyltransferase 1Homo sapiens (human)5.33
NAD-dependent protein deacylase sirtuin-5, mitochondrialHomo sapiens (human)2.5

Research

Studies (4)

TimeframeStudies, this research(%)All Research%
pre-19902 (50.00)18.7374
1990's2 (50.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Jennings, FW2
Jennings, FW; Miller, BM; Murray, PK; Urquhart, GM2

Other Studies

4 other study(ies) available for mk 436 and suramin

ArticleYear
Chemotherapy of CNS-trypanosomiasis: combination chemotherapy with a 5-nitroimidazole (MK 436), an arsenical (Cymelarsan) and suramin.
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1991, Volume: 42, Issue:3

    Topics: Animals; Arsenicals; Brain Diseases; Disease Models, Animal; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1991
Chemotherapy of CNS-trypanosomiasis: the combined use of the arsenicals and nitro-compounds.
    Tropical medicine and parasitology : official organ of Deutsche Tropenmedizinische Gesellschaft and of Deutsche Gesellschaft fur Technische Zusammenarbeit (GTZ), 1991, Volume: 42, Issue:2

    Topics: Animals; Antiprotozoal Agents; Arsenicals; Brain Diseases; Drug Synergism; Drug Therapy, Combination; Female; Ketoconazole; Metronidazole; Mice; Nifurtimox; Nitro Compounds; Nitroimidazoles; Oxidation-Reduction; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1991
The use of 2-substituted 5-nitroimidazoles in the treatment of chronic murine Trypanosoma brucei infections with central nervous system involvement.
    Zeitschrift fur Parasitenkunde (Berlin, Germany), 1984, Volume: 70, Issue:6

    Topics: Animals; Antiprotozoal Agents; Brain; Chronic Disease; Drug Therapy, Combination; Female; Mice; Mice, Inbred Strains; Nitroimidazoles; Rodent Diseases; Suramin; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African

1984
Treatment with suramin and 2-substituted 5-nitroimidazoles of chronic murine Trypanosoma brucei infections with central nervous system involvement.
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1983, Volume: 77, Issue:5

    Topics: Animals; Antiprotozoal Agents; Cattle; Central Nervous System Diseases; Drug Therapy, Combination; Female; Mice; Nitroimidazoles; Suramin; Trypanosoma brucei brucei; Trypanosomiasis, African

1983