Page last updated: 2024-09-02

exp3174 and l 158809

exp3174 has been researched along with l 158809 in 10 studies

Compound Research Comparison

Studies
(exp3174)
Trials
(exp3174)
Recent Studies (post-2010)
(exp3174)
Studies
(l 158809)
Trials
(l 158809)
Recent Studies (post-2010) (l 158809)
236294313707

Protein Interaction Comparison

ProteinTaxonomyexp3174 (IC50)l 158809 (IC50)
Type-1A angiotensin II receptor Rattus norvegicus (Norway rat)0.0021
Type-1B angiotensin II receptorRattus norvegicus (Norway rat)0.0012
Type-1 angiotensin II receptorHomo sapiens (human)0.0015
Type-1 angiotensin II receptorOryctolagus cuniculus (rabbit)0.0003
Type-2 angiotensin II receptorRattus norvegicus (Norway rat)0.0021
Type-2 angiotensin II receptorHomo sapiens (human)0.0002
5-hydroxytryptamine receptor 1AMus musculus (house mouse)0.0021

Research

Studies (10)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's8 (80.00)18.2507
2000's1 (10.00)29.6817
2010's1 (10.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Chakravarty, PK; Chang, RS; Chen, A; Chen, TB; Faust, KA; Gable, RA; Kivlighn, SD; Lotti, VJ; Naylor, EM; Zingaro, GJ1
Beier, N; Bokel, HH; Dorsch, D; Lues, I; Mederski, WW; Schelling, P1
Altenbach, RJ; Basha, FZ; Boyd, SA; Brune, ME; Buckner, SA; Crowell, D; De, B; Drizin, I; Winn, M; Zydowsky, TM1
Ashton, WT; Cantone, CL; Chang, LL; Chang, RS; Chen, TB; Faust, KA; Hutchins, SM; Lotti, VJ; MacCoss, M; Strelitz, RA1
Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR1
Berellini, G; Cruciani, G; Mannhold, R1
Giridhar, R; Murumkar, P; Naik, P; Yadav, MR1
Chakravarty, PK; Chang, RS; Clineschmidt, BV; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Patchett, AA; Siegl, PK1
Chakravarty, PK; Chang, RS; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Patchett, AA; Siegl, PK; Sweet, CS1
Bauer, JH; Reams, GP1

Reviews

3 review(s) available for exp3174 and l 158809

ArticleYear
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
    Journal of medicinal chemistry, 1996, Feb-02, Volume: 39, Issue:3

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship

1996
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
    Bioorganic & medicinal chemistry, 2010, Dec-15, Volume: 18, Issue:24

    Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan

2010
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs.
    Archives of internal medicine, 1995, Jul-10, Volume: 155, Issue:13

    Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan

1995

Other Studies

7 other study(ies) available for exp3174 and l 158809

ArticleYear
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.
    Journal of medicinal chemistry, 1994, Nov-25, Volume: 37, Issue:24

    Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dogs; Imidazoles; Macaca mulatta; Pyridines; Rats

1994
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.
    Journal of medicinal chemistry, 1994, May-27, Volume: 37, Issue:11

    Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; Losartan; Male; Molecular Structure; Pyridines; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Angiotensin; Structure-Activity Relationship; Tetrazoles

1994
2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists.
    Journal of medicinal chemistry, 1993, Sep-03, Volume: 36, Issue:18

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Biological Availability; Iodine Radioisotopes; Liver; Male; Muscle Contraction; Niacin; Nicotinic Acids; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles

1993
Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.
    Journal of medicinal chemistry, 1993, Mar-05, Volume: 36, Issue:5

    Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding, Competitive; Blood Pressure; Male; Molecular Structure; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Structure-Activity Relationship; Triazoles

1993
Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists.
    Journal of medicinal chemistry, 2005, Jun-30, Volume: 48, Issue:13

    Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Binding Sites; Biphenyl Compounds; Kinetics; Losartan; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Pharmaceutical Preparations; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Structure-Activity Relationship; Tetrazoles

2005
In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1

    Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Brain; Cell Membrane; Culture Techniques; Humans; Imidazoles; Losartan; Macaca mulatta; Muscle, Smooth, Vascular; Rabbits; Rats; Species Specificity; Tetrazoles

1992
In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
    The Journal of pharmacology and experimental therapeutics, 1992, Volume: 262, Issue:1

    Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Pressoreceptors; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles

1992