exp3174 and l 158809
exp3174 has been researched along with l 158809 in 10 studies
Compound Research Comparison
| Studies (exp3174) | Trials (exp3174) | Recent Studies (post-2010) (exp3174) | Studies (l 158809) | Trials (l 158809) | Recent Studies (post-2010) (l 158809) |
|---|---|---|---|---|---|
| 236 | 29 | 43 | 137 | 0 | 7 |
Protein Interaction Comparison
| Protein | Taxonomy | exp3174 (IC50) | l 158809 (IC50) |
|---|---|---|---|
| Type-1A angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0021 | |
| Type-1B angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0012 | |
| Type-1 angiotensin II receptor | Homo sapiens (human) | 0.0015 | |
| Type-1 angiotensin II receptor | Oryctolagus cuniculus (rabbit) | 0.0003 | |
| Type-2 angiotensin II receptor | Rattus norvegicus (Norway rat) | 0.0021 | |
| Type-2 angiotensin II receptor | Homo sapiens (human) | 0.0002 | |
| 5-hydroxytryptamine receptor 1A | Mus musculus (house mouse) | 0.0021 |
Research
Studies (10)
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 8 (80.00) | 18.2507 |
| 2000's | 1 (10.00) | 29.6817 |
| 2010's | 1 (10.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Authors
| Authors | Studies |
|---|---|
| Chakravarty, PK; Chang, RS; Chen, A; Chen, TB; Faust, KA; Gable, RA; Kivlighn, SD; Lotti, VJ; Naylor, EM; Zingaro, GJ | 1 |
| Beier, N; Bokel, HH; Dorsch, D; Lues, I; Mederski, WW; Schelling, P | 1 |
| Altenbach, RJ; Basha, FZ; Boyd, SA; Brune, ME; Buckner, SA; Crowell, D; De, B; Drizin, I; Winn, M; Zydowsky, TM | 1 |
| Ashton, WT; Cantone, CL; Chang, LL; Chang, RS; Chen, TB; Faust, KA; Hutchins, SM; Lotti, VJ; MacCoss, M; Strelitz, RA | 1 |
| Goldberg, MR; Greenlee, WJ; Irvin, JD; Prendergast, K; Smith, RD; Timmermans, PB; Wexler, RR | 1 |
| Berellini, G; Cruciani, G; Mannhold, R | 1 |
| Giridhar, R; Murumkar, P; Naik, P; Yadav, MR | 1 |
| Chakravarty, PK; Chang, RS; Clineschmidt, BV; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Patchett, AA; Siegl, PK | 1 |
| Chakravarty, PK; Chang, RS; Greenlee, WJ; Lotti, VJ; Mantlo, NB; Ondeyka, DL; Patchett, AA; Siegl, PK; Sweet, CS | 1 |
| Bauer, JH; Reams, GP | 1 |
Reviews
3 review(s) available for exp3174 and l 158809
| Article | Year |
|---|---|
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Humans; Receptors, Angiotensin; Structure-Activity Relationship | 1996 |
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.
Topics: Angiotensin II Type 1 Receptor Blockers; Angiotensin Receptor Antagonists; Antihypertensive Agents; Humans; Losartan | 2010 |
The angiotensin II type 1 receptor antagonists. A new class of antihypertensive drugs.
Topics: Acrylates; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Benzimidazoles; Benzoates; Biphenyl Compounds; Humans; Imidazoles; Irbesartan; Losartan; Pyridines; Quinolines; Telmisartan; Tetrazoles; Thiophenes; Valine; Valsartan | 1995 |
Other Studies
7 other study(ies) available for exp3174 and l 158809
| Article | Year |
|---|---|
A highly potent, orally active imidazo[4,5-b]pyridine biphenylacylsulfonamide (MK-996; L-159,282): a new AT1-selective angiotensin II receptor antagonist.
Topics: Administration, Oral; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Dogs; Imidazoles; Macaca mulatta; Pyridines; Rats | 1994 |
Non-peptide angiotensin II receptor antagonists: synthesis and biological activity of a series of novel 4,5-dihydro-4-oxo-3H-imidazo[4,5-c]pyridine derivatives.
Topics: Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Imidazoles; Losartan; Male; Molecular Structure; Pyridines; Rabbits; Rats; Rats, Inbred SHR; Rats, Wistar; Receptors, Angiotensin; Structure-Activity Relationship; Tetrazoles | 1994 |
2-(Alkylamino)nicotinic acid and analogs. Potent angiotensin II antagonists.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Aorta; Biological Availability; Iodine Radioisotopes; Liver; Male; Muscle Contraction; Niacin; Nicotinic Acids; Rabbits; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Angiotensin; Tetrazoles | 1993 |
Nonpeptide angiotensin II antagonists derived from 4H-1,2,4-triazoles and 3H-imidazo[1,2-b][1,2,4]triazoles.
Topics: Angiotensin II; Angiotensin Receptor Antagonists; Animals; Aorta; Binding, Competitive; Blood Pressure; Male; Molecular Structure; Rabbits; Rats; Rats, Sprague-Dawley; Receptors, Angiotensin; Structure-Activity Relationship; Triazoles | 1993 |
Pharmacophore, drug metabolism, and pharmacokinetics models on non-peptide AT1, AT2, and AT1/AT2 angiotensin II receptor antagonists.
Topics: Angiotensin II Type 1 Receptor Blockers; Benzimidazoles; Binding Sites; Biphenyl Compounds; Kinetics; Losartan; Models, Molecular; Molecular Conformation; Oxidation-Reduction; Pharmaceutical Preparations; Receptor, Angiotensin, Type 1; Receptor, Angiotensin, Type 2; Structure-Activity Relationship; Tetrazoles | 2005 |
In vitro pharmacology of L-158,809, a new highly potent and selective angiotensin II receptor antagonist.
Topics: Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Binding, Competitive; Biphenyl Compounds; Brain; Cell Membrane; Culture Techniques; Humans; Imidazoles; Losartan; Macaca mulatta; Muscle, Smooth, Vascular; Rabbits; Rats; Species Specificity; Tetrazoles | 1992 |
In vivo pharmacology of L-158,809, a new highly potent and selective nonpeptide angiotensin II receptor antagonist.
Topics: Administration, Oral; Aldosterone; Angiotensin II; Angiotensin Receptor Antagonists; Animals; Antihypertensive Agents; Biphenyl Compounds; Blood Pressure; Female; Imidazoles; Injections, Intravenous; Losartan; Macaca mulatta; Male; Pressoreceptors; Pyridines; Rats; Rats, Inbred Strains; Tetrazoles | 1992 |