Page last updated: 2024-09-05

atropine and y 27632

atropine has been researched along with y 27632 in 8 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(y 27632)
Trials
(y 27632)
Recent Studies (post-2010) (y 27632)
26,7111,2591,6971,9243891

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)y 27632 (IC50)
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)6
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)6
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)6
Chain I, cAMP-dependent protein kinase inhibitor alphasynthetic construct6
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)6
Chain A, cAMP-dependent protein kinase, alpha-catalytic subunitBos taurus (cattle)6
Chain I, cAMP-dependent protein kinase inhibitor alphasynthetic construct6
Rho-associated protein kinase 2Homo sapiens (human)0.1942
Ribosomal protein S6 kinase alpha-5Homo sapiens (human)8.3
cAMP-dependent protein kinase catalytic subunit alphaBos taurus (cattle)6.1
C-C motif chemokine 2Homo sapiens (human)2.6303
Rho-associated protein kinase 1Homo sapiens (human)0.3713
Serine/threonine-protein kinase N2Homo sapiens (human)0.6
Rho-associated protein kinase 2Bos taurus (cattle)6.1
Rho-associated protein kinase 2Rattus norvegicus (Norway rat)0.8

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (50.00)29.6817
2010's4 (50.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Büyükafsar, K; Levent, A1
Kaufman, PL; Tian, B1
Chiba, Y; Misawa, M; Sakai, H1
Jin, L; Priviero, FB; Teixeira, CE; Webb, RC; Ying, Z1
Bao, HF; Eaton, AF; Eaton, DC; Helms, MN; Jain, L; Ramosevac, S; Self, J; Takemura, Y1
Allain, AV; Kadowitz, PJ; Lasker, GF; Murthy, SN; Pankey, EA; Stasch, JP1
Khin, PP; Sohn, UD; Zaw, TS1
Buyukafsar, K; Cevik, OS; Koyuncu, DD; Sahin, L1

Other Studies

8 other study(ies) available for atropine and y 27632

ArticleYear
Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter.
    British journal of pharmacology, 2004, Volume: 143, Issue:3

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Aorta; Atropine; Blotting, Western; Calcium Channel Blockers; Carbachol; Dose-Response Relationship, Drug; Electric Stimulation; Enzyme Inhibitors; Guanethidine; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Muscle Contraction; Muscle, Smooth; Nitric Oxide Synthase; Nitroarginine; Phenylephrine; Potassium Chloride; Protein Serine-Threonine Kinases; Pyridines; rho-Associated Kinases; Sheep; Tetrodotoxin; Ureter; Vasoconstrictor Agents; Vasodilator Agents

2004
Effects of the Rho kinase inhibitor Y-27632 and the phosphatase inhibitor calyculin A on outflow facility in monkeys.
    Experimental eye research, 2005, Volume: 80, Issue:2

    Topics: Amides; Animals; Aqueous Humor; Atropine; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Macaca fascicularis; Macaca mulatta; Male; Marine Toxins; Oxazoles; Phosphoric Monoester Hydrolases; Pyridines; Rheology; Trabecular Meshwork

2005
Endothelin-1-induced translocation of RhoA is mediated by endothelin ET(A) receptors in rat bronchial smooth muscle.
    European journal of pharmacology, 2005, Jul-11, Volume: 517, Issue:3

    Topics: Amides; Animals; Atropine; Blotting, Western; Bronchi; Cell Membrane; Cytosol; Dose-Response Relationship, Drug; Endothelin A Receptor Antagonists; Endothelin B Receptor Antagonists; Endothelin-1; In Vitro Techniques; Indomethacin; Male; Muscle Contraction; Muscle Relaxants, Central; Muscle, Smooth; Oligopeptides; Peptides, Cyclic; Piperidines; Protein Transport; Pyridines; Rats; Rats, Wistar; Receptor, Endothelin A; rhoA GTP-Binding Protein; Time Factors

2005
Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract.
    Biochemical pharmacology, 2007, Aug-15, Volume: 74, Issue:4

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Adenosine Triphosphate; Amides; Animals; Atropine; Blotting, Western; Calcium Signaling; Dose-Response Relationship, Drug; Electric Stimulation; Endothelin-1; Enzyme Inhibitors; Guanine Nucleotide Dissociation Inhibitors; In Vitro Techniques; Intracellular Signaling Peptides and Proteins; Male; Muscle Contraction; Muscle, Smooth; Nifedipine; Protein Serine-Threonine Kinases; Pyridines; Rats; Rats, Sprague-Dawley; Reverse Transcriptase Polymerase Chain Reaction; rho-Associated Kinases; rho-Specific Guanine Nucleotide Dissociation Inhibitors; rhoA GTP-Binding Protein; Urethra; Urinary Bladder

2007
Cholinergic regulation of epithelial sodium channels in rat alveolar type 2 epithelial cells.
    American journal of physiology. Lung cellular and molecular physiology, 2013, Mar-15, Volume: 304, Issue:6

    Topics: Alveolar Epithelial Cells; Amides; Animals; Atropine; Carbachol; Cells, Cultured; Enzyme Activation; Epithelial Sodium Channel Agonists; Epithelial Sodium Channels; Membrane Potentials; Mice; Mice, Inbred C57BL; Muscarinic Agonists; Muscarinic Antagonists; Nicotine; Nicotinic Agonists; Oxotremorine; Patch-Clamp Techniques; Pyridines; Rats; Rats, Sprague-Dawley; Receptor, Muscarinic M2; Receptor, Muscarinic M3; rho-Associated Kinases; rhoA GTP-Binding Protein

2013
The selective Rho-kinase inhibitor azaindole-1 has long-lasting erectile activity in the rat.
    Urology, 2013, Volume: 81, Issue:2

    Topics: 1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine; Amides; Animals; Area Under Curve; Atropine; Blood Pressure; Diamines; Enzyme Inhibitors; Guanylate Cyclase; Indazoles; Male; Muscarinic Antagonists; Nitric Oxide; Oxadiazoles; Penile Erection; Penis; Peripheral Nerve Injuries; Protein Kinase Inhibitors; Pyridines; Pyrimidines; Quinoxalines; Rats; Rats, Sprague-Dawley; Receptors, Muscarinic; rho-Associated Kinases; Signal Transduction; Time Factors

2013
Signal Transduction Underlying the Inhibitory Mechanism of Fluoxetine on Electrical Field Stimulation Response in Rat Ileal Smooth Muscle.
    Pharmacology, 2017, Volume: 99, Issue:5-6

    Topics: 4-Aminopyridine; Amides; Animals; Atropine; Azepines; Benzophenanthridines; Bicuculline; Calcimycin; Drug Interactions; Electric Stimulation; Estrenes; Fluoxetine; Glyburide; Ileum; In Vitro Techniques; Indoles; Male; Muscle Contraction; Muscle, Smooth; NG-Nitroarginine Methyl Ester; Ondansetron; Pyridines; Pyrrolidinones; Rats; Signal Transduction; Sulfonamides; Tetraethylammonium

2017
Role of rho-kinase (ROCK) in tonic but not phasic contraction in the frog stomach smooth muscle.
    Life sciences, 2018, Apr-01, Volume: 198

    Topics: Amides; Animals; Atropine; Carbachol; Gastric Mucosa; Muscle Contraction; Muscle, Smooth; Nifedipine; Organ Culture Techniques; Pirenzepine; Pyridines; Ranidae; rho-Associated Kinases

2018