Page last updated: 2024-09-05

atropine and u-50488

atropine has been researched along with u-50488 in 8 studies

Compound Research Comparison

Studies
(atropine)
Trials
(atropine)
Recent Studies (post-2010)
(atropine)
Studies
(u-50488)
Trials
(u-50488)
Recent Studies (post-2010) (u-50488)
26,7111,2591,6971,6643209

Protein Interaction Comparison

ProteinTaxonomyatropine (IC50)u-50488 (IC50)
Delta-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorMus musculus (house mouse)0.0027
Mu-type opioid receptorRattus norvegicus (Norway rat)2.15
Kappa-type opioid receptorRattus norvegicus (Norway rat)0.7171
Kappa-type opioid receptorCavia porcellus (domestic guinea pig)0.0958
Kappa-type opioid receptorHomo sapiens (human)0.0537

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's5 (62.50)18.2507
2000's1 (12.50)29.6817
2010's2 (25.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gintzler, AR; Xu, H1
Morrone, LA; Romanelli, L; Valeri, P1
Laorden, ML; Micol, JA1
Hata, F; Nishio, H; Nishiwaki, H; Saitoh, N; Takeuchi, T1
Dun, NJ; Hwang, BH; Mizoguchi, H; Nagase, H; Narita, M; Oji, DE; Tseng, LF1
Bi, H; Guo, HT; Lu, SY; Ma, H; Ma, S; Ma, XL; Pei, JM; Sun, X; Wang, YM; Zang, YM1
Baroffio, M; Brusasco, V; Crimi, E; Rehder, K1
Chang, HH; Hung, CF; Lee, GA; Li, HJ; Su, MJ1

Other Studies

8 other study(ies) available for atropine and u-50488

ArticleYear
Opioid enhancement of evoked [Met5]enkephalin release requires activation of cholinergic receptors: possible involvement of intracellular calcium.
    Proceedings of the National Academy of Sciences of the United States of America, 1992, Mar-01, Volume: 89, Issue:5

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Calcimycin; Calcium; Colforsin; Enkephalin, D-Penicillamine (2,5)-; Enkephalin, Methionine; Enkephalins; Evoked Potentials; Fentanyl; Guinea Pigs; Hexamethonium Compounds; In Vitro Techniques; Myenteric Plexus; Naloxone; Pyrrolidines; Receptors, Muscarinic; Receptors, Opioid; Sufentanil

1992
Manifestations of acute opiate withdrawal contracture in rabbit jejunum after mu-, kappa- and delta-receptor agonist exposure.
    British journal of pharmacology, 1992, Volume: 106, Issue:1

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Hexamethonium; Hexamethonium Compounds; In Vitro Techniques; Jejunum; Male; Morphine; Muscle Contraction; Naloxone; Oligopeptides; Pyrrolidines; Rabbits; Receptors, Opioid; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu; Substance-Related Disorders; Tetrodotoxin

1992
Effects of mu-, delta- and kappa-agonists on isolated right atria of the rat.
    Neuropeptides, 1994, Volume: 26, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Benzomorphans; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; Enkephalins; Female; Heart; Heart Atria; Heart Rate; In Vitro Techniques; Male; Morphine; Naloxone; Narcotic Antagonists; Propranolol; Pyrrolidines; Rats; Rats, Sprague-Dawley; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1994
Relationship between inhibitory effect of endogenous opioid via mu-receptors and muscarinic autoinhibition in acetylcholine release from myenteric plexus of guinea pig ileum.
    Japanese journal of pharmacology, 1998, Volume: 77, Issue:4

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalins; Guinea Pigs; Ileum; In Vitro Techniques; Male; Morphinans; Muscarine; Muscarinic Agonists; Muscarinic Antagonists; Muscle, Smooth; Myenteric Plexus; Naltrexone; Narcotic Antagonists; Opioid Peptides; Receptors, Muscarinic; Receptors, Opioid, delta; Receptors, Opioid, kappa; Receptors, Opioid, mu

1998
Identification of the G-protein-coupled ORL1 receptor in the mouse spinal cord by [35S]-GTPgammaS binding and immunohistochemistry.
    British journal of pharmacology, 1999, Volume: 128, Issue:6

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; Autoradiography; Baclofen; Binding, Competitive; Dose-Response Relationship, Drug; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; Enkephalin, D-Penicillamine (2,5)-; GTP-Binding Proteins; Guanosine 5'-O-(3-Thiotriphosphate); Guanosine Diphosphate; Haloperidol; Immunohistochemistry; In Vitro Techniques; Male; Membranes; Mice; Mice, Inbred ICR; Naltrexone; Narcotic Antagonists; Nociceptin; Nociceptin Receptor; Opioid Peptides; Peptide Fragments; Propranolol; Receptors, Opioid; Somatostatin; Spinal Cord; Sulfur Radioisotopes; Yohimbine

1999
Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats.
    Life sciences, 2006, Apr-18, Volume: 78, Issue:21

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Adrenergic beta-Antagonists; Animals; Anti-Inflammatory Agents, Non-Steroidal; Antihypertensive Agents; Atropine; Dynorphins; Endothelium, Vascular; Enzyme Inhibitors; In Vitro Techniques; Indomethacin; Male; Muscle Relaxation; Muscle, Smooth, Vascular; NG-Nitroarginine Methyl Ester; Nitric Oxide; Nitric Oxide Synthase Type III; Peptide Fragments; Potassium Channel Blockers; Potassium Channels; Propranolol; Pulmonary Artery; Rats; Rats, Sprague-Dawley; Receptors, Opioid, kappa

2006
Effects of κ- and μ-opioid agonists on cholinergic neurotransmission and contraction in isolated bovine trachealis.
    Respiratory physiology & neurobiology, 2013, Jan-15, Volume: 185, Issue:2

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Acetylcholine; Analgesics, Non-Narcotic; Analgesics, Opioid; Animals; Atropine; Cattle; Drug Interactions; Electric Stimulation; Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; In Vitro Techniques; Muscarinic Agonists; Muscarinic Antagonists; Muscle Contraction; Naltrexone; Narcotic Antagonists; Pilocarpine; Receptors, Opioid, kappa; Receptors, Opioid, mu; Trachea; Tritium

2013
The differential effects of a selective kappa-opioid receptor agonist, U50488, in guinea pig heart tissues.
    BioMed research international, 2015, Volume: 2015

    Topics: 3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; Animals; Atropine; GTP-Binding Proteins; Guinea Pigs; Heart Atria; Heart Ventricles; Organ Culture Techniques; Propranolol; Receptors, Opioid, kappa

2015