Page last updated: 2024-10-15

vibsanin a

Description

vibsanin A: from the leaves of Viburnum awabuki; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
ViburnumgenusA plant genus in the family CAPRIFOLIACEAE. The common name derives from its traditional use for menstrual cramps. It is a source of viburnine, valerianic acid, vibsanin, and ursolic acid. Note that true cranberry is VACCINIUM MACROCARPON.[MeSH]Viburnaceae[no description available]

Cross-References

ID SourceID
PubMed CID154708213
CHEMBL ID4649737
MeSH IDM000604136

Synonyms (6)

Synonym
vibsanin a
CHEMBL4649737
HY-N10393
CS-0526928
DTXSID601100085
2-butenoic acid, 3-methyl-, (1r,2r,3e,5s,7e,11r)-8-(hydroxymethyl)-1,5-dimethyl-5-(4-methyl-3-penten-1-yl)-12-oxabicyclo[9.1.0]dodeca-3,7-dien-2-yl ester

Research Excerpts

Overview

Vibsanin A is an 11-membered vibsane diterpenoid and is reported to induce myeloid cell differentiation via activation of protein kinase C (PKC) without tumor-promoting activity.

ExcerptReference
"Vibsanin A is an 11-membered vibsane diterpenoid and is reported to induce myeloid cell differentiation via activation of protein kinase C (PKC) without tumor-promoting activity. "( Synthesis and evaluation of biological activities of vibsanin A analogs.
Matsuki, W; Miyazaki, S; Ogura, A; Sasazawa, Y; Simizu, S; Takao, KI; Yoshida, K, 2017
)
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (14)

Assay IDTitleYearJournalArticle
AID1650591Antiproliferative activity against human HT1080 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650592Antiproliferative activity against human A549 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650601Induction of vacuole formation in human HT1080 cells at 10 uM incubated for 24 hrs2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650599Antiproliferative activity against human PC3 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650597Antiproliferative activity against human ES2 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650596Antiproliferative activity against human SK-MEL-28 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650598Antiproliferative activity against human MCF7 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650594Antiproliferative activity against human A431 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650602Effect on Akt level in human HT1080 cells assessed as Akt level at 10 uM incubated for 24 hrs by immunoblot assay (Rvb = 1 No_unit)2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650600Antiproliferative activity against human NEC8 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650593Antiproliferative activity against human PANC1 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650595Antiproliferative activity against human HT-29 cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650603Inhibition of Akt signaling pathway in human HT1080 cells assessed as fold change in phosphorylated Akt level at 10 uM incubated for 24 hrs by immunoblot assay (Rvb = 1 No_unit)2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
AID1650604Inhibition of Akt signaling pathway in human HT1080 cells assessed as fold change in phosphorylated 70S6K level at 10 uM incubated for 24 hrs by immunoblot assay (Rvb = 1 No_unit)2020Bioorganic & medicinal chemistry, 01-15, Volume: 28, Issue:2
Identification of vibsanin A analog as a novel HSP90 inhibitor.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's4 (80.00)24.3611
2020's1 (20.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]