Compounds > tops
Page last updated: 2024-12-08

tops

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth

Description

TOPS: structure [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID23679008
SCHEMBL ID5525901
MeSH IDM0064879

Synonyms (29)

Synonym
c12h18nnao3s
tops
3-(n-ethyl-3-methylanilino)propanesulfonic acid sodium salt
FT-0639652
40567-80-4
sodium 3-(n-ethyl-3-methylanilino)propanesulfonate
AKOS016004622
3-(ethyl[3-methylphenyl]amino)-1-propanesulfonic acid
n-ethyl-n-sulfopropyl-m-toluidine sodium salt
sodium n-ethyl-n-(3-sulfopropyl)-m-toluidine
n-ethyl-n-(3-sulfopropyl)-3-methylaniline sodium salt
AKOS015897332
HY-15933
SCHEMBL5525901
n-ethyl-n-(3-sulfopropyl)-3-methylaniline,sodium salt (tops)
n-ethyl-n-sulphopropyl-m-toluidine, sodium salt
n-ethyl-n-sulfopropyl-3-toluidine sodium salt
tops, sodium salt
n-ethyl-n-(3-sulfopropyl)-3-methylaniline, sodium salt
W-202667
sodium 3-(ethyl(m-tolyl)amino)propane-1-sulfonate
AC-27729
mfcd00043050
sodium 3-[ethyl(m-tolyl)amino]propane-1-sulfonate
n-ethyl-n-(3-sulfopropyl)-3-methylaniline,sodiumsalt (tops)
SY047636
4-amino-6-cyano-3(2h)-quinazolinecarboxylicacid-1,1-dimethylethylester
AC7889
sodium;3-(n-ethyl-3-methylanilino)propane-1-sulfonate

Research Excerpts

Toxicity

ExcerptReferenceRelevance
" The acute LD50 doses in rats for PCA and TES are 15."( Nitroxyl spin label contrast enhancers for magnetic resonance imaging. Studies of acute toxicity and mutagenesis.
Afzal, V; Brasch, RC; Nitecki, DE; Wolff, S, )		0.13
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (16)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (18.75)18.7374
1990's0 (0.00)18.2507
2000's1 (6.25)29.6817
2010's0 (0.00)24.3611
2020's12 (75.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials3 (17.65%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational2 (11.76%)0.25%
Other12 (70.59%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
5,5-dimethyl-1-pyrroline-1-oxide
5,5-dimethyl-1-pyrroline-1-oxide: do not confuse with DMPO (4',5'-dihydroxy-7-methoxy-4-phenyl-5,2'-oxidocoumarin). 5,5-dimethyl-1-pyrroline N-oxide : A member of the class of 1-pyrroline nitrones (1-pyrroline N-oxides) resulting from the formal N-oxidation of 5,5-dimethyl-1-pyrroline. Used as a spin trap for the study of radicals formed by enzymatic acetaldehyde oxidation.		2101-pyrroline nitronesneuroprotective agent;
spin trapping reagent
hydroxyl radical
Hydroxyl Radical: The univalent radical OH. Hydroxyl radical is a potent oxidizing agent.		210oxygen hydride;
oxygen radical;
reactive oxygen species
singlet oxygen
Singlet Oxygen: An excited state of molecular oxygen generated photochemically or chemically. Singlet oxygen reacts with a variety of biological molecules such as NUCLEIC ACIDS; PROTEINS; and LIPIDS; causing oxidative damages.		210chalcogen;
monoatomic oxygen;
nonmetal atom		macronutrient
ConditionIndicatedRelationship StrengthStudiesTrials
Cleft Palate, Isolated
[description not available]		06.1522
Aprosodia
[description not available]		04.9111
Cleft Palate
Congenital fissure of the soft and/or hard palate, due to faulty fusion.		011.1522
Back Ache
[description not available]		02.4110
Lordosis
The anterior concavity in the curvature of the lumbar and cervical spine as viewed from the side. The term usually refers to abnormally increased curvature (hollow back, saddle back, swayback). It does not include lordosis as normal mating posture in certain animals ( = POSTURE + SEX BEHAVIOR, ANIMAL).		02.4110
Spondylisthesis
[description not available]		04.2821
Back Pain
Acute or chronic pain located in the posterior regions of the THORAX; LUMBOSACRAL REGION; or the adjacent regions.		02.4110
Spinal Stenosis
Narrowing of the spinal canal.		04.2821
Hypothermia, Accidental
[description not available]		02.4110
Hypothermia
Lower than normal body temperature, especially in warm-blooded animals.		02.4110
Constriction, Pathological
[description not available]		03.9911
Constriction, Pathologic
The condition of an anatomical structure's being constricted beyond normal dimensions.		03.9911
Non-communicable Chronic Diseases
[description not available]		02.4110
Blood Pressure, High
[description not available]		02.4110
Hypertension
Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.		02.4110
Harelip
[description not available]		04.6211
Cleft Lip
Congenital defect in the upper lip where the maxillary prominence fails to merge with the merged medial nasal prominences. It is thought to be caused by faulty migration of the mesoderm in the head region.		04.6211
Overweight
A status with BODY WEIGHT that is above certain standards. In the scale of BODY MASS INDEX, overweight is defined as having a BMI of 25.0-29.9 kg/m2. Overweight may or may not be due to increases in body fat (ADIPOSE TISSUE), hence overweight does not equal over fat.		02.4110
Femoral Fractures
Fractures of the femur.		02.4110
Fractures, Periprosthetic
[description not available]		02.4110
Health Care Associated Infection
[description not available]		01.9410
Reproductive Sterility
[description not available]		01.9410
Cross Infection
Any infection which a patient contracts in a health-care institution.		01.9410
Infertility
A reduced or absent capacity to reproduce.		01.9410
Heart Disease, Ischemic
[description not available]		0210
Myocardial Ischemia
A disorder of cardiac function caused by insufficient blood flow to the muscle tissue of the heart. The decreased blood flow may be due to narrowing of the coronary arteries (CORONARY ARTERY DISEASE), to obstruction by a thrombus (CORONARY THROMBOSIS), or less commonly, to diffuse narrowing of arterioles and other small vessels within the heart. Severe interruption of the blood supply to the myocardial tissue may result in necrosis of cardiac muscle (MYOCARDIAL INFARCTION).		0210